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12 papers found.
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Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans

Gelpke, Hans M. G. Princen, Dennie Tempel. Data curation: Valur Emilsson, Ljubica Perisic Matic. Formal analysis: Danielle van Keulen, Marianne G. Pouwer, Valur Emilsson, Ljubica Perisic Matic. Funding ... acquisition: Alain J. van Gool. Investigation: Danielle van Keulen, Marianne G. Pouwer, Valur Emilsson, Ljubica Perisic Matic, Kim Holmstr?m, Boye Schnack Nielsen, Jan H. N. Lindeman. Methodology: Danielle

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

Gudnason, Christopher J Kenyon, Jonathan R Seckl, Brian R Walker, Scott P Webster, Donald R Dunbar, Gary A Churchill, Antonio Vidal-Puig , Jose? Manuel Fernandez-Real, Valur Emilsson & Simon Horvat Nat. Med

Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs

Background Gene expression genetic studies in human tissues and cells identify cis- and trans-acting expression quantitative trait loci (eQTLs). These eQTLs provide insights into regulatory mechanisms underlying disease risk. However, few studies systematically characterized eQTL results across cell and tissues types. We synthesized eQTL results from >50 datasets, including new...

Dissecting Cis Regulation of Gene Expression in Human Metabolic Tissues

Complex diseases such as obesity and type II diabetes can result from a failure in multiple organ systems including the central nervous system and tissues involved in partitioning and disposal of nutrients. Studying the genetics of gene expression in tissues that are involved in the development of these diseases can provide insights into how these tissues interact within the...

Characterizing Dynamic Changes in the Human Blood Transcriptional Network

Gene expression data generated systematically in a given system over multiple time points provides a source of perturbation that can be leveraged to infer causal relationships among genes explaining network changes. Previously, we showed that food intake has a large impact on blood gene expression patterns and that these responses, either in terms of gene expression level or gene...

Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat

Fat Identifies a Unique Locus for Ectopic Fat Caroline S. Fox Charles C. White Kurt Lohman Nancy Heard-Costa Paul Cohen Yingying Zhang Andrew D. Johnson Valur Emilsson Ching-Ti Liu Y.-D. Ida Chen Kent

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Background Circadian (diurnal) rhythm is an integral part of the physiology of the body; specifically, sleep, feeding behavior and metabolism are tightly linked to the light-dark cycle dictated by earth's rotation. Methods The present study examines the effect of diurnal rhythm on gene expression in the subcutaneous adipose tissue of overweight to mildly obese, healthy...

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Circadian (diurnal) rhythm is an integral part of the physiology of the body; specifically, sleep, feeding behavior and metabolism are tightly linked to the light-dark cycle dictated by earth's rotation. The present study examines the effect of diurnal rhythm on gene expression in the subcutaneous adipose tissue of overweight to mildly obese, healthy individuals. In this well...

Thiolation of transfer RNA in Escherichia coli varies with growth rate

We have used an affinity electrophoresis assay which when combined with Northern hybridization techniques permits us to estimate the degree of thiolation of individual tRNA species in Escherichia coli. We observe that the levels of 4-thio 2′(3′)-uridine (4-thioU) in many but not all tRNAs varies dramatically at different bacterial growth rates: Five tRNAs are completely thiolated...

Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion

Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and is mutated in the db/db mouse so that it lacks the cytoplasmic domain. We show that the full-length leptin receptor (Ob-Rb), which is believed to transmit the leptin signal, is expressed in pancreatic islets of ob/ob and...

Predictive Genes in Adjacent Normal Tissue Are Preferentially Altered by sCNV during Tumorigenesis in Liver Cancer and May Rate Limiting

Background In hepatocellular carcinoma (HCC) genes predictive of survival have been found in both adjacent normal (AN) and tumor (TU) tissues. The relationships between these two sets of predictive genes and the general process of tumorigenesis and disease progression remains unclear. Methodology/Principal Findings Here we have investigated HCC tumorigenesis by comparing gene...

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring...