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Effect of nicotinamide treatment on the residual insulin secretion in Type 1 (insulin-dependent) diabetic patients

SummaryIn vivo and in vitro experiments have shown that nicotinamide enhances the regeneration of rat B cells. Nicotinamide has been administered to human subjects at a dose of 3 g/day for more than one year without any serious side effects. A trial was conducted to study if nicotinamide could protect B cells in Type I (insulin-dependent) diabetic patients with established...

Low acute insulin response to intravenous glucose. A sensitive but non-specific marker of early stages of Type 1 (insulin-dependent) diabetes

SummaryPreventive treatment of Type 1 (insulin-dependent) diabetes presupposes early and accurate diagnosis of prediabetic states. The low acute insulin response to intravenous glucose has been proposed as a marker of both pre-Type 1 and pre-Type 2 (non-insulin-dependent) diabetes. In order to test the reliability of this marker for clinical detection of Type 1 diabetes we looked...

Kinetics of fast haemoglobin in diabetic rats

This study was designed to examine the appearance and disappearance kinetics of glycosylated haemoglobin during abrupt changes of blood glucose in the rat. The concentration of the fast haemoglobin component, which has similar chromatographic and electrophoretic profiles to human haemoglobin A1, was measured after the induction of diabetes by streptozotocin and its cure by...

Relation entre l'inhibition pancréatique induite par l'alcool et la concentration plasmatique du polypeptide pancréatique, du VIP et de la somatostatine

F. DESCOS V. LASSMANN P. VAGUE Unité de Recherches de Pathologie Digestive, INSERM U 0 Mott C. , Sarles H., Tiscornia O. M., Gullo L., 1972 Chez l'homme et le chien non alcoolique, l'alcool

Relation entre l'inhibition pancréatique induite par l'alcool et la concentration plasmatique du polypeptide pancréatique, du VIP et de la somatostatine

F. DESCOS V. LASSMANN P. VAGUE Unité de Recherches de Pathologie Digestive, INSERM U 0 Mott C. , Sarles H., Tiscornia O. M., Gullo L., 1972 Chez l'homme et le chien non alcoolique, l'alcool