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Search: authors:"Ting-Hong Yang"

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Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis

Background Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating network resulting from the dysfunctions of multiple genes or their products. Therefore, network based systems approach can be helpful for the identification of candidate genes related to complex diseases and their relationships. Axial spondyloarthropathy...

Ranking Candidate Disease Genes from Gene Expression and Protein Interaction: A Katz-Centrality Based Approach

Many diseases have complex genetic causes, where a set of alleles can affect the propensity of getting the disease. The identification of such disease genes is important to understand the mechanistic and evolutionary aspects of pathogenesis, improve diagnosis and treatment of the disease, and aid in drug discovery. Current genetic studies typically identify chromosomal regions...