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Developmental Patterns of Cognitive Function and Associated Factors among the Elderly in Taiwan

Previous research has discussed the factors associated with cognitive impairment, but the patterns of its development have been little described. Our aim was to examine long-term development of cognitive function and the related factors using longitudinal follow-up data. A group-based trajectory model and multinomial logistic regression were applied to identify trajectories and...

NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation

POU-homeodomain transcription factor POU3F2 is a critical transcription factor that participates in neuronal differentiation. However, little is known about its downstream mediators. Here genome-wide analyses of a human neuronal differentiation cell model, NT2D1, suggested neurotrophin-3 (NTF3), a key mediator of neuronal development during the early neurogenic period, as a...

Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women

in this study. Author Contributions Conceptualization: Hung-Ming Wu. Formal analysis: Chew-Teng Kor, Hung-Ming Wu. Funding acquisition: Hung-Ming Wu. Investigation: I-Lun Hsin, Ting-Yu Chen

Effect of psycho-educational interventions on quality of life in patients with implantable cardioverter defibrillators: a meta-analysis of randomized controlled trials

Background Implantable cardioverter defibrillators (ICD) were developed for primary and secondary prevention of sudden cardiac death. However, ICD recipients’ mortality is significantly predicted by their quality of life (QOL). The aim of this meta-analysis was to evaluate the effects of psycho-educational interventions on QOL in patients with ICDs. Methods We systematically...

Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

Ting-Yu Chen 2 Hung-Ming Wu 2 0 Department of Nephrology, Changhua Christian Hospital , Changhua, Taiwan , 3 Comprehensive Breast Cancer Center, Changhua Christian Hospital , Changhua, Taiwan , 4

Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

Introduction Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women. Participants and design This cross-sectional study...

NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and ?-catenin accumulation

Background Adrenogonadal cell growth and differentiation are controlled by nuclear receptor NR5A1 (Ad4BP/SF-1) that regulates the expression of adrenal and gonadal genes. In addition, SF-1 also resides in the centrosome and controls centrosome homeostasis by restricting the activity of centrosomal DNA-PK and CDK2/cyclin A. Results Here we show that SF-1 depletion resulted in...