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Toll-Like Receptor 4 Mediates Endothelial Cell Activation Through NF-κB but Is Not Associated with Endothelial Dysfunction in Patients with Rheumatoid Arthritis

Objective To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA). Methods Human aortic endothelial cells (HAECs) were treated with lipopolysaccharide (LPS), OxPAPC, and free fatty acids (FFA) at...

Sex-Specific Effects of Cardiovascular Risk Factors on Endothelium-Dependent Dilation and Endothelin Activity in Middle-Aged Women and Men

Background Healthy middle-aged postmenopausal women have higher endothelium-dependent dilation and lower vasoconstrictor activity of endothelin-1 than men. Whether these sex-specific differences extend to patients with cardiovascular risk factors has not been investigated. The current study aimed to determine whether, in patients with cardiovascular risk factors, sex-specific...

Obesity-Related Metabolic Syndrome and Vascular Complications

between obesity, MetS, T2DM, and cardiovascular disease. Manfredi Tesauro Micaela Iantorno Umberto Campia References S. R. Bornstein, M. Ehrhart-Bornstein, M. L. Wong, and J. Licinlo, “Is the

Obesity-Related Metabolic Syndrome and Vascular Complications

between obesity, MetS, T2DM, and cardiovascular disease. Manfredi Tesauro Micaela Iantorno Umberto Campia References S. R. Bornstein, M. Ehrhart-Bornstein, M. L. Wong, and J. Licinlo, “Is the

Obesity-Related Metabolic Syndrome and Vascular Complications

between obesity, MetS, T2DM, and cardiovascular disease. Manfredi Tesauro Micaela Iantorno Umberto Campia References S. R. Bornstein, M. Ehrhart-Bornstein, M. L. Wong, and J. Licinlo, “Is the

Effects of GLP-1 on Forearm Vasodilator Function and Glucose Disposal During Hyperinsulinemia in the Metabolic Syndrome

MANFREDI TESAURO FRANCESCA SCHINZARI ANGELO ADAMO VALENTINA ROVELLA FRANCESCA MARTINI NADIA MORES ANGELA BARINI DARIO PITOCCO GIOVANNI GHIRLANDA DAVIDE LAURO UMBERTO CAMPIA CARMINE CARDILLO C a r d

Arterial Wall Properties and Womersley Flow in Fabry Disease

Fabry disease is an X-linked recessive lysosomal storage disease resulting in the cellular accumulation of globotriaosylceramide particularly globotriaosylceramide. The disease is characterized by a dilated vasculopathy with arterial ectasia in muscular arteries and arterioles. Previous venous plethysomographic studies suggest enhanced endothelium-dependent vasodilation in Fabry...

Arterial Wall Properties and Womersley Flow in Fabry Disease

, Umberto Campia 4, Julio A Panza 4, Emilios Dimitriadis 3 and Raphael Schiffmann *1 E-mail: David F Moore - dfm 2 @helix.nih.gov Gheona Altarescu - Randall Pursley - Umberto Campia - Julio A Panza