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Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries

Hydrazine-embedded heterocyclic compounds with dimeric dimethylacridine (1b), carbazole (2b), and phenothiazine (3b) skeletons were applied to cathode active materials of rechargeable lithium organic batteries, and the performance of the batteries was evaluated. The charge/discharge curves exhibited clear plateaus in the high voltage range of 3.3–3.7 V. The capacities of the...

Thiamine tetrahydrofurfuryl disulfide promotes voluntary activity through dopaminergic activation in the medial prefrontal cortex

Kashibe Takeru Shima Takeshi Shimizu Takehiro Naruto Takahito Kitayoshi Kouji Akimoto Shinji Ninomiya A physically active lifestyle is associated with better health in body and mind, and it is urgent that

Short-term outcome of percutaneous coronary intervention with directional coronary atherectomy followed by drug-coated balloon: a preliminary report

Directional coronary atherectomy (DCA) is a unique technique used in percutaneous coronary intervention (PCI) which involves the removal of plaque from the coronary artery. Treatment with a drug-coated balloon (DCB) appears to be effective, especially when a predilatation of the lesion is performed appropriately. We hypothesize that the combination therapy of DCA with DCB is an...

IQ·SPECT technology and its clinical applications using multicenter normal databases

IQ·SPECT (Siemens Medical Solutions) is a solution for high-sensitivity and short-time acquisition imaging of the heart for a variable angle general purpose gamma camera. It consists of a multi-focal collimator, a cardio-centric orbit and advanced iterative reconstruction, modeling the image formation physics accurately. The multi-focal collimator enables distance-dependent...

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

Takeshi Shimizu Nobumoto Watanabe Hiroyuki Osada OPEN Mammalian p38 mitogen activated protein kinases (MAPKs) are responsive to a variety of cellular stresses. The development of specific pyridinyl

Proteomic profiling reveals that collismycin A is an iron chelator

, JapanMakoto Kawatani, Makoto Muroi, Yushi Futamura, Harumi Aono, Kenshirou Shimizu, Takeshi Shimizu & Hiroyuki OsadaNonnatural Amino Acid Technology Team, RIKEN CLST, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama ... Shimizu in:Nature Research journals • PubMed • Google ScholarSearch for Takeshi Shimizu in:Nature Research journals • PubMed • Google ScholarSearch for Yasuhiro Igarashi in:Nature Research journals • PubMed

Induced sensorimotor brain plasticity controls pain in phantom limb patients

University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTakufumi Yanagisawa, Ryohei Fukuma, Koichi Hosomi, Haruhiko Kishima, Takeshi Shimizu, Masayuki Hirata, Toshiki Yoshimine ... Hosomi, Takeshi Shimizu & Youichi SaitohDepartment of Mechanical Engineering and Intelligent Systems, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, JapanHiroshi

Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells

, Otsu, Shiga 520-2192, Japan Received 16 January 2012; Revised 27 February 2012; Accepted 2 March 2012 Academic Editor: Kazuhito Asano Copyright © 2012 Takeshi Shimizu and Shino Shimizu. This is an

Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16 INK4a in sinonasal diseases

Background We aimed to clarify the possible role of human papillomavirus (HPV) infection in the malignant transformation of sinonasal inverted papilloma (IP). Methods Subjects comprised 32 patients with chronic rhinosinusitis (CRS), 17 with IP, 5 with IP and squamous cell carcinoma (IP + SCC), and 16 with primary sinonasal SCC. HPV presence, viral loads, and physical status were...

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2

In higher eukaryotes, RAD51 functions as an essential protein in homologous recombination and recombinational repair of DNA double strand breaks. During these processes, RAD51 catalyzes homologous pairing between single-stranded DNA and double-stranded DNA. Japonica cultivars of rice (Oryza sativa) encode two RAD51 proteins, RAD51A1 and RAD51A2, whereas only one RAD51 exists in...

Impact of Sleep-Disordered Breathing on Heart Rate Turbulence in Heart Failure Patients

Background Sleep-disordered breathing (SDB) is associated with adverse outcomes in patients with chronic heart failure (CHF). Additionally, heart rate turbulence (HRT) reflects changes in the sinus cycle length of baroreceptor in response to hemodynamic fluctuations after ventricular premature beat. Recent studies have suggested that HRT as a marker of vagal activity has a...

MUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer

We have previously reported that MUC4 expression is a poor prognostic factor in various carcinomas. Our previous study also showed that MUC1 expression in gastric cancers, including the early and advanced stages is a poor prognostic factor. In the present study, the expression profiles of MUC4 and MUC1 were examined by immunohistochemistry (IHC) using two anti-MUC4 monoclonal...

A novel anti-MUC1 antibody against the MUC1 cytoplasmic tail domain: use in sensitive identification of poorly differentiated cells in adenocarcinoma of the stomach

Background Isolated cancer cells of non-solid type poorly differentiated adenocarcinoma (por2) or signet-ring cell carcinoma (sig) are frequently seen in scirrhous gastric cancers with a very poor prognosis. These cells are often scattered in granulation tissue or desmoplastic fibrotic tissue and tend to be overlooked in routine pathological examination. We aimed to raise a novel...

Specific Egg Yolk Immunoglobulin as a New Preventive Approach for Shiga-Toxin-Mediated Diseases

Shiga toxins (Stxs) are involved in the development of severe systemic complications associated with enterohemorrhagic Escherichia coli (EHEC) infection. Various neutralizing agents against Stxs are under investigation for management of EHEC infection. In this study, we immunized chickens with formalin-inactivated Stx-1 or Stx-2, and obtained immunoglobulin Y (IgY) from the egg...

Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain

Takeshi Shimizu 1 Masato Nakazawa Shuichi Kani Young-Ki Bae 0 Takashi Shimizu RyoichiroKageyama Masahiko Hibi () 0 Present address: Division of Cancer Biology, Research Institute, National Cancer

Liver Dysfunction Assessed by Model for End-Stage Liver Disease Excluding INR (MELD-XI) Scoring System Predicts Adverse Prognosis in Heart Failure

Aims Liver dysfunction due to heart failure (HF) is often referred to as cardiac or congestive hepatopathy. The composite Model for End-Stage Liver Disease excluding INR (MELD-XI) is a robust scoring system of liver function, and a high score is associated with poor prognosis in advanced HF patients with a heart transplantation and/or ventricular assist device. However, the...

Memory Immune Responses against Pandemic (H1N1) 2009 Influenza Virus Induced by a Whole Particle Vaccine in Cynomolgus Monkeys Carrying Mafa-A1*052∶02

We made an H1N1 vaccine candidate from a virus library consisting of 144 ( = 16 HA×9 NA) non-pathogenic influenza A viruses and examined its protective effects against a pandemic (2009) H1N1 strain using immunologically naïve cynomolgus macaques to exclude preexisting immunity and to employ a preclinical study since preexisting immunity in humans previously vaccinated or infected...

Early Skin Reaction Following 250 MeV Proton Peak Irradiation

Early skin reactions were observed on mouse legs irradiated in the spread out Bragg peak (SOBP) of a 250MeV proton beam, and the unmodified Bragg peak of that beam, or 290kVp X-rays. The fifty percent moist desquamation doses for the proton SOBP, proton peak, and for X-rays were 29.7Gy, 24.5 Gy, and 21.9Gy, respectively. The Bragg peak caused more severe early skin reactions than...