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Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

assistance. Furthermore, Jakob Morgenstern and Thomas Fleming were supported by SFB 1118. We acknowledge financial support by Deutsche Forschungsgemeinschaft within the funding programme Open Access Publishing

Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes

The determination of individual prostaglandins (PG) in humans is mainly performed in urine samples. The quantification of PGs in human plasma could improve the understanding of particular PG species under various physiological and pathological conditions. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a dehydrated downstream product of PGD2 and is of high interest due to its...

The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy

Background/aims Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear. Methods Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultivated C. elegans, respectively. In STZ-diabetic Wistar rats (diabetes duration of 24...

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice

Objective. Glyoxalase-1 is an enzyme detoxifying methylglyoxal (MG). MG is a potent precursor of advanced glycation endproducts which are regarded to be a key player in micro- and macrovascular damage. Yet, the role of Glo1 in atherosclerosis remains unclear. In this study, the effect of Glo1 on mouse metabolism and atherosclerosis is evaluated. Methods. Glo1 knockdown mice were...

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice

Objective. Glyoxalase-1 is an enzyme detoxifying methylglyoxal (MG). MG is a potent precursor of advanced glycation endproducts which are regarded to be a key player in micro- and macrovascular damage. Yet, the role of Glo1 in atherosclerosis remains unclear. In this study, the effect of Glo1 on mouse metabolism and atherosclerosis is evaluated. Methods. Glo1 knockdown mice were...

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

Background An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function...

Methylglyoxal concentrations differ in standard and washed neonatal packed red blood cells

• PubMed • Google ScholarSearch for Thomas Fleming in:Nature Research journals • PubMed • Google ScholarSearch for George J. Eckert in:Nature Research journals • PubMed • Google ScholarSearch for Brenda B

Methylglyoxal Evokes Pain by Stimulating TRPA1

blinded to the treatment. Drugs and chemicals The glyoxalase 1 inhibitor Sr-p-Bromobenzylglutathione cyclopentyl diester was provided by Dr. Thomas Fleming and was prepared and characterized as previously

Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study

Introduction The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context of the sepsis syndrome. The aims of this study were to assess the impact of MG formation in different inflammatory settings and to evaluate its use for early diagnosis as well as prognosis of the sepsis syndrome. Methods In total, 120 patients in three groups...

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of glyoxalase 1 is linked to tumour multidrug resistance in cancer chemotherapy. We report herein that glycation of DNA by glyoxal and...

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects...

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

RuokojärviUniversity of Leeds, UKMark Gilthorpe, Sarah Fleming, Thomas Fleming & Yu-Kang TuLund University, SwedenBo Jonsson & Thomas LundhNational Taiwan University, Taipei, TaiwanWei J. Chen, Wen-Chung Lee, Chuhsing ... Kogevinas, Euripides G. Stephanou, Antonis Myridakis, Lucia Fazzo, Marco De Santis, Pietro Comba, Hannu Kiviranta, Panu Rantakokko, Riikka Airaksinen, Päivi Ruokojärvi, Mark Gilthorpe, Sarah Fleming, Thomas

C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction

Andreas Schlotterer Georgi Kukudov Farastuk Bozorgmehr Harald Hutter Xueliang Du Dimitrios Oikonomou Youssef Ibrahim Friederike Pfisterer Naila Rabbani Paul Thornalley Ahmed Sayed Thomas Fleming Per

Safety and Tolerability of BufferGel, a Novel Vaginal Microbicide, in Women in the United States

BufferGel (ReProtect, LLC) is a vaginal gel with an acidic buffering action that was designed to prevent vaginal neutralization by semen. The purpose of this study was to evaluate the safety and tolerability of BufferGel (ReProtect, Limited Liability Company) applied vaginally either once or twice daily by 27 women who were at low risk for acquisition of human immunodeficiency...

Impact of Human Immunodeficiency Virus Type 1 (HIV-1) Subtype on Women Receiving Single-Dose Nevirapine Prophylaxis to Prevent HIV-1 Vertical Transmission (HIV Network for Prevention Trials 012 Study)

In Uganda, the HIV Network for Prevention Trials (HIVNET) 012 study recently demonstrated that single-dose nevirapine (Nvp) prophylaxis is effective for preventing mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1). This exploratory study examines the relationship between HIV-1 subtype, MTCT, and the development of Nvp resistance (NvpR) in women...

DIABETES CLINICAL

Introduction and Aims: Diabetes mellitus type-2 (T2DM) is a metabolic disorder leading to diabetic nephropathy (DN) responsible for approximately 35% chronic renal failure (CRF) on waiting list of renal transplantation (RT). RT is a well accepted therapy for these patients however life-long immunosuppression mandatory to prevent the allograft rejection exposes them to high risk...