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Search: authors:"Timothy W. Synold"

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Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

PurposePyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin polyamides with demonstrated activity against androgen receptor signaling in cell...