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Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment

Podocytes are highly specialized cells that line the glomerulus of the kidney and play a role in filtration. Podocyte injury plays a critical role in the development of many kidney diseases, but the underlying mechanisms remain unclear. In this study, we identified that neurofilament heavy polypeptide (NEFH), an intermediate filament component, protects podocyte from injury. We...

Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis

Rac1, a Rho family member, is ubiquitously expressed and participates in various biological processes. Rac1 expression is induced early in podocyte injury, but its role in repair is unclear. To investigate the role of Rac1 expression in podocytes under pathological conditions, we used podocyte-specific Rac1 conditional knock-out (cKO) mice administered adriamycin (ADR), which...

Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte

Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, JapanYu Sasaki, Teruo Hidaka, Miyuki Akiba-Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Yoshiko Nagai-Hosoe, Eriko Tanaka, Satoshi ... Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, JapanEriko Tanaka AuthorsSearch for Yu Sasaki in:Nature Research journals • PubMed • Google ScholarSearch for Teruo Hidaka

Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy

Podocytes serve as the final barrier to urinary protein loss through a highly specialized structure called a slit membrane and maintain foot process and glomerular basement membranes. Podocyte injury results in progressive glomerular damage and accelerates sclerotic changes, although the exact mechanism of podocyte injury is still obscure. We focus on the staining gap (podocin...

Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy

Background It has been reported that podocytopenia has been occurring with increasing disease severity in patients with IgA nephropathy (IgAN). Dendrin is localized at the slit diaphragm (SD) in podocytes. We showed that dendrin translocates to the nucleus of injured podocytes in experimental nephritis and the nuclear dendrin promotes podocyte apoptosis. It is still unknown...

Notch2 activation ameliorates nephrosis

, Takuto Seki, Kanae Nonaka, Rin Asao, Yoshiko Nagai-Hosoe, Miyuki Akiba-Takagi, Teruo Hidaka & Yasuhiko TominoDepartment of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical ... for Miyuki Akiba-Takagi in:Nature Research journals • PubMed • Google ScholarSearch for Teruo Hidaka in:Nature Research journals • PubMed • Google ScholarSearch for Masatoshi Takagi in:Nature Research