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Treatment and survival of osteosarcoma and Ewing sarcoma of the skull: a SEER database analysis

BackgroundCommon primary bone tumors include osteosarcomas (OSC) and Ewing sarcomas (EWS). The skull is a rare site, and literature about their treatment and survival is scarce. Using the Surveillance, Epidemiology, and End Results (SEER) database, this study aims to assess the treatment and survival of skull OSC and skull EWS, as well as predictors for survival.MethodsSkull OSC...

Randomized controlled trials comparing surgery to non-operative management in neurosurgery: a systematic review

 Systematic review Trial quality  Timothy R. Smith and Marike L. D. Broekman contributed equally to this work. This article is part of the Topical Collection on Neurosurgery general Electronic supplementary

Ethical considerations of neuro-oncology trial design in the era of precision medicine

The field of oncology is currently undergoing a paradigm shift. Advances in the understanding of tumor biology and in tumor sequencing technology have contributed to the shift towards precision medicine, the therapeutic framework of targeting the individual oncogenic changes each tumor harbors. The success of precision medicine therapies, such as targeted kinase inhibitors and...

Defensive medicine among neurosurgeons in the Netherlands: a national survey

ObjectiveIn defensive medicine, practice is motivated by legal rather than medical reasons. Previous studies have analyzed the correlation between perceived medico-legal risk and defensive behavior among neurosurgeons in the United States, Canada, and South Africa, but not yet in Europe. The aim of this study is to explore perceived liability burdens and self-reported defensive...

Venous thromboembolism and intracranial hemorrhage after craniotomy for primary malignant brain tumors: a National Surgical Quality Improvement Program analysis

?; Primary malignant brain tumor?; Pulmonary embolism?; Venous thromboembolism - Timothy R. Smith and Marike L. D. Broekman have shared last author. Introduction Venous thromboembolism (VTE), including

The endoscopic endonasal approach is not superior to the microscopic transcranial approach for anterior skull base meningiomas—a meta-analysis

Object In the past decade, the endonasal transsphenoidal approach (eTSA) has become an alternative to the microsurgical transcranial approach (mTCA) for tuberculum sellae meningiomas (TSMs) and olfactory groove meningiomas (OGMs). The aim of this meta-analysis was to evaluate which approach offered the best surgical outcomes. Methods A systematic review of the literature from...

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal

A single-chain Fv fragment antibody (scFv) specific for the plant hormone abscisic acid (ABA) has been expressed in the bacterium Escherichia coli as a fusion protein. The kinetics of ABA binding have been measured using surface plasmon resonance spectrometry (BIAcore 2000) using surface and solution assays. Care was taken to calculate the concentration of active protein in each...

Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results

BackgroundFluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma.MethodsWe...

Health-related quality of life of cranial WHO grade I meningioma patients: are current questionnaires relevant?

Background The clinical relevance of Health-Related Quality of Life (HRQoL) in meningioma patients has been increasingly acknowledged in recent years. Various questionnaires have been used. However, almost none of these questionnaires has been particularly developed for and/or validated in this patient group. Therefore, the aim of this study was to assess the relevance and...

Malpractice Liability and Defensive Medicine: A National Survey of Neurosurgeons

Background Concern over rising healthcare expenditures has led to increased scrutiny of medical practices. As medical liability and malpractice risk rise to crisis levels, the medical-legal environment has contributed to the practice of defensive medicine as practitioners attempt to mitigate liability risk. High-risk specialties, such as neurosurgery, are particularly affected...

NEUROSURGICAL TREATMENTS

, Joseph G. Adel, Timothy R. Smith , and James P. Chandler; Northwestern University , Chicago, IL , USA 4 Department of Pathology, Beijing Sanbo Brain Hospital, Capital Medical University , Beijing , China