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Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica

Technology (DST), India for providing facility to conduct this study. Author Contributions Conceptualization: Tuhina Banerjee. Data curation: Aradhana Singh. Formal analysis: Aradhana Singh. Investigation ... : Aradhana Singh, Raju Kumar. Methodology: Aradhana Singh. Project administration: Tuhina Banerjee. Resources: Raju Kumar, Sunit Kumar Shukla. Supervision: Tuhina Banerjee, Sunit Kumar Shukla. Writing

High Prevalence and Endemicity of Multidrug Resistant Acinetobacter spp. in Intensive Care Unit of a Tertiary Care Hospital, Varanasi, India

Medical Sciences, Banaras Hindu University, Varanasi 221005, India Correspondence should be addressed to Tuhina Banerjee; moc.oohay@anihutrd Received 31 January 2018; Accepted 31 May 2018; Published 2 ... July 2018 Academic Editor: Nongnuch Vanittanakom Copyright © 2018 Tuhina Banerjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Prevalence of Virulence Factors and Drug Resistance in Clinical Isolates of Enterococci: A Study from North India

Sciences, Banaras Hindu University, Varanasi 221005, India Received 31 May 2015; Revised 6 August 2015; Accepted 9 August 2015 Academic Editor: Chiung-Yu Hung Copyright © 2015 Tuhina Banerjee and Shampa

Prevalence of Virulence Factors and Drug Resistance in Clinical Isolates of Enterococci: A Study from North India

Sciences, Banaras Hindu University, Varanasi 221005, India Received 31 May 2015; Revised 6 August 2015; Accepted 9 August 2015 Academic Editor: Chiung-Yu Hung Copyright © 2015 Tuhina Banerjee and Shampa

Rapid Screening of MDR-TB in Cases of Extra Pulmonary Tuberculosis Using Geno Type MTBDRplus

Background Drug resistance in tuberculosis is a major public health challenge in developing countries. The limited data available on drug resistance in extra pulmonary tuberculosis stimulated us to design our study on anti-tuberculosis drug resistance pattern in cases of extra pulmonary tuberculosis in a tertiary referral hospital of North India. We performed Geno Type MTBDRplus...

Substrate-Induced Unfolding of Protein Disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from Its Holotoxin

To generate a cytopathic effect, the catalytic A1 subunit of cholera toxin (CT) must be separated from the rest of the toxin. Protein disulfide isomerase (PDI) is thought to mediate CT disassembly by acting as a redox-driven chaperone that actively unfolds the CTA1 subunit. Here, we show that PDI itself unfolds upon contact with CTA1. The substrate-induced unfolding of PDI...

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Cholera toxin (CT) travels as an intact AB5 protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the...