Gene expression is regulated by orchestrated binding of regulatory proteins to promoters and other cis-regulatory DNA elements (CREs). Several plant databases have been developed for mapping promoters or DNA motifs associated with promoters. However, there is a lack of databases that allow investigation for all CREs. Here we present PlantDHS (http://plantdhs.org), a plant DNase I...
Hepatitis B virus X protein (HBx) contributes to the development of hepatocellular carcinoma (HCC) through inducing dysregulation of lipogenesis. However, the mechanism by which HBx induces the abnormal lipogenesis is not well known. In this study, we report that the oncogene Rab18, a member of Ras family, enhances the HBx-induced hepatocarcinogenesis through inducing...
TAR DNA-binding protein 43 (TDP-43) plays a key role in the neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The nature of the TDP-43-mediated neurotoxicity associated with these diseases is not yet understood. Here, we have established transgenic Caenorhabditis elegans models that express human TDP-43 variants in the...
Distribution, egg production rate (EPR) and abundances of four small copepods in genera Paracalanus and Acartia were studied monthly from October 2005 to September 2006 in and outside Jiaozhou Bay, China. Biomass and secondary production also were calculated to show the importance of these small copepods. As predominant species, Paracalanus parvus and Acartia bifilosa, occurred...
It has been proposed that the genetic variants of IVS8 c.1210-12T[5_9] and adjacent c.1210-35_1210-12GT[8_12] in cystic fibrosis transmembrane conductance regulator gene might contribute to the spermatogenetic failure, but numerous genetic association studies that aimed to test this hypothesis reported conflicting results. So, in order to clarify such inconsistencies, we first...
GUANG-TAO ZHANG 0 SONG SUN 0 BO YANG 0 0 KEY LABORATORY OF MARINE ECOLOGY AND ENVIRONMENTAL SCIENCES We have observed that Calanus sinicus retreated from neritic areas in the Yellow Sea and
GUANG-TAO ZHANG 0 SONG SUN 0 FANG ZHANG 0 0 KEY LABORATORY OF MARINE ECOLOGY & ENVIRONMENTAL SCIENCES Annual variations of egg production rate (EPR) and clutch size of Calanus sinicus, as well as
MicroRNAs are endogenous small RNA molecules that regulate gene expression. Although the biogenesis of microRNAs and their regulation have been thoroughly elucidated, the degradation of microRNAs has not been fully understood. Here by using the pulse–chase approach, we performed the direct measurement of microRNA lifespan. Five representative microRNAs demonstrated a general...
Iron is a critical cofactor for a number of metalloenzymes involved in respiration and photosynthesis, but plants often suffer from iron deficiency due to limited supplies of soluble iron in the soil. Iron deficiency induces a series of adaptive responses in various plant species, but the mechanisms by which they are triggered remain largely unknown. Using pH imaging and hormone...
Subchronic exposure to arsenic increases the incidence of human cancers such as skin, lung, colon, and rectal cancer. The mechanism for arsenic-induced tumorigenesis is still not clear. It is generally believed that DNA damage and genomic instability, generated by arsenic-promoted oxidative stress, account largely for this process. The major sources of reactive oxygen species...
Transcriptional activation of enhancer and σ54-dependent promoters requires efficient interactions between enhancer-binding proteins (EBP) and promoter bound σ54-RNA polymerase (Eσ54) achieved by DNA looping, which is usually facilitated by the integration host factor (IHF). Since the lengths of the intervening region supporting DNA-loop formation are similar among IHF-dependent...
Many chronic human immunodeficiency virus (HIV) patients suffer from gastric complaints, including gastric tuberculosis and coinfection of other pathogens. Recent work has demonstrated that a variety of nonimmune cells can act as viral reservoirs, even at the early stage of HIV infection. In this study, we detect HIV viral particles, proteins, and nucleic acids in gastric...
Ecological and physiological features of the planktonic copepod Calanus sinicus in the southern Yellow Sea in summer were studied to reveal its life history strategy. From the coastal shallow waters to the central part of the southern Yellow Sea, a shift of the stage composition occurs from being dominated by the egg-nauplius stage to being dominated by the fifth copepodite (CV...
Feng ZHANG Tao ZHANG Zhong-Ping GU Yong-An ZHOU Yong HAN Xiao-Fei LI Xiao-Ping WANG Qing-Shu CHENG Qi-Bing MEI Roscovitine/A549 cells/Ionizing radiation/Apoptosis/Caspase-3/DNA repair. Roscovitine
