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LncRNA AK023948 is a positive regulator of AKT

Center, Jackson, Mississippi 39216, USAPratirodh Koirala, Jianguo Huang, Tsui-Ting Ho, Xianfeng Ding & Yin-Yuan MoDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi ... ScholarSearch for Tsui-Ting Ho in:Nature Research journals • PubMed • Google ScholarSearch for Fangting Wu in:Nature Research journals • PubMed • Google ScholarSearch for Xianfeng Ding in:Nature Research journals

Regulation of PCGEM1 by p54/nrb in prostate cancer

, Hangzhou, ChinaXianfeng Ding AuthorsSearch for Tsui-Ting Ho in:Nature Research journals • PubMed • Google ScholarSearch for Jianguo Huang in:Nature Research journals • PubMed • Google ScholarSearch for

Linc-RoR promotes c-Myc expression through hnRNP I and AUF1

Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in humans and it has also been implicated in tumorigenesis. However, the underlying mechanism of Linc-RoR-mediated gene expression in cancer is poorly understood. The present study demonstrates that Linc-RoR plays an oncogenic role in part through regulation of c-Myc expression. Linc-RoR...

Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines

The CRISPR/Cas has been recently shown to be a powerful genome-editing tool in a variety of organisms. However, these studies are mainly focused on protein-coding genes. The present study aims to determine whether this technology can be applied to non-coding genes. One of the challenges for knockout of non-coding genes is that a small deletion or insertion generated by the...

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

Background Genome-wide transcriptome profiling generated by microarray and RNA-Seq often provides deregulated genes or pathways applicable only to larger cohort. On the other hand, individualized interpretation of transcriptomes is increasely pursued to improve diagnosis, prognosis, and patient treatment processes. Yet, robust and accurate methods based on a single paired-sample...

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

high throughput experiments that support off-label medication repositioning for individualized precision therapy. Notes Vincent Gardeux, Ahmet D Arslan, Ikbel Achour, Tsui-Ting Ho contributed equally