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Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques

Conceptualization: Nelson Chao, J. Mark Cline, Thomas C. Register, Gregory D. Sempowski. Data curation: Laura P. Hale, J. Mark Cline, Thomas C. Register, Gregory D. Sempowski. Formal analysis: Laura P. Hale, Chen ... C. Register. Methodology: Gowrisankar Rajam, George M. Carlone, Greg Dugan, David Caudell, J. Mark Cline, Thomas C. Register. Project administration: Gregory D. Sempowski. Resources: Gregory D

In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure

Safe clinical hormone replacement (HR) will likely become increasingly important in the growing populations of aged women and cancer patients undergoing treatments that ablate the ovaries. Cell-based HRT (cHRT) is an alternative approach that may allow certain physiological outcomes to be achieved with lower circulating hormone levels than pharmacological means due to...

Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes

. Wagenknecht, Barry I. Freedman. Funding acquisition: Barry I. Freedman. Methodology: Jasmin Divers, Thomas C. Register, Leon Lenchik. Project administration: S. Carrie Smith, Donald W. Bowden, Barry I ... . Russell, Carl D. Langefeld, Lynne E. Wagenknecht, Jianzhao Xu, S. Carrie Smith, Donald W. Bowden, Thomas C. Register, J. Jeffrey Carr, Leon Lenchik. 9 / 11 10 / 11 1. Ding J , Hsu FC , Harris TB , Liu Y

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer’s disease. In this study of nonhuman primates, we focus on...

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer’s disease. In this study of nonhuman primates, we focus on...

Ten-Year Trends in Coronary Calcification in Individuals without Clinical Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis

Background Coronary heart disease (CHD) incidence has declined significantly in the US, as have levels of major coronary risk factors, including LDL-cholesterol, hypertension and smoking, but whether trends in subclinical atherosclerosis mirror these trends is not known. Methods and Findings To describe recent secular trends in subclinical atherosclerosis as measured by serial...

Beyond Breast Cancer: Mammographic Features and Mortality Risk in a Population of Healthy Women

BackgroundBreast fibroglandular (dense) tissue is a risk factor for breast cancer. Beyond breast cancer, little is known regarding the prognostic significance of mammographic features. MethodsWe evaluated relationships between nondense (fatty) breast area and dense area with all-cause mortality in 4,245 initially healthy women from the Breast Cancer Detection Demonstration...

Progestin effects on cell proliferation pathways in the postmenopausal mammary gland

Introduction Menopausal hormone therapies vary widely in their effects on breast cancer risk, and the mechanisms underlying these differences are unclear. The primary goals of this study were to characterize the mammary gland transcriptional profile of estrogen + progestin therapy in comparison with estrogen-alone or tibolone and investigate pathways of cell proliferation in a...

Abdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndrome

Background Abdominal aortic calcifications (AAC) predict cardiovascular mortality. A new scoring model for AAC, the Morphological Atherosclerotic Calcification Distribution (MACD) index may contribute with additional information to the commonly used Aortic Calcification Severity (AC24) score, when predicting death from cardiovascular disease (CVD). In this study we investigated...

Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys

Endogenous estrogens are important determinants of breast cancer risk in postmenopausal women. In this study we evaluated the effects of dietary soy isoflavonoids on endogenous estrogen metabolism in a postmenopausal primate model. Ovariectomized female cynomolgus monkeys were randomized to receive one of three diets for 36 months: (i) isoflavonoid-depleted soy protein isolate...

Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes

Background Proteolytic degradation of Type I Collagen by proteases may play an important role in remodeling of atherosclerotic plaques, contributing to increased risk of plaque rupture. The aim of the current study was to investigate whether human macrophage foam cells degrade the extracellular matrix (ECM) of atherosclerotic plaques by cathepsin K mediated processes. Methods We...

Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study

Background Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D). Methods Serum MCP-1 concentration, urine...

Transcriptomic profiles of aging in purified human immune cells

Fu Liu Craig Johnson R Graham Barr Thomas C Register Kathleen M Donohue Monica V Talor Daniela Cihakova Charles Gu Jasmin Divers David Siscovick Gregory Burke 0 Wendy Post Steven Shea David R Jacobs Jr

Methylomics of gene expression in human monocytes

DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of gene expression; however, the extent to which methylation of CpG dinucleotides correlates with gene expression at the genome-wide level is still largely unknown. Using purified primary monocytes from subjects in a large community-based cohort (n = 1264), we characterized methylation (>485...

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

 Carl D. Langefeld,3 Donald W. Bowden,1,2,4 Thomas C. Register,5 Yongmei Liu,3 Barry I. Freedman,4 J. Jeffrey Carr,3,6 Catherine C. Hedrick,7 and Stephen S. Rich3,7,8 1Department of Biochemistry, Wake

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

 Carl D. Langefeld,3 Donald W. Bowden,1,2,4 Thomas C. Register,5 Yongmei Liu,3 Barry I. Freedman,4 J. Jeffrey Carr,3,6 Catherine C. Hedrick,7 and Stephen S. Rich3,7,8 1Department of Biochemistry, Wake