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Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification

Kazunori Kajino Toshiyuki Kobayashi Mitsue Saito Masahiko Tanabe Saiko Kazuno Yoshiki Miura Kaoru Mogushi OPEN Published: xx xx xxxx One-step nucleic acid amplification (OSNA) is an established method for

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

Irinotecan (CPT-11) is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Recent studies with cell lines show that CES2 expression is regulated by the tumor suppressor protein p53. However, clinical evidence for this regulatory mechanism in cancer is lacking. In...

Considering Patients’ Mental Capacity When Giving Them Bad News May Help Their Well-Being: A Case of Suicide Attempt after Being Informed of Lung Cancer Diagnosis

-0053, Japan Received 6 February 2014; Revised 8 May 2014; Accepted 13 May 2014; Published 21 May 2014 Academic Editor: Liliana Dell’Osso Copyright © 2014 Toshiyuki Kobayashi et al. This is an open

Effectiveness of Electroconvulsive Therapy for Depression and Cotard’s Syndrome in a Patient with Frontotemporal Lobe Dementia

Copyright © 2012 Toshiyuki Kobayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

TSC1 Controls Distribution of Actin Fibers through Its Effect on Function of Rho Family of Small GTPases and Regulates Cell Migration and Polarity

The tumor-suppressor genes TSC1 and TSC2 are mutated in tuberous sclerosis, an autosomal dominant multisystem disorder. The gene products of TSC1 and TSC2 form a protein complex that inhibits the signaling of the mammalian target of rapamycin complex1 (mTORC1) pathway. mTORC1 is a crucial molecule in the regulation of cell growth, proliferation and survival. When the TSC1/TSC2...

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

• Google ScholarSearch for Katsunori Iwasaki in:Nature Research journals • PubMed • Google ScholarSearch for Toshiyuki Kobayashi in:Nature Research journals • PubMed • Google ScholarSearch for Okio Hino

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

• Google ScholarSearch for Toshiyuki Kobayashi in:Nature Research journals • PubMed • Google ScholarSearch for Yukio Takamatsu in:Nature Research journals • PubMed • Google ScholarSearch for Okio Hino

On the establishment of the Takagi Lectures

Toshiyuki Kobayashi 0 0 Lecture Hall (Room No. 420), Research Institute for Mathematical Sciences, Kyoto University , Kyoto, Japan The Takagi Lectures are the first series of lectures in mathematics

Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system

Hereditary renal carcinomas in the Eker rat are caused by germline retrotransposon insertion in the tuberous sclerosis-2 (Tsc2) gene. We established previously a transgenic Eker rat model into which was introduced a wild-type Tsc2 gene. The embryonic lethality of mutant homozygotes and renal carcinogenesis of heterozygotes were completely suppressed by this transgene (Tg). The...