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Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we identify USP19 as a negative regulator of TLR3/4-mediated signaling. USP19 deficiency increases the production of type I interferons (IFN) and proinflammatory cytokines induced by poly(I:C) or LPS...

Comparative study of sacroiliac screw placement guided by 3D-printed template technology and X-ray fluoroscopy

applications. KeywordsThree-dimensional printing Template Sacroiliac screw Fluoroscopy  Wu Zhou and Tian Xia contributed to the work equally and should be regarded as co-first authors. Introduction

Photocatalytic Degradation of 2,4-Dichlorophenol by TiO2 Intercalated Talc Nanocomposite

Novel nanocomposites have been prepared by intercalating TiO2 nanoparticles into talc. The nanocomposites have been verified by X-ray diffraction (XRD) from the appearance of a characteristic diffraction peak of TiO2. Thermal behavior of the prepared samples is examined by thermogravimetric analyzer (TGA), scanning electron microscope (SEM), and energy dispersive spectrometer...

Interaction between buyer power in agricultural procurement and seller power in food retailing, and optimal allocation of anti-trust efforts

In order to take appropriate and effective actions against anticompetitive behaviors in the agricultural sector, it is essential to understand the interaction between buyer power in agricultural procurement and seller power in food retailing and the optimal allocation of anti-trust efforts between markets to maximize welfare. This paper finds that, even if the policy objective is...

Local Influence Analysis for Quasi-Likelihood Nonlinear Models with Random Effects

Copyright © 2018 Tian Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Proper bile duct flow, rather than radical excision, is the most critical factor determining treatment outcomes of bile duct cysts

-Tian Xia†1Email author, Tao Yang†1, Yang Liu1, Bin Liang1, Jing Wang1 and Jia-Hong Dong1 †Contributed equally BMC Gastroenterology201818:129 https://doi.org/10.1186/s12876-018-0862-3 ©  The ... surgical approach for bile duct cyst patients, and should still be achieved whenever possible. Notes Hong-Tian Xia and Tao Yang contributed equally to this work. Abbreviations ALP:  alkaline

The biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and bioactivities toward immune cells

, 100049, Beijing, ChinaSijin Liu AuthorsSearch for Yu Qi in:Nature Research journals • PubMed • Google Scholar Search for Yun Liu in:Nature Research journals • PubMed • Google Scholar Search for Tian Xia

Theory and development of biplanar active shim coils for a permanent NMR analyzer

) Author Contributions Data curation: Tian Xia. 16 / 17 Investigation: Tian Xia, Zhiying Miao, Shanshan Chen, Hongzhi Wang. Methodology: Tian Xia. Writing ± original draft: Tian Xia. Writing ± review

Relationship between fine particulate matter, weather condition and daily non-accidental mortality in Shanghai, China: A Bayesian approach

. Author Contributions Data curation: Xin Fang, Bo Fang. Formal analysis: Xin Fang, Bo Fang. Funding acquisition: Yang Cao. Conceptualization: Chunfang Wang, Tian Xia, Matteo Bottai, Fang Fang, Yang Cao ... . Methodology: Matteo Bottai, Fang Fang, Yang Cao. Project administration: Yang Cao. Resources: Bo Fang, Chunfang Wang, Tian Xia, Yang Cao. Software: Yang Cao. Supervision: Chunfang Wang, Tian Xia, Matteo

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Selective targeting plus optimal biocompatibility is still a big challenge in nanomedicine. Although many nanomaterials including graphene oxide (GO) and molybdenum disulfide (MoS2) have been tested for this purpose, these materials possess both favorable features and drawbacks, which hampers their further development. Herein, we prepared MoS2/GO nanocomposites that manifested...

Catastrophic failure of nacre under pure shear stresses of torsion

for Christopher Hale-Sills in:Nature Research journals • PubMed • Google Scholar Search for Floyd Vilmont in:Nature Research journals • PubMed • Google Scholar Search for Tian Xia in:Nature Research

KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer

Single nucleotide polymorphisms (SNPs) in tumor-related genes have been reported to play important roles in cancer development. Recent studies have shown that 3’-untranslated regions (UTR) polymorphisms are associated with the occurrence and prognosis of cancers. The aim of this study is to analyze the association between KRAS and VEGF gene 3’-UTR SNPs and genetic susceptibility...

Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East

interest. Authors’ Contributions Zhaoshen Li, Chang Sun, and Zhuan Liao participated in the conception and design of the study. Muyun Liu, Chang Sun, Tian Xia, Di Zhang, and Lianghao Hu participated in the ... generation, collection, assembly, analysis, and/or interpretation of data. Muyun Liu, Zhuan Liao, Chang Sun, and Zhaoshen Li participated in the drafting or revision of the manuscript. Muyun Liu, Tian Xia

Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East

interest. Authors’ Contributions Zhaoshen Li, Chang Sun, and Zhuan Liao participated in the conception and design of the study. Muyun Liu, Chang Sun, Tian Xia, Di Zhang, and Lianghao Hu participated in the ... generation, collection, assembly, analysis, and/or interpretation of data. Muyun Liu, Zhuan Liao, Chang Sun, and Zhaoshen Li participated in the drafting or revision of the manuscript. Muyun Liu, Tian Xia

Genetic Background and Clinical Characters of Pediatric Chronic Pancreatitis: Data and Implications from the East

interest. Authors’ Contributions Zhaoshen Li, Chang Sun, and Zhuan Liao participated in the conception and design of the study. Muyun Liu, Chang Sun, Tian Xia, Di Zhang, and Lianghao Hu participated in the ... generation, collection, assembly, analysis, and/or interpretation of data. Muyun Liu, Zhuan Liao, Chang Sun, and Zhaoshen Li participated in the drafting or revision of the manuscript. Muyun Liu, Tian Xia

Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness

© 2016 Tian Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... drug delivery system. Competing Interests The authors declare that they have no competing interests. Authors’ Contributions Tian Xia and Weiju Hao equally contributed to this work. Acknowledgments

Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness

© 2016 Tian Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... drug delivery system. Competing Interests The authors declare that they have no competing interests. Authors’ Contributions Tian Xia and Weiju Hao equally contributed to this work. Acknowledgments

Integrated nano-opto-electro-mechanical sensor for spectrometry and nanometrology

W. van der Heijden, Maurangelo Petruzzella, Francesco Pagliano, Tian Xia, Michele Cotrufo, YongJin Cho, Frank W. M. van Otten & Andrea FioreCenter for Nanophotonics, FOM Institute AMOLF, Science Park ... for Tian Xia in:Nature Research journals • PubMed • Google Scholar Search for Leonardo Midolo in:Nature Research journals • PubMed • Google Scholar Search for Michele Cotrufo in:Nature Research

Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation

The wide application of engineered nanoparticles has induced increasing exposure to humans and environment, which led to substantial concerns on their biosafety. Some metal oxides (MOx) have shown severe toxicity in cells and animals, thus safe designs of MOx with reduced hazard potential are desired. Currently, there is a lack of a simple yet effective safe design approach for...