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Associations of Adverse Clinical Course and Ingested Substances among Patients with Deliberate Drug Poisoning: A Cohort Study from an Intensive Care Unit in Japan

Objectives Some patients with deliberate drug poisoning subsequently have an adverse clinical course. The present study aimed to examine whether the type of drugs ingested and psychiatric diagnoses were related to an adverse clinical course. Methods We conducted a cohort study of patients with deliberate drug poisoning admitted to the intensive care unit of a university hospital...

First case of Propionibacterium acnes urinary tract infection in a dog

results, and drafted the manuscript. TS performed the antimicrobial susceptibility. TT (Tsuka Takeshi) and TI carried out diagnostic imaging. TT (Takashi Takeuchi) performed the clinical work-up and care

Successful staged repair for a rare type of truncus arteriosus with interruption of the aortic arch and abnormal origin of the left coronary artery

We report a successful staged repair for a quite rare combination of truncus arteriosus (TA), Van Praagh type A4, and abnormal origin of the left coronary artery (CA). Furthermore, the case was complicated by a variant of the chromosomal anomaly in cat-cry syndrome. The presence of interruption of the aortic arch (IAA) and abnormal CA origin has been previously reported to...

Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression

Dienogest is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. In this study, we examined the direct effects of dienogest on the proliferation of human endometrial epithelial cells using an immortalized cell line. 5-Bromo-2'-deoxyuridine incorporation into the cells was inhibited by dienogest and by...

Conversion of subā€megasized DNA to desired structures using a novel Bacillus subtilis genome vector

A novel genome vector using the 4215 kb Bacillus subtilis genome provides for precise target cloning and processing of the cloned DNA to the desired structure. Each process highly dependent on homologous recombination in the host B.subtilis is distinguished from the other cloning systems. A 120 kb mouse jumonji (jmj) genomic gene was processed in the genome vector to give a...

Variations in ORAI1 Gene Associated with Kawasaki Disease

, Takashi Takeuchi, Hiromichi Hamada, Takafumi Honda, Kumi Yasukawa, Masaru Terai, Ryota Ebata, Kouji Higashi, Tsutomu Saji, Yasushi Kemmotsu, Shinichi Takatsuki, Kazunobu Ouchi, Jun Abe, Mitsuru Seki, Tohru

Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway

Masatoshi Kitagawa Takashi Takeuchi () SUMMARY In general, cell proliferation and differentiation show an inverse relationship, and are regulated in a coordinated manner during development. Embryonic

Two Cases of Kawasaki-Disease Who Showed Coronary Arterial Dilatation Even after Good Response to a Single High-dose Intravenous Immunoglobulin Infusion

It is now clear that a high-dose intravenous immunoglobulin therapy (IVIG) in patients with Kawasaki disease (KD) is effective for reducing the incidence of coronary arterial lesions (CAL). But both the total dose and the dose regimens of IVIG are still controversial.In this study, we report two cases with CAL in KD. These two cases were treated with aspirin (30mg/kg/day) and a...

Does Streptococcal Pyrogenic Exotoxin-C Trigger the Onset of Kawasaki Disease? -Association between Superantigens and Autoantibody against Vascular Smooth Muscle Cells-

I) T cell receptor (TCR) usage We investigated TCR usage and antibody responses to streptococcal pyrogenic exotoxin-C (SPE-C) in order to determine whether an association exists between SPE-C and the onset of Kawasaki disease (KD). Patients and Method Fifty-four patients with KD were studied. Analysis of TCR usage was performed by adaptor-ligation PCR and microplate hybridization...

Common variants in CASP3 confer susceptibility to Kawasaki disease

Yoshihiro Onouchi Kouichi Ozaki Jane C. Buns Chisato Shimizu Hiromichi Hamada Takafumi Honda Masaru Terai Akihito Honda Takashi Takeuchi Shoichi Shibuta Tomohiro Suenaga Hiroyuki Suzuki Kouji Higashi