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The structural integrity exerted by N‐terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens

Onconase, a cytotoxic ribonuclease from Rana pipiens, possesses pyroglutamate (Pyr) at the N‐terminus and has a substrate preference for uridine–guanine (UG). To identify residues responsible for onconase’s cytotoxicity, we cloned the rpr gene from genomic DNA and expressed it in Escherichia coli BL21(DE3). The recombinant onconase with Met at the N‐terminus had reduced...

BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules

Cardiac tubular-like membrane invaginations contain the membrane scaffolding protein BIN1, which tethers dynamic microtubules that deliver calcium channels directly to T-tubule membrane.

Bacterial Vaginosis Associated with Increased Risk of Female-to-Male HIV-1 Transmission: A Prospective Cohort Analysis among African Couples

. Baeten Musa O. Ngayo Carol A. Spiegel Ting Hong Deborah Donnell Connie Celum Saidi Kapiga Sinead Delany Elizabeth A. Bukusi Heather Watts, NICHD, United States of America Background: Bacterial vaginosis

An Intelligent Control Hydropower System Based on Multi-Agent Theory

Data Science Journal AN INTELLIGENT CONTROL HYDROPOWER SYSTEM BASED ON MULTI-AGENT THEORY Ting-hong Zhao Xue-yi Qi Zi-bin Man 0 0 School of Computer and Communication, LAN Zhou University of

Ranking Candidate Disease Genes from Gene Expression and Protein Interaction: A Katz-Centrality Based Approach

Many diseases have complex genetic causes, where a set of alleles can affect the propensity of getting the disease. The identification of such disease genes is important to understand the mechanistic and evolutionary aspects of pathogenesis, improve diagnosis and treatment of the disease, and aid in drug discovery. Current genetic studies typically identify chromosomal regions...

Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart

Background Heart failure due to diastolic dysfunction exacts a major economic, morbidity and mortality burden in the United States. Therapeutic agents to improve diastolic dysfunction are limited. It was recently found that Dynamin related protein 1 (Drp1) mediates mitochondrial fission during ischemia/reperfusion (I/R) injury, whereas inhibition of Drp1 decreases myocardial...

Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis

Background Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating network resulting from the dysfunctions of multiple genes or their products. Therefore, network based systems approach can be helpful for the identification of candidate genes related to complex diseases and their relationships. Axial spondyloarthropathy...

Correlation analysis of gene polymorphisms and β-lactam allergy

ZHANG, Qian LIU, Jun WANG, Ze-jing LIU, and Ting-hong LV declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee

Identification of plant vacuolar transporters mediating phosphate storage

2, Taipei 11529, TaiwanTzu-Yin Liu, Teng-Kuei Huang, Shu-Yi Yang, Yu-Ting Hong, Su-Fen Chiang, Wen-Chien Lu & Tzyy-Jen ChiouMolecular and Biological Agricultural Sciences Program, Taiwan International ... ScholarSearch for Teng-Kuei Huang in:Nature Research journals • PubMed • Google ScholarSearch for Shu-Yi Yang in:Nature Research journals • PubMed • Google ScholarSearch for Yu-Ting Hong in:Nature Research

Benzothiazinethione is a potent preclinical candidate for the treatment of drug-resistant tuberculosis

New chemotherapeutic compounds are needed to combat multidrug-resistant Mycobacterium tuberculosis (Mtb), which remains a serious public-health challenge. Decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1 enzyme) has been characterized as an attractive therapeutic target to address this urgent demand. Herein, we have identified a new class of DprE1 inhibitors...

A Study of Coal Miners’ Safety Psychological Elements Based on Questionnaire Survey

During the production process, the instability of safety psychological elements of coal miners contributes to unsafe behaviors that may result in fatal accident. To search the dominant psychological elements, three types of unsafe psychology, comprising 18 unsafe psychological elements, are obtained by theoretical analysis and site survey. Then, an assessment model is established...

Integrating hypertension screening at the time of voluntary HIV testing among adults in South Africa

study, the clinical sites for sharing their space, and our research staff and nurses who conducted the study. Author Contributions Conceptualization: Paul K. Drain. Data curation: Ting Hong, Meighan ... Krows, Sabina Govere, Connie Celum. Formal analysis: Paul K. Drain, Ting Hong, Anjum Hajat. Funding acquisition: Paul K. Drain, Hilary Thulare, Mahomed Yunus S. Moosa, Connie Celum. Investigation: Paul