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Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report

Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic...

The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

Honda, Taro Yamashita, Kouki Nio, Tetsuro Shimakami, Ryougo Shimizu, Saki Nakasyo, Kazuhisa Murai, Natsumi Shirasaki, Hikari Okada, Yoshio Sakai & Shuichi KanekoDepartment of Advanced Medical Technology ... Search for Masao Honda in:Nature Research journals • PubMed • Google Scholar Search for Taro Yamashita in:Nature Research journals • PubMed • Google Scholar Search for Kouki Nio in:Nature Research

Polarization insensitive frequency conversion for an atom-photon entanglement distribution via a telecom network

Miki Masahiro Yabuno Taro Yamashita Hirotaka Terai Masato Koashi Tetsuya Mukai Takashi Yamamoto Nobuyuki Imoto Long-lifetime quantum storages accessible to the telecom photonic infrastructure are

High-fidelity entanglement swapping and generation of three-qubit GHZ state using asynchronous telecom photon pair sources

We experimentally demonstrate a high-fidelity entanglement swapping and a generation of the Greenberger-Horne-Zeilinger (GHZ) state using polarization-entangled photon pairs at telecommunication wavelength produced by spontaneous parametric down conversion with continuous-wave pump light. While spatially separated sources asynchronously emit photon pairs, the time-resolved photon...

Localized primary amyloidosis of the breast: a case report and review of the literature

Background Primary amyloidosis of the breast is an unusual benign disease that mostly occurs in postmenopausal elderly women. Amyloidosis is the deposition of amorphous protein within tissues. Breast biopsy is necessary to make a definite diagnosis in order to avoid unnecessary surgical methods. Localized primary amyloidosis of the breast has a good prognosis. However, secondary...

Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B

, Yasunari Nakamoto. Investigation: Takuto Nosaka, Tatsushi Naito, Katsushi Hiramatsu, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Marusawa, Ning Ma, Yusuke Hiraku, Shosuke Kawanishi, Taro Yamashita, Shuichi

Superconducting nanowire single-photon detectors with non-periodic dielectric multilayers

We present superconducting nanowire single-photon detectors (SSPDs) on non-periodic dielectric multilayers, which enable us to design a variety of wavelength dependences of optical absorptance by optimizing the dielectric multilayer. By adopting a robust simulation to optimize the dielectric multilayer, we designed three types of SSPDs with target wavelengths of 500 nm, 800 nm...

Inflammatory state exists in familial amyloid polyneuropathy that may be triggered by mutated transthyretin

The relationship between familial amyloid polyneuropathy (FAP), which is caused by mutated transthyretin (TTR), and inflammation has only recently been noted. To determine whether inflammation is present in FAP carriers and patients, serum interleukin (IL)−6 concentration in 57 healthy donors (HD), 21 FAP carriers, and 66 FAP patients was examined, with the relationship between...

Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus

Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko. Resources: Koichiro Matsuda, Taku Sanada, Takeshi Urabe, Katsuhisa Inamura, Takashi

Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells

Hepatocellular carcinoma (HCC) is one of the world’s most aggressive diseases and carries a poor prognosis for patients. Recent evidence suggests that HCC is organized by cancer stem cells (CSCs), which are a subset of cells with stem cell-like features. CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been investigated using various stem...

Detection-dependent six-photon Holland-Burnett state interference

The NOON state, and its experimental approximation the Holland-Burnett state, have important applications in phase sensing measurement with enhanced sensitivity. However, most of the previous Holland-Burnett state interference (HBSI) experiments only investigated the area of the interference pattern in the region immediately around zero optical path length difference, while the...

Tumor-suppressive effects of atelocollagen-conjugated hsa-miR-520d-5p on un-differentiated cancer cells in a mouse xenograft model

Background We previously demonstrated that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via a demethylation process and p53 upregulation in vivo. Additionally, we have reported the non-tumorigenic effect of miR-520d-5p on normal human cells, including fibroblasts. Methods We used atelocollagen-conjugated miR...

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

Background We investigated the contribution of subsequent therapy for advanced hepatocellular carcinoma refractory or intolerant to sorafenib. Further, we investigated the impact of sorafenib on overall survival using individual data. Methods We reviewed the medical records of patients with advanced hepatocellular carcinoma treated with sorafenib. Survival after sorafenib...

Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib

effects of sorafenib Takeshi Yamada 0 Masato Abei 0 Inaho Danjoh Ryoko Shirota Taro Yamashita Ichinosuke Hyodo 0 Yukio Nakamura 0 Division of Gastroenterology, Faculty of Medicine, University of Tsukuba

Hsa-miR-520d Converts Fibroblasts into CD105+ Populations

designed the experiments; Yoshitaka Ishihara, Satoshi Tsuno, Taro Yamashita, and Yusuke Endo performed the experiments; Satoshi Tsuno and Norimasa Miura analyzed the data; Satoshi Tsuno contributed reagents

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Background The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little has been documented about the mechanism by which peretinoin exerts its inhibitory effects against recurrent HCC in humans in vivo. Methods Twelve hepatitis C...

Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature

Akihiko Ueda Takayuki Kosaka Satoshi Yamashita En Kimura Taro Yamashita Yasushi Maeda Teruyuki Hirano Makoto Uchino A 56-year-old man noticed discomfort in his left lower limb, followed by convulsion and

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners

manuscript. Competing Interests: Prof. Osamu Yokosuka received grant support from Mitsubishi Tanabe Pharma. Dr. Taro Yamashita, an academic editor of PLOS ONE, is listed as a co-author of the manuscript. This

Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas

ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors. As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysine 4 of histone H3 (H3K4me3) to regulate chromatin modification and gene expression. ING2 also functionally interacts with the tumor suppressor protein p53 to...

Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells

In response to antigen stimulation, Th cells differentiate into two types of effector cells, Th1 and Th2. Th1 cells predominantly mediate cellular immunity, whereas Th2 cells induce humoral allergic responses. We have conducted here serial analysis of gene expression (SAGE) in human activated Th1- and Th2-polarized cells from cord blood. SAGE analysis of 64,510 tags (32,219 and...