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7 papers found.
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Neonatal Treatment With Beta-Cell Stimulatory Agents Reduces the Incidence of Diabetes in BB Rats

The aim of the study was to investigate whether various beta-cell stimulatory drugs, given neonatally, influence the incidence of diabetes in BB rats. Newborn BB rats were treated twice daily for 6 days and diabetes development was observed during the following 200-day study period. Compared to a diabetes incidence of 63.8% in 163 control BB rats which received saline or were...

Neonatal Treatment With Beta-Cell Stimulatory Agents Reduces the Incidence of Diabetes in BB Rats

The aim of the study was to investigate whether various beta-cell stimulatory drugs, given neonatally, influence the incidence of diabetes in BB rats. Newborn BB rats were treated twice daily for 6 days and diabetes development was observed during the following 200-day study period. Compared to a diabetes incidence of 63.8% in 163 control BB rats which received saline or were...

Genetic Background Determines the Size and Structure of the Endocrine Pancreas

Troels Bock Bente Pakkenberg Karsten Buschard Key parameters of the endocrine pancreas, such as islet number, islet mass, -cell mass, and -cell mass, were studied in different strains of inbred

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

Troels Bock Bente Pakkenberg Karsten Buschard It is important for our understanding of the pancreatic islets to study whether new islets are able to form in the intact pancreas. We developed a new

Growth and Functional Maturation of β-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas

The development of islet cell transplantation as a cure for diabetes is limited by the shortage of human donor organs. Moreover, currently used grafts exhibit a marginal β-cell mass with an apparently low capacity for β-cell renewal and growth. Although duct-associated nonendocrine cells have often been suggested as a potential source for β-cell production, recent work in mice...

Linear Correlation Between the Total Islet Mass and the Volume-Weighted Mean Islet Volume

Maren Skau Bente Pakkenberg Karsten Buschard Troels Bock To understand the dynamics of islet population, especially during conditions with growth of the total islet mass, it is important to have

Improved Glucose Tolerance and Acinar Dysmorphogenesis by Targeted Expression of Transcription Factor PDX-1 to the Exocrine Pancreas

The homeodomain protein PDX-1 is critical for pancreas development and is a key regulator of insulin gene expression. PDX-1 nullizygosity and haploinsufficiency in mice and humans results in pancreatic agenesis and diabetes, respectively. At embryonic day (e) 10.5, PDX-1 is expressed in all pluripotential gut-derived epithelial cells destined to differentiate into the exocrine...