YoshiokaDepartment of Virology and Parasitology, Hamamatsu University School of Medicine, Hamamatsu, JapanTetsuro Suzuki AuthorsSearch for Takayoshi Shirasaki in:Nature Research journals • PubMed • Google Scholar ... • PubMed • Google Scholar Search for Shuichi Kaneko in:Nature Research journals • PubMed • Google Scholar Contributions Takayoshi Shirasaki designed the study, performed the experiments, interpreted the
Murai Takayoshi Shirasaki Masaya Funaki Masao Honda Seishi Murakami MinkyungYi Hong Tang Shuichi Kaneko OPEN Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral
School of Medicine, Kanazawa, JapanMasao Honda, Takayoshi Shirasaki, Tetsuro Shimakami & Shuichi KanekoDepartment of Virology and Immunology, Texas Biomedical Research Institute and Southwest National ... Guerra in:Nature Research journals • PubMed • Google ScholarSearch for Takayoshi Shirasaki in:Nature Research journals • PubMed • Google ScholarSearch for Tetsuro Shimakami in:Nature Research journals
Background. Translation of the hepatitis C virus (HCV) is mediated by an internal ribosome entry site (IRES). Here, we analyzed the functional relevance of La protein for replication of HCV using an infectious HCV clone, JFH-1. Methods. A single-nucleotide mutation from A to U was introduced at the 338th nucleotide in the stem-loop domain IV structure of HCV IRES, which...