Advanced search    

Search: authors:"Timothy Chevassut"

4 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

TET2 Inhibits Differentiation of Embryonic Stem Cells but Does Not Overcome Methylation-Induced Gene Silencing

TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5′-methylcytosine to 5′-hydroxymethylcytosine within DNA and has been implicated in the process of genomic demethylation. However, the mechanism by which TET2 loss of function results in hematopoietic...

The Role of miRNA in Haematological Malignancy

31 July 2013; Accepted 1 October 2013 Academic Editor: Guido Kobbe Copyright © 2013 Stephanie Gounaris-Shannon and Timothy Chevassut. This is an open access article distributed under the Creative

The Epigenetic Landscape of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a genetically heterogeneous disease. Certain cytogenetic and molecular genetic mutations are recognized to have an impact on prognosis, leading to their inclusion in some prognostic stratification systems. Recently, the advent of high-throughput whole genome or exome sequencing has led to the identification of several novel recurrent mutations in...

The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells

• PubMed • Google ScholarSearch for Bruce Cooper in:Nature Research journals • PubMed • Google ScholarSearch for Timothy Chevassut in:Nature Research journals • PubMed • Google ScholarSearch for Amy C