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Associations of obstructive sleep apnea with truncal skeletal muscle mass and density

: Dr. Takeshi Matsumoto reports grants from japan Foundation for Neuroscience and Mental Health, during the conduct of the study. Dr. Kiminobu Tanizawa reports grants from the Japanese Ministry of

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

PurposeThe purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction.MethodsThis was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized...

Combined association of clinical and lifestyle factors with non-restorative sleep: The Nagahama Study

Background Non-restorative sleep (NRS) was suggested to be associated with cardiovascular outcomes. However, causative factors for NRS have not been fully elucidated. This study aimed to clarify factors and their relationships with NRS to better understand the clinical and epidemiological implications of NRS and to develop a score that can objectively evaluate NRS status. Methods...

Subtraction micro-computed tomography of angiogenesis and osteogenesis during bone repair using synchrotron radiation with a novel contrast agent

Division, Osaka University Graduate School of Engineering Science, Toyonaka, JapanTakeshi Matsumoto, Daichi Goto & Syota Sato AuthorsSearch for Takeshi Matsumoto in:Nature Research journals • PubMed • Google ... of interest. Corresponding author Correspondence to Takeshi Matsumoto. Rights and permissions To obtain permission to re-use content from this article visit RightsLink. About this article

Role of sedation for agitated patients undergoing noninvasive ventilation: clinical practice in a tertiary referral hospital

Background Although sedation is often required for agitated patients undergoing noninvasive ventilation (NIV), reports on its practical use have been few. This study aimed to evaluate the efficacy and safety of sedation for agitated patients undergoing NIV in clinical practice in a single hospital. Methods We retrospectively reviewed sedated patients who received NIV due to acute...

Critical Role of Exogenous Nitric Oxide in ROCK Activity in Vascular Smooth Muscle Cells

Objective Rho-associated kinase (ROCK) signaling pathway has been shown to mediate various cellular functions including cell proliferation, migration, adhesion, apoptosis, and contraction, all of which may be involved in pathogenesis of atherosclerosis. Endogenous nitric oxide (NO) is well known to have an anti-atherosclerotic effect, whereas the exogenous NO-mediated...

Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model

Background The purpose of this study was to determine whether autologous mesenchymal stem cells (MSCs) implantation improves endothelial dysfunction in a rabbit ischemic limb model. Methods We evaluated the effect of MSC implantation on limb blood flow (LBF) responses to acetylcholine (ACh), an endothelium-dependent vasodilator, and sodium nitroprusside (SNP), an endothelium...