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Search: authors:"Vanessa Bloch"

4 papers found.
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A Decision Support Tool Facilitating Medicine Design for Optimal Acceptability in The Older Population

PurposeMedicine acceptability, which is of the utmost importance for vulnerable patients’ adherence, is driven by both user and product characteristics. Herein, a novel multivariate approach integrating the many aspects of acceptability is used to discriminate positively and negatively accepted medicines in the older population.MethodsAn observational study was carried out in...

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigated in acute poisonings. The aim of this study was to describe the relationships between...

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigated in acute poisonings. The aim of this study was to describe the relationships between...

Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles

Introduction Prognostic factors in intentional insulin self-poisoning and the significance of plasma insulin levels are unclear. We therefore conducted this study to investigate prognostic factors in insulin poisoning, in relation to the value of plasma insulin concentration. Methods We conducted a prospective study, and used logistic regression to explore prognostic factors and...