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Prediction model for pancreatic cancer risk in the general Japanese population

Contributions Conceptualization: Masahiro Nakatochi, Yingsong Lin, Chaochen Wang, Takeshi Nishiyama, Shogo Kikuchi, Keitaro Matsuo. Formal analysis: Masahiro Nakatochi, Fumie Kinoshita, Yumiko Kobayashi ... , Takashi Sasaki, Naoki Sasahira, Manabu Morimoto, Satoshi Kobayashi, Makoto Ueno, Shinichi Ohkawa, Naoto Egawa, Sawako Kuruma, Mitsuru Mori, Haruhisa Nakao, Chaochen Wang, Takeshi Nishiyama, Takahisa

Microaneurysms cause refractory macular edema in branch retinal vein occlusion

Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational case-control study. Twenty eyes received a sub-Tenon’s capsule...

Association between shift work and the risk of death from biliary tract cancer in Japanese men

Background There is increasing evidence suggesting that shift work involving night work may increase cancer risk. Methods We examined the association between working rotating shifts and the risk of death from biliary tract cancer among Japanese men who participated in the Japan Collaborative Cohort Study. Of the 46,395 men recruited, 22,224 men aged 40–65 at baseline (1988–1990...

A failure to confirm the effectiveness of a brief group psychoeducational program for mothers of children with high-functioning pervasive developmental disorders: a randomized controlled pilot trial

Masako Suzuki,1 Atsurou Yamada,1 Norio Watanabe,1 Tatsuo Akechi,1 Fujika Katsuki,2 Takeshi Nishiyama,3 Masayuki Imaeda,4 Taishi Miyachi,4 Kazuo Otaki,5 Yumiko Mitsuda,6 Akino Ota,6 Toshi A Furukawa7

Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

Background Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects. Methods Our case-control study involved 360 newly diagnosed pancreatic cancer cases and 400 frequency-matched, non-cancer control subjects. We genotyped four folate...

Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects. Our case-control study involved 360 newly diagnosed pancreatic cancer cases and 400 frequency-matched, non-cancer control subjects. We genotyped four folate metabolizing gene...

Organizing pneumonia after stereotactic ablative radiotherapy of the lung

Background Organizing pneumonia (OP), so called bronchiolitis obliterans organizing pneumonia after postoperative irradiation for breast cancer has been often reported. There is little information about OP after other radiation modalities. This cohort study investigated the clinical features and risk factors of OP after stereotactic ablative radiotherapy of the lung (SABR...

Major contribution of dominant inheritance to autism spectrum disorders (ASDs) in population-based families

Results of twin studies have shown that autism spectrum disorders (ASDs) are attributable to complex multigenic interactions rather than to a single susceptibility gene. However, the growing number of distinct, individually rare genetic causes of ASDs, mostly copy number variations (CNVs), favors an alternative to the polygenic hypothesis, the two-component model, which suggests...

A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data

Background Several statistical tests have been developed for analyzing genome-wide association data by incorporating gene pathway information in terms of gene sets. Using these methods, hundreds of gene sets are typically tested, and the tested gene sets often overlap. This overlapping greatly increases the probability of generating false positives, and the results obtained are...

Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs)

, JapanSatoshi Sumi AuthorsSearch for Takeshi Nishiyama in:Nature Research journals • PubMed • Google ScholarSearch for Hitomi Taniai in:Nature Research journals • PubMed • Google ScholarSearch for Taishi Miyachi ... ScholarSearch for Satoshi Sumi in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Takeshi Nishiyama. Supplementary information Word documents1.Supplementary Figure 1

Detailed Analysis of Japanese Population Substructure with a Focus on the Southwest Islands of Japan

Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we...