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Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface

and Daniel L. McElroy researched the data and edited the paper, Andrew T. Magis researched the data and wrote the paper, Thomas Osterbye researched the data and reviewed/edited the paper, Mark A ... Osterbye,1 Mark A. Atkinson,2 Kate M. Bailey,2 Amanda L. Posgai,2 and David A. Ostrov2 1Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark 2Department of Pathology, Immunology and Laboratory

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface

and Daniel L. McElroy researched the data and edited the paper, Andrew T. Magis researched the data and wrote the paper, Thomas Osterbye researched the data and reviewed/edited the paper, Mark A ... Osterbye,1 Mark A. Atkinson,2 Kate M. Bailey,2 Amanda L. Posgai,2 and David A. Ostrov2 1Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark 2Department of Pathology, Immunology and Laboratory

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface

and Daniel L. McElroy researched the data and edited the paper, Andrew T. Magis researched the data and wrote the paper, Thomas Osterbye researched the data and reviewed/edited the paper, Mark A ... Osterbye,1 Mark A. Atkinson,2 Kate M. Bailey,2 Amanda L. Posgai,2 and David A. Ostrov2 1Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark 2Department of Pathology, Immunology and Laboratory

Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans

Background The glycosphingolipid sulfatide has previously been found in several mammalian tissues, but information on the uptake of exogenously administered sulfatide in different organs in vivo is limited. In pancreatic beta cells, sulfatide has been shown to be involved in insulin processing and secretion in vitro. In this study, we examined the uptake of exogenously...

Alcohol Facilitates CD1d Loading, Subsequent Activation of NKT Cells, and Reduces the Incidence of Diabetes in NOD Mice

Incidence of Diabetes in NOD Mice Karsten Buschard Axel Kornerup Hansen Karen Jensen Dicky J. Lindenbergh-Kortleve Lilian F. de Ruiter Thomas C. Krohn Majbritt R. Hufeldt Finn K. Vogensen Bent Aasted Thomas ... Osterbye Bart O. Roep Colin de Haar Edward E. Nieuwenhuis Kathrin Maedler, University of Bremen, Germany Background: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility

Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization

Sulfatide is a glycolipid that has been associated with insulin-dependent diabetes mellitus. It is present in the islets of Langerhans and follows the same intracellular route as insulin. However, the role of sulfatide in the beta cell has been unclear. Here we present evidence suggesting that sulfatide promotes the folding of reduced proinsulin, indicating that sulfatide...

The glycosphingolipid sulfatide in the islets of Langerhans in rat pancreas is processed through recycling: possible involvement in insulin trafficking

In previous studies we have shown that sulfatide (galactosylceramide-3-O-sulfate), in various species, is present in the insulin-producing cells in pancreatic islets of Langerhans. In this study the synthesis of sulfatide in the islets has been investigated by pulse chase labeling at varying glucose levels and in the presence or absence of the glycosphingolipid synthesis...