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X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and subsequently up-regulate its expression, and also to attempt to suppress the malignant biological...

PRDM16 functions as a suppressor of lung adenocarcinoma metastasis

The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been well addressed. Here we investigated the impact of PRDM16 on tumor growth and metastasis in lung cancer. UALCAN database, immunoblotting and immunohistochemistry analysis...

A cardiac risk score based on sudomotor function to evaluate cardiovascular autonomic neuropathy in asymptomatic Chinese patients with diabetes mellitus

, Weigang Zhao. Investigation: Tao Yuan, Jiapei Li, Yong Fu, Juan Li, Xiangqing Wang, Ying Zhou, Yingyue Methodology: Tao Yuan, Jiapei Li, Tao Xu, Weigang Zhao. Project administration: Tao Yuan, Weigang

Online Sequential Extreme Learning Machine with Generalized Regularization and Adaptive Forgetting Factor for Time-Varying System Prediction

Many real world applications are of time-varying nature and an online learning algorithm is preferred in tracking the real-time changes of the time-varying system. Online sequential extreme learning machine (OSELM) is an excellent online learning algorithm, and some improved OSELM algorithms incorporating forgetting mechanism have been developed to model and predict the time...

A Novel Hybrid Algorithm for Solving Multiobjective Optimization Problems with Engineering Applications

An effective hybrid algorithm is proposed for solving multiobjective optimization engineering problems with inequality constraints. The weighted sum technique and BFGS quasi-Newton’s method are combined to determine a descent search direction for solving multiobjective optimization problems. To improve the computational efficiency and maintain rapid convergence, a cautious BFGS...

A Novel Hybrid Algorithm for Solving Multiobjective Optimization Problems with Engineering Applications

An effective hybrid algorithm is proposed for solving multiobjective optimization engineering problems with inequality constraints. The weighted sum technique and BFGS quasi-Newton’s method are combined to determine a descent search direction for solving multiobjective optimization problems. To improve the computational efficiency and maintain rapid convergence, a cautious BFGS...

Estimating in situ rock mass strength and elastic modulus of granite from the Soultz-sous-Forêts geothermal reservoir (France)

. Heap Alexandra R. L. Kushnir Tao Qin Patrick Baud Guanglei Zhou Tao Xu Knowledge of the strength and elastic modulus of a reservoir rock is important for the optimisation of a particular geothermal

Case–Control Study of Inflammatory Bowel Disease Patients with and without Clostridium difficile Infection and Poor Outcomes in Patients Coinfected with C. difficile and Cytomegalovirus

Background and AimsClostridium difficile infection (CDI) incidence and risk factors in patients with inflammatory bowel disease (IBD) have been extensively studied. However, data describing CDI in Chinese patients with IBD are limited. We investigated the cumulative incidence, risk factors, and outcomes of CDI in Chinese IBD patients.MethodsWe conducted a retrospective, case...

Corrigendum to “New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy”

Yuan Yuan,1,2 Rui Liu,2 Tao Xu,3 Huamin Wei,2 Xinyao Xu,1,2 Shulin He,1,2 Shuntai Chen,1,2 Zhan Shi,4 Wei Hou,2 and Baojin Hua2 1Beijing University of Chinese Medicine, No. 11 North Third Ring Road East

Corrigendum to “New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy”

Yuan Yuan,1,2 Rui Liu,2 Tao Xu,3 Huamin Wei,2 Xinyao Xu,1,2 Shulin He,1,2 Shuntai Chen,1,2 Zhan Shi,4 Wei Hou,2 and Baojin Hua2 1Beijing University of Chinese Medicine, No. 11 North Third Ring Road East

Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex

interneurons. Conflicts of Interest The authors declare that they have no conflict of interest. Authors’ Contributions Congli Liu and Tao Xu contributed equally to this article. Acknowledgments This work was

Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex

interneurons. Conflicts of Interest The authors declare that they have no conflict of interest. Authors’ Contributions Congli Liu and Tao Xu contributed equally to this article. Acknowledgments This work was

Crashworthiness Design for Bionic Bumper Structures Inspired by Cattail and Bamboo

Received 28 April 2017; Revised 17 August 2017; Accepted 19 September 2017; Published 8 October 2017 Academic Editor: Saurabh Das Copyright © 2017 Tao Xu et al. This is an open access article distributed

Activation of spinal dorsal horn P2Y13 receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain

Activation of spinal dorsal horn P2Y13 receptors can promote the expression of IL-1beta and IL-6 in rats with diabetic neuropathic pain Rui Zhou,* Tao Xu,* XiaoHong Liu, YuanShou Chen, DeYing Kong ... Journal of Pain Research activation of spinal dorsal horn P2Y receptors 13 can promote the expression of il-1 β and il-6 in rats with diabetic neuropathic pain Rui Zhou 0 Tao Xu 0 0 Department of

Ray tracing of turning wave in elliptically anisotropic media with an irregular surface

Seismic ray tracing in anisotropic media with irregular surface is crucial for the exploration of the fine crustal structure. Elliptically anisotropic medium is the type of anisotropic media with only four independent elastic parameters. Usually, this medium can be described by only the vertical phase velocity and the horizontal phase velocity for seismic wave propagation. Model...

Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

each study by two authors (Jingzhu Lv and Tao Xu): the first author’s name, year of publication, country, genotyping method, number of cases and controls, genotype, and allele frequency. After extraction

Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

each study by two authors (Jingzhu Lv and Tao Xu): the first author’s name, year of publication, country, genotyping method, number of cases and controls, genotype, and allele frequency. After extraction

Lasing and Transport Properties of Poly[(9,9-dioctyl-2,7-divinylenefluorenylene)-alt-co-(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene)] (POFP) for the Application of Diode-Pumped Organic Solid Lasers

This paper demonstrates the lasing and transport properties of a green conjugated polymer, namely POFP. High photoluminescence yields and excellent electron transport of POFP film make it promising for gain media. Low threshold value of 4.0 μJ/cm2 for amplified spontaneous emissions under a pulsed Nd:YAG laser at 355 nm was obtained, as well as a high Q-factor of 159. An inverted...