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New data on the distribution, biology and ecology of the longhorn beetles from the area of South and East Kazakhstan (Coleoptera, Cerambycidae)

Lech Karpiński Radosław Plewa Jacek Hilszczański Marek Bidas TJ KŁ MW WTS Tomasz Jaworski Krzysztof Łoś Marcin Walczak Wojciech T. Szczepański The specimens are preserved in the entomological

Surrogate tree cavities: boxes with artificial substrate can serve as temporary habitat for Osmoderma barnabita (Motsch.) (Coleoptera, Cetoniinae)

Many saproxylic insects have declined or became extinct, mainly due to habitat loss and fragmentation, and their survival increasingly depends on active conservation. Efforts to achieve this goal may be supported by the introduction of new methods, including creation of artificial habitats. Here we present results of studies on the use of wooden boxes mimicking tree cavities for...

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology

Changes in the morphology of dendritic spines are prominent during learning and in different neurological and neuropsychiatric diseases, including those in which glycogen synthase kinase-3β (GSK-3β) has been implicated. Despite much evidence of the involvement of GSK-3β in functional synaptic plasticity, it is unclear how GSK-3β controls structural synaptic plasticity (i.e., the...

Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease

, 37073 Göttingen, Germany Received 18 May 2010; Accepted 9 July 2010 Academic Editor: Gemma Casadesus Copyright © 2010 Tomasz Jaworski et al. This is an open access article distributed under the

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

Background GSK3β is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar disorder to Alzheimer’s disease (AD). In contrast, the GSK3α isozyme remained largely ignored with respect to both aspects. Results We generated and characterized two mouse strains with neuron-specific or with total GSK3...

Tauopathy Differentially Affects Cell Adhesion Molecules in Mouse Brain: Early Down-Regulation of Nectin-3 in Stratum Lacunosum Moleculare

Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain remain to be elucidated. Here, we investigated selected cell adhesion molecules for alterations in expression levels and neuronal...

Degradation and beyond: Control of androgen receptor activity by the proteasome system


Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy

The stratum lacunosum moleculare (SLM) is the connection hub between entorhinal cortex and hippocampus, two brain regions that are most vulnerable in Alzheimer’s disease. We recently identified a specific synaptic deficit of Nectin-3 in transgenic models for tauopathy. Here we defined cognitive impairment and electrophysiological problems in the SLM of Tau.P301L mice, which...

Profoundly diminished gastric mucus production during Naprosyn administration as a potential factor contributing to mucosal injury

0 PROFOUNDLY DIMINISHED GASTRIC MUCUS PRODUCTION DURING NAPROSYN ADMINISTRATION AS A POTENTIAL FACTOR CONTRIBUTING TO MUCOSAL INJURY Tomasz Jaworski , M.D., Irene Sarosiek, M.D., Sandra Sostarich ... ADMINISTRATION: ITS POTENTIAL CLINICAL SIGNIFICANCE Tomasz Jaworski , M.D., Irene Sarosiek, M.D., Sandra Sostarich, R.N., Katherine Roeser, B.S., Mike Connor, M.D., Scott Brotze, M.D., Jerzy Sarosiek, M.D

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice

In Alzheimer's disease tauopathy is considered secondary to amyloid, and the duality obscures their relation and the definition of their respective contributions. Transgenic mouse models do not resolve this problem conclusively, i.e. the relative hierarchy of amyloid and tau pathology depends on the actual model and the genes expressed or inactivated. Here, we approached the...