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Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

Background The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset of typical AD symptoms. Functional MRI (fMRI) is a brain imaging technique that has been used to demonstrate hippocampal activation during measurement of...

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

AuthorsSearch for Taylor W. Schmitz in:Nature Research journals • PubMed • Google ScholarSearch for R. Nathan Spreng in:Nature Research journals • PubMed • Google Scholar Contributions ADNI collected the data ... Correspondence to Taylor W. Schmitz. Supplementary information PDF files1.Supplementary Information Supplementary Table 1 2.Peer Review File Rights and permissions This work is licensed under a