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From the Editors: Can I trust your findings? Ruling out alternative explanations in international business research

issues, especially corruption in international business. He is an AIB Fellow and the chair of the International Management Division of the Academy of Management. Ulf Andersson (PhD Uppsala University

From the Editors: Explaining interaction effects within and across levels of analysis

Many manuscripts submitted to the Journal of International Business Studies propose an interaction effect in their models in an effort to explain the complexity and contingency of relationships across borders. In this article, we provide guidance on how best to explain the interaction effects theoretically within and across levels of analysis. First, in the case of interactions...

Regulation of HMGB1 release by inflammasomes

High mobility group box 1 (HMGB1) is an evolutionarily conserved non-histone chromatin-binding protein. During infection or injury, activated immune cells and damaged cells release HMGB1 into the extracellular space, where HMGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of inflammatory diseases. Recent studies reveal that...

From the Editors: How to write articles that are relevant to practice

Although the Journal of International Business Studies is not a practice-oriented journal, thinking deeper about the practical relevance of our articles can only help enrich them and help decision makers implement better decisions. However, while many academic articles in social sciences go to great lengths to explain their theoretical and empirical impact, in many cases their...

Subwavelength-Diameter Silica Wire and Photonic Crystal Waveguide Slow Light Coupling

Counter-directional coupling between subwavelength-diameter silica wire and single-line-defect two-dimensional photonic crystal slab waveguide is studied numerically using parallel three-dimensional finite-different time-domain method. By modifying silica wire properties or engineering photonic crystal waveguide dispersion band, the coupling central wavelength can be moved to the...

Subwavelength-Diameter Silica Wire and Photonic Crystal Waveguide Slow Light Coupling

Counter-directional coupling between subwavelength-diameter silica wire and single-line-defect two-dimensional photonic crystal slab waveguide is studied numerically using parallel three-dimensional finite-different time-domain method. By modifying silica wire properties or engineering photonic crystal waveguide dispersion band, the coupling central wavelength can be moved to the...

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

Introduction In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and IL-1β, through the formation of complexes. Extracellular HMGB1 is abundant in arthritic joint tissue where it is suggested to...

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. To function as an alarmin, HMGB1...

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis

High-mobility group chromosomal box protein 1 (HMGB1) is a structural nuclear protein that promotes inflammation when present extracellularly. Aberrant, extracellular HMGB1 expression has been demonstrated in human and experimental synovitis. The aim of the present study was to elucidate the temporal and spatial expression of HMGB1 compared to that of the central mediators tumor...

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

Introduction High-mobility group box chromosomal protein 1 (HMGB1) has recently been identified as an endogenous mediator of arthritis. TNF and IL-1β, pivotal cytokines in arthritis pathogenesis, both have the ability to induce the release of HMGB1 from myeloid and dendritic cells. It was, therefore, decided to investigate whether treatment based on TNF blockade in rheumatoid...

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

Introduction High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The protein is aberrantly expressed extracellularly in the settings of clinical and experimental synovitis. Therapy based on HMGB1 antagonists has shown encouraging results in experimental arthritis and warrants further...

Cognitive Correlates of Visual Speech Understanding in Hearing-Impaired Individuals

Ulla-Britt Persson for checking the lan- Behavioural Sciences, Linko ping University , S-581 83 Linko ping, Swe- den ( 1 Royal Institute of Technology 2 Ulf Andersson Bj o rn Lyxell Jerker Ro nnberg

Effects of Tactile Training on Visual Speechreading: Performance Changes Related to Individual Differences in Cognitive Skills

Ulla-Britt Persson for checking the lan- Behavioral Sciences, Linkoping University , S-581 83 Linkoping, Sweden ( 1 Royal Institute of Technology 2 Ulf Andersson Bj orn Lyxell Jerker Ronnberg Linkoping

Vibrotactile Speech Tracking Support: Cognitive Prerequisites

Fourteen postlingually hearing-impaired participants took part in an intervention study on the potential benefit of three types of tactile aids (i.e., the Tactilator, Minivib 3, and the Tactaid 7). Although training by means of computerized tracking had substantial effects on speech tracking rate, no differential effects of type of aid emerged. However, a cognitive test battery...

Whole-genome expression profiling through fragment display and combinatorial gene identification

There is a growing demand for highly parallel gene expression analysis with whole genome coverage, high sensitivity and high accuracy. Open systems such as differential display are capable of analyzing most of the expressed genome but are not quantitative and generally require manual identification of differentially expressed genes by sequencing. Closed systems such as...

High Mobility Group Box Chromosomal Protein 1 (HMGB1) Is an Antibacterial Factor Produced by the Human Adenoid

Antibacterial factors were purified from human adenoid glands by tissue extraction and consecutive steps of reversed-phase chromatography and assayed for bactericidal activity against the airway pathogen Moraxella catarrhalis and also Escherichia coli and Bacillus megaterium. One of the most active components isolated from adenoids was identified by N-terminal sequence analysis...

Tesaglitazar, a PPARα/γ Agonist, Induces Interstitial Mesenchymal Cell DNA Synthesis and Fibrosarcomas in Subcutaneous Tissues in Rats

The development of the dual peroxisome proliferator–activated receptor (PPAR) α/γ agonist tesaglitazar as an oral antidiabetic was recently discontinued. Here we present tumor data from a 2-year carcinogenicity study in rats given 0.3, 1, 3, and 10 μmol/kg tesaglitazar is presented with focus on the findings of subcutaneous fibrosarcomas. To investigate the mechanism for...