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The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

YoshiokaDepartment of Virology and Parasitology, Hamamatsu University School of Medicine, Hamamatsu, JapanTetsuro Suzuki AuthorsSearch for Takayoshi Shirasaki in:Nature Research journals • PubMed • Google Scholar ... • PubMed • Google Scholar Search for Shuichi Kaneko in:Nature Research journals • PubMed • Google Scholar Contributions Takayoshi Shirasaki designed the study, performed the experiments, interpreted the

Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems

Murai Takayoshi Shirasaki Masaya Funaki Masao Honda Seishi Murakami MinkyungYi Hong Tang Shuichi Kaneko OPEN Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

School of Medicine, Kanazawa, JapanMasao Honda, Takayoshi Shirasaki, Tetsuro Shimakami & Shuichi KanekoDepartment of Virology and Immunology, Texas Biomedical Research Institute and Southwest National ... Guerra in:Nature Research journals • PubMed • Google ScholarSearch for Takayoshi Shirasaki in:Nature Research journals • PubMed • Google ScholarSearch for Tetsuro Shimakami in:Nature Research journals

La Protein Required for Internal Ribosome Entry Site—Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication

Background. Translation of the hepatitis C virus (HCV) is mediated by an internal ribosome entry site (IRES). Here, we analyzed the functional relevance of La protein for replication of HCV using an infectious HCV clone, JFH-1. Methods. A single-nucleotide mutation from A to U was introduced at the 338th nucleotide in the stem-loop domain IV structure of HCV IRES, which...