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43 papers found.
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Association between serum ferritin levels and clinical outcomes in maintenance hemodialysis patients: a retrospective single-center cohort study

BackgroundFerritin is a well-known marker of iron deficiency anemia, but the target in maintenance hemodialysis (MHD) patients remains controversial. This study examined the association between baseline ferritin levels and clinical outcomes.MethodsWe retrospectively collected the data of outpatients on MHD for 5 years at St. Luke’s International Hospital from July 2009. Patients...

An innate interaction between IL-18 and the propeptide that inactivates its precursor form

Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated...

Two-year results after coronary stenting of small vessels in Japanese population using 2.25-mm diameter sirolimus-eluting stent with bioresorbable polymer: primary and long-term outcomes of CENTURY JSV study

Percutaneous coronary intervention (PCI) in coronary artery disease (CAD) with very small vessels remains challenging. The aim of this study is to evaluate the safety and effectiveness of the 2.25-mm diameter Ultimaster sirolimus-eluting stent in the treatment of Japanese patients with CAD due to lesions in very small vessels. The CENTURY JSV study is a prospective, multicentre...

Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression

for Toru Kita in:Nature Research journals • PubMed • Google Scholar Search for Takeshi Kimura in:Nature Research journals • PubMed • Google Scholar Search for Eiichiro Nishi in:Nature Research

Long-term use of carvedilol in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Miyake, Kurashiki Central Hospital; Kazuaki Kadota, Reo Hata, Shiga Medical Center for Adults; Shigeru Ikeguchi, Yasutaka Inuzuka, Kyoto University Hospital; Takeshi Kimura, Neiko Ozasa, Hiroki Watanabe ... Kozuma, Kanazawa Cardiovascular Hospital; Masanobu Namura, Kobe University Hospital; Toshiro Shinke. : Takeshi Kimura (principal investigator), Hiroshi Nonogi, Masakiyo Nobuyoshi

Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach

Chronic inflammation contributes to a wide variety of human disorders. In the stomach, longstanding gastritis often results in structural alterations in the gastric mucosa, including metaplastic changes and gastric cancers. Therefore, it is important to elucidate factors that are involved in gastric inflammation. Nardilysin (N-arginine dibasic convertase; Nrdc) is a...

Prognostic impact of final kissing balloon technique after crossover stenting for the left main coronary artery: from the AOI-LMCA registry

Department of Cardiology, Japanese Red Cross Society Wakayama Medical Center , Wakayama , Japan 2 Department of Cardiology, Chikamori Hospital , Kochi , Japan 3 Takeshi Kimura 4 Department of Cardiology ... the participating centers. Compliance with ethical standards Conflict of interest Takeshi Kimura serves as an advisory board member for Abbott Vascular. The other authors declare that they have no

Regulation of type 1 iodothyronine deiodinase by LXRα

The iodothyronine deiodinases are selenoenzymes that regulate the activity of thyroid hormone via specific inner- or outer-ring deiodination. In humans, type 1 deiodinase (D1) is highly expressed in the liver, but the mechanism by which its gene expression is regulated remains to be elucidated. Liver X receptor α (LXRα), a transcription factor of the nuclear receptor superfamily...

Risk of bleeding and repeated bleeding events in prasugrel-treated patients: a review of data from the Japanese PRASFIT studies

Co., Ltd., MSD K.K., and Sanofi K.K., and patent fees from NIPRO Corporation; Takeshi Kimura has received honoraria, clinical research funding, and other research funding from Daiichi Sankyo Co, Ltd

Safety and effectiveness of controlled-release paroxetine in routine clinical practice: results of a postmarketing surveillance study of patients with depression

Takeshi Kimura,3 Terufumi Hara3 1Department of Neuropsychiatry, Kansai Medical University, Moriguchi-shi, Osaka, Japan; 2Medical Affairs, 3Clinical Safety and PMS, Development and Medical Affairs Division ... , Shionogi, and Ono Since ADRs of SSRIs tend to occur during the early stage Pharmaceutical within the past 3 years. Toshifumi Kimura, of treatment, longer exposure to paroxetine may result in Takeshi Kimura

Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

It is unknown how much different are the clinical outcomes between asymptomatic and symptomatic patients with severe aortic stenosis (AS). In the CURRENT AS registry enrolling 3,815 consecutive patients with severe AS, we compared the long-term outcomes between 1808 asymptomatic and 1215 symptomatic patients (exertional dyspnea: N = 813, syncope: N = 136, and angina: N = 266...

Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model

Background Despite recent progress with drug-eluting stents, restenosis and thrombosis after endovascular intervention are still major limitations in the treatment of cardiovascular diseases. These problems are possibly caused by inappropriate inhibition of neointimal formation and retardation of re-endothelialization on the surface of the stents. miR-126 has been shown to have...

Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease

Background The genetic architecture of coronary artery disease has not been fully elucidated, especially in Asian countries. Moyamoya disease is a progressive cerebrovascular disease that is reported to be complicated by coronary artery disease. Because most Japanese patients with moyamoya disease carry the p.R4810K variant of the ring finger 213 gene (RNF213), this may also be a...

Hypothesis of Long-Term Outcome after Coronary Revascularization in Japanese Patients Compared to Multiethnic Groups in the US

Background Ethnicity has a significant impact on coronary artery disease (CAD). This study investigated the long-term outcomes of Japanese patients undergoing revascularization compared with US patients belonging to multiple ethnic groups. Methods and Results We evaluated clinical outcomes, based on ethnicity, of patients included in the Coronary Revascularization Demonstrating...

Association of Localized Hypersensitivity and In-Stent Neoatherosclerosis with the Very Late Drug-Eluting Stent Thrombosis

Background Localized hypersensitivity reaction, delayed arterial healing, and neoatherosclerosis inside the stent have been suggested as the underlying pathologic mechanisms of very late stent thrombosis (VLST) of drug-eluting stent (DES). The present study sought to explore the prevalence of inflammatory cell infiltrates and evidence for fragments of atherosclerotic plaques in...

Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia

Kimura 1 2 0 Kyoto University iPS Cell Research and Application, Kyoto, Japan, 3 Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science , Otsu , Japan , 4 Department of

Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography

The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment...

Causes of Death in Patients with Severe Aortic Stenosis: An Observational study

Takeshi Kimura in:Nature Research journals • PubMed • Google Scholar Contributions Kato T. had full access to all the data in the study and takes responsibility for the integrity of the data and the

Measurement of Technetium-99m Sestamibi Signals in Rats Administered a Mitochondrial Uncoupler and in a Rat Model of Heart Failure

Background Many methods have been used to assess mitochondrial function. Technetium-99m sestamibi (99mTc-MIBI), a lipophilic cation, is rapidly incorporated into myocardial cells by diffusion and mainly localizes to the mitochondria. The purpose of this study was to investigate whether measurement of 99mTc-MIBI signals in animal models could be used as a tool to quantify...

Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery

Background Recently, it has been reported that specific microRNA (miRNA) levels are elevated in serum and can be used as biomarkers in patients with cardiovascular diseases. However, miRNAs expression profiles and their sources in pericardial fluid (PF) are unclear. Methods and Results The purpose of this study was to identify the levels of miRNAs in PF in relation to those in...