Advanced search    

Search: authors:"Vladimir Bilim"

5 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition

Background The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin 1 (mTORC1) signaling pathway is aberrantly activated in renal cell carcinoma (RCC). We previously demonstrated glycogen synthase kinase-3β (GSK-3β) positively regulated RCC proliferation. The aim of this study was to evaluate the role of GSK-3 in the PI3K/Akt/mTORC1 pathway and regulation of the...

Long term survival in a case of concurrent retroperitoneal liposarcoma and renal cell carcinoma: a case report

BackgroundLiposarcoma is one of the most common soft tissue sarcomas found in adults. It has a predilection for retroperitoneal space. Renal cell carcinoma is the most common tumor of the kidney.Case presentationConcurrent retroperitoneal liposarcoma and renal cell carcinoma were found in a 34-year-old Japanese man. The renal tumor was first detected by ultrasonography, it was...

A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression

Background Pathological stage and grade have limited ability to predict the outcomes of superficial urothelial bladder carcinoma at initial transurethral resection (TUR). AT-motif binding factor 1 (ATBF1) is a tumor suppressive transcription factor that is normally localized to the nucleus but has been detected in the cytoplasm in several cancers. Here, we examined the diagnostic...

Associations Among β-TrCP, an E3 Ubiquitin Ligase Receptor, β-Catenin, and NF-κB in Colorectal Cancer

Background: The ubiquitin–proteasome pathway is important in regulating protein signaling pathways that are involved in tumorigenesis. β-transducin repeat–containing proteins (β-TrCP) are components of the ubiquitin ligase complex targeting β-catenin and IκBα for proteasomal degradation and are thus a negative regulator of Wnt/β-catenin signaling and a positive regulator of NF-κB...

Fc receptor‐mediated accumulation of macrophages in crescentic glomerulonephritis induced by anti‐glomerular basement membrane antibody administration in WKY rats

Anti‐glomerular basement membrane (GBM) glomerulonephritis induced in WKY rats is characterized by glomerular accumulation of CD8+ T cells and monocytes/macrophages, followed by crescent formation. The mechanism of leukocyte accumulation after antibody binding to GBM is still unclear. To unveil an involvement of Fcγ receptors (FcγR) in leukocytes recruitment we examined the...