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23 papers found.
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Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse

Insulin secretion declines progressively before and during the course of type 2 diabetes. Evidence indicates that this process is, in part, secondary to increased requirement for insulin secretion that is brought about by insulin resistance and by hyperglycemia. The effects of over-secretion extend far beyond a mere reduction of available insulin stores and may cause not only...

Aminoguanidine Exerts a β-Cell Function-preserving Effect in High Glucose-cultured β-Cells (INS-1)

Aminoguanidine Exerts a fi-cell Function-preserving Effect in High Glucose-cultured fi-cells (INS-l) YUJI TAJIRI VALDEMAR GRILL *Corresponding author. Tel.: +47-73868386, Fax: +47-73867546, e-mail

Type 2 Diabetes—Effect of Compensatory Oversecretion as a Reason for β-Cell Collapse

Insulin secretion declines progressively before and during the course of type 2 diabetes. Evidence indicates that this process is, in part, secondary to increased requirement for insulin secretion that is brought about by insulin resistance and by hyperglycemia. The effects of over-secretion extend far beyond a mere reduction of available insulin stores and may cause not only...

Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study

Background Our aim was to assess the influence of age, gender and lifestyle factors on the effect of the obesity-promoting alleles of FTO and MCR4. Methods The HUNT study comprises health information on the population of Nord-Trøndelag county, Norway. Extreme phenotype participants (gender-wise lower and upper quartiles of waist-hip-ratio and BMI ≥ 35 kg/m2) in the third survey...

Mitochondrial Respiration in Insulin-Producing β-Cells: General Characteristics and Adaptive Effects of Hypoxia

Objective To provide novel insights on mitochondrial respiration in β-cells and the adaptive effects of hypoxia. Methods and Design Insulin-producing INS-1 832/13 cells were exposed to 18 hours of hypoxia followed by 20–22 hours re-oxygenation. Mitochondrial respiration was measured by high-resolution respirometry in both intact and permeabilized cells, in the latter after...

Fructosamine Is a Useful Indicator of Hyperglycaemia and Glucose Control in Clinical and Epidemiological Studies – Cross-Sectional and Longitudinal Experience from the AMORIS Cohort

Context Fructosamine is a glycemic biomarker which may be useful for indication and control of diabetes respectively. Objective The objective of the study was to evaluate fructosamine as an indicator of hyperglycaemia and glucose control in subjects with diabetes. Design, Setting & Patients From the AMORIS cohort, subjects with serum glucose, fructosamine and HbA1c from the same...

Mortality in Adult-Onset Autoimmune Diabetes Is Associated With Poor Glycemic Control: Results from the HUNT Study

in Adult-Onset Autoimmune Diabetes Is Associated With Poor Glycemic Control LISA OLSSON PHD VALDEMAR GRILL PHD KRISTIAN MIDTHJELL PHD ANDERS AHLBOM PHD TOMAS ANDERSSON BSC SOFIA CARLSSON PHD E p i d

Smoking Is Associated With Reduced Risk of Autoimmune Diabetes in Adults Contrasting With Increased Risk in Overweight Men With Type 2 Diabetes: A 22-year follow-up of the HUNT study

BAHAREH RASOULI MSC VALDEMAR GRILL PHD KRISTIAN MIDTHJELL PHD ANDERS AHLBOM PHD TOMAS ANDERSSON MSC SOFIA CARLSSON PHD E p i d e m i o l o g y / H e a l t h OBJECTIVEdTo investigate the association

Preconditioning with Associated Blocking of Ca2+ Inflow Alleviates Hypoxia-Induced Damage to Pancreatic β-Cells

Objective Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia. Methods and Design Rat and human pancreatic islets were subjected to 5.5 h of hypoxia after which functional and viability parameters were measured...

C-Peptide Levels in Latent Autoimmune Diabetes in Adults Treated With Linagliptin Versus Glimepiride: Exploratory Results From a 2-Year Double-Blind, Randomized, Controlled Study

years) with lower C-peptide levels (821944 vs. 1,3261,425 pmol/L), whereas HbA1c levels were similar (Table 1). Odd Erik Johansen,1 Bernhard O. Boehm,2,3 Valdemar Grill,4 Peter A. Torjesen,5 Sudipta

High Levels of Education Are Associated With an Increased Risk of Latent Autoimmune Diabetes in Adults: Results from the Nord-Trøndelag Health Study

LISA OLSSON MSC ANDERS AHLBOM PHD VALDEMAR GRILL PHD KRISTIAN MIDTHJELL PHD SOFIA CARLSSON PHD E p i d e m i o l o g y / H e a l t h OBJECTIVE - To investigate whether the risk for autoimmune

Genetic Heterogeneity in Latent Autoimmune Diabetes Is Linked to Various Degrees of Autoimmune Activity: Results From the Nord-Trøndelag Health Study

Elin Pettersen Frank Skorpen Kirsti Kvaly Kristian Midthjell Valdemar Grill OBJECTIVE-Previous studies have indicated that the latent autoimmune diabetes in adults (LADA) phenotype is heterogeneous

Influence of Family History of Diabetes on Incidence and Prevalence of Latent Autoimmune Diabetes of the Adult: Results from the Nord-Trøndelag Health Study

OBJECTIVE—The aim of this study was to investigate the association between family history of diabetes (FHD) and prevalence and incidence of latent autoimmune diabetes of the adult (LADA), type 1 diabetes, and type 2 diabetes. RESEARCH DESIGN AND METHODS—The results were based on cross-sectional data from 64,498 men and women (aged ≥20 years) who were in the Nord-Trøndelag Health...

Heterogeneity of Patients With Latent Autoimmune Diabetes in Adults: Linkage to Autoimmunity Is Apparent Only in Those With Perceived Need for Insulin Treatment: Results from the Nord-Trøndelag Health (HUNT) study

MARIA A. RADTKE KRISTIAN MIDTHJELL PHD TOM I. LUND NILSEN PHD VALDEMAR GRILL PHD OBJECTIVE Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA) are more prone to need insulin

Effects of Diazoxide on Gene Expression in Rat Pancreatic Islets Are Largely Linked to Elevated Glucose and Potentially Serve to Enhance β-Cell Sensitivity

Zuheng Ma Neil Portwood David Brodin Valdemar Grill Anneli Bj orklund Diazoxide enhances glucose-induced insulin secretion from -cells through mechanisms that are not fully elucidated. Here, we

Peripheral Sensory Neuropathy Associates With Micro- or Macroangiopathy: Results from a population-based study of type 2 diabetic patients in Sweden

LARS K ARVESTEDT EVA MRTENSSON VALDEMAR GRILL PHD STIG ELOFSSON PHD GUNVOR VON WENDT PHD ANDERS HAMSTEN PHD KERSTIN BRISMAR PHD OBJECTIVE - To assess associations between peripheral sensory

Six Months of Diazoxide Treatment at Bedtime in Newly Diagnosed Subjects With Type 1 Diabetes Does Not Influence Parameters of β-Cell Function and Autoimmunity but Improves Glycemic Control

OBJECTIVE Continuous β-cell rest with diazoxide preserves residual endogenous insulin production in type 1 diabetes. However, side effects have hampered therapeutic usefulness. In a double-blind study, we tested whether lower, intermittent dosing of diazoxide had beneficial effects on insulin production, metabolic control, and autoimmunity markers in the absence of side effects...

Alcohol Consumption and the Incidence of Type 2 Diabetes: A 20-year follow-up of the Finnish Twin Cohort Study

OBJECTIVE—The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS—The study population consisted of 22,778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. Information on alcohol, smoking, diet, physical activity...