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Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension

Nakagawa. Methodology: Kazufumi Nakamura, Kaoru Akazawa. Project administration: Kazufumi Nakamura, Hiroshi Ito. Resources: Kazufumi Nakamura. Visualization: Kazufumi Nakamura, Masashi Yoshida, Toru ... Miyoshi. Writing ? original draft: Kazufumi Nakamura. Writing ? review & editing: Kazufumi Nakamura. 10 / 11 1. Archer S , Rich S. Primary pulmonary hypertension: a vascular biology and translational

Protective effect of nicorandil on myocardial injury following percutaneous coronary intervention in older patients with stable coronary artery disease: Secondary analysis of a randomized, controlled trial (RINC)

. Project administration: Kunihisa Kohno, Hiroshi Ito. Writing ? original draft: Norifumi Kawakita. Writing ? review & editing: Toru Miyoshi, Hiroshi Ito. 12 / 14 13 / 14 1. Kizer J ( 2003 ) Role of ... for their technical assistance. We thank Ellen Knapp, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. 11 / 14 Author Contributions Conceptualization: Toru

Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

, Minoru Satoh, Megumi Kondo, Kazuhiro Osawa, Omer F. Hatipoglu, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita. Formal analysis: Kazufumi Nakamura, Yasushi Koyama, Minoru Satoh. Funding acquisition ... : Kazufumi Nakamura, Hiroshi Ito. Software: Yasushi Koyama. Visualization: Toru Miyoshi. Writing ± original draft: Kazufumi Nakamura. Writing ± review & editing: Kazufumi Nakamura. 12 / 14 10. 11. 12. 13

Diagnostic Performance of First-Pass Myocardial Perfusion Imaging without Stress with Computed Tomography (CT) Compared with Coronary CT Angiography Alone, with Fractional Flow Reserve as the Reference Standard

Coronary computed tomography angiography (CCTA) in combination with first-pass CT myocardial perfusion imaging (MPI) has a better diagnostic performance than CCTA alone, compared with invasive coronary angiography as the reference standard. The aim of this study was to investigate the additional diagnostic value of first-pass CT-MPI without stress for detecting hemodynamic...

Prognostic significance of endothelial dysfunction in patients undergoing percutaneous coronary intervention in the era of drug-eluting stents

Background Endothelial function is a prognostic predictor in patients undergoing percutaneous coronary intervention (PCI). However, in an era with widespread use of drug-eluting stents, the clinical relevance of endothelial dysfunction on restenosis in patients undergoing PCI has not been fully evaluated. Methods This study included 80 patients with stable angina pectoris. Flow...

Nonalcoholic Hepatic Steatosis Is a Strong Predictor of High-Risk Coronary-Artery Plaques as Determined by Multidetector CT

Background Nonalcoholic fatty liver disease is associated with a risk of coronary artery disease (e.g., diabetes mellitus, dyslipidemia, metabolic syndrome). We evaluated whether nonalcoholic hepatic steatosis is associated with high-risk plaques as assessed by multidetector computed tomography (CT). Methods This retrospective study involved 414 participants suspected of having...

Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

for assistance with statistical analysis. We also thank the 3D study investigators: Kazufumi Nakamura, MD; Toru Miyoshi, MD, Hiroshi Ito, MD (Okayama University, Okayama, Japan), Hajime Kihara, MD

A calcified amorphous tumor that developed on both sides of the atrioventricular valve annulus

carefully monitored by echocardiography. Compliance with ethical standards Conflict of interest Masaki Kinoshita, Hideki Okayama, Go Kawamura, Tatsuya Shigematsu, Tatsunori Takahashi, Toru Miyoshi, Akinori

Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study

Toru Miyoshi 0 Yoko Noda Hiroki Oe Norihisa Toh Kazufumi Nakamura Kunihisa Kohno Hiroshi Morita Hiroshi Ito 0 Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine

DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study

Kihara Kenei Shimada Shota Fukuda Kyoko Watanabe Tsutomu Takagi Kei Yunoki 0 Toru Miyoshi 0 Kumiko Hirata Junichi Yoshikawa Hiroshi Ito 0 0 Department of Cardiovascular Medicine, Okayama University ... Osaka Foundation for the prevention of cancer and cardiovascular diseases. The authors also thank the EDGE study investigators: Kazufumi Nakamura, MD; Hiroki Oe, MD; Kei Yunoki, MD; Toru Miyoshi, MD

Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

Background Heart failure with left ventricular (LV) hypertrophy is often associated with insulin resistance and inflammation. Recent studies have shown that dipeptidyl peptidase 4 (DPP4) inhibitors improve glucose metabolism and inflammatory status. We therefore evaluated whether vildagliptin, a DPP4 inhibitor, prevents LV hypertrophy and improves diastolic function in...

Differential association of visceral adipose tissue with coronary plaque characteristics in patients with and without diabetes mellitus

Background Excess visceral adipose tissue (VAT) is closely associated with the presence of coronary artery plaques that are vulnerable to rupture. Patients with diabetes mellitus (DM) have more VAT than patients without DM, but the extent to which VAT contributes to the characteristics of coronary plaques before and after the development of DM is not fully understood. Methods We...

Alogliptin ameliorates postprandial lipemia and postprandial endothelial dysfunction in non- diabetic subjects: a preliminary report

Background Postprandial hyperlipidemia impairs endothelial function and participates in the development of atherosclerosis. We investigated the postprandial effects of a dipeptidyl peptidase IV inhibitor, alogliptin, on endothelial dysfunction and the lipid profile. Methods A randomized cross-over trial design in 10 healthy volunteers (8 males and 2 females, 35 ± 10 years) was...

Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E-deficient (apoE−/−) mice. Soat1, encoding sterol o-acyltransferase 1, is a functional candidate gene located underneath the...

Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

Background Adipocyte fatty acid-binding protein (A-FABP) has been reported to play critical roles in the development of atherosclerosis. We investigated whether an increased in plasma A-FABP level can be independently associated with the presence of coronary artery disease (CAD). Methods Two hundred eleven consecutive male patients (mean age: 66 years, range: 33-87 years) were...

Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris

Background Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involved in renal function in patients with stable angina pectoris. Methods A total of 221 patients with significant coronary artery stenosis were enrolled after...

Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanMutsumi Iwamoto, Satoshi Hirohata, Hiroko Ogawa, Takashi Ohtsuki, Toru Miyoshi, Faruk O Hatipoglu & Yoshifumi ... journals • PubMed • Google ScholarSearch for Ryoko Shinohata in:Nature Research journals • PubMed • Google ScholarSearch for Toru Miyoshi in:Nature Research journals • PubMed • Google ScholarSearch for Faruk

Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation

B-type natriuretic peptide (BNP) levels have been shown to be elevated in patients with paroxysmal atrial fibrillation (PAF); however, the underlying mechanisms have not been fully elucidated. Earlier, we reported that an increase in the augmentation index (AI), which is an index of wave reflection and arterial stiffness, is associated with PAF. In this study, we investigate the...

Hyaluronan receptors involved in cytokine induction in monocytes

During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular response and molecular mechanism of hyaluronan–hyaluronan receptor interactions in mononuclear cells are not well understood. The...

Circulating KCNH2 Current-Activating Factor in Patients with Heart Failure and Ventricular Tachyarrhythmia

Background It is estimated that approximately half of the deaths in patients with HF are sudden and that the most likely causes of sudden death are lethal ventricular tachyarrhythmias such as ventricular tachycardia (VT) or fibrillation (VF). However, the precise mechanism of ventricular tachyarrhythmias remains unknown. The KCNH2 channel conducting the delayed rectifier K...