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Search: authors:"Walter Pirker"

8 papers found.
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Individual cognitive change after DBS-surgery in Parkinson’s disease patients using Reliable Change Index Methodology

SummaryLong-term therapy of Parkinson’s disease (PD) with levodopa (L-DOPA) is associated with a high risk of developing motor fluctuations and dyskinesia. Deep brain stimulation (DBS) in PD patients of the subthalamic nucleus can improve these motor complications. Although the positive effect on motor symptoms has been proven, postoperative cognitive decline has been documented...

Gait disorders in adults and the elderly

Human gait depends on a complex interplay of major parts of the nervous, musculoskeletal and cardiorespiratory systems. The individual gait pattern is influenced by age, personality, mood and sociocultural factors. The preferred walking speed in older adults is a sensitive marker of general health and survival. Safe walking requires intact cognition and executive control. Gait...

Antipsychotikainduzierte tardive Syndrome

ZusammenfassungTardive Syndrome bleiben trotz des vermehrten Einsatzes von Antipsychotika der neuen Generation ein relevantes klinisches Problem. Es handelt sich um schwer behandelbare Bewegungsstörungen mit geringer Rückbildungstendenz. Deswegen ist die Prophylaxe von entscheidender Bedeutung, wobei der verantwortungsvolle Einsatz von Antipsychotika im Vordergrund steht. Für die...

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

In Parkinson’s disease (PD) the prevalence of apraxia increases with disease severity implying that patients in early stages may already have subclinical deficits. The aim of this exploratory fMRI study was to investigate if subclinical aberrations of the praxis network are already present in patients with early PD. In previous functional imaging literature only data on basal...

Rare Variants in PLXNA4 and Parkinson’s Disease

Approximately 20% of individuals with Parkinson’s disease (PD) report a positive family history. Yet, a large portion of causal and disease-modifying variants is still unknown. We used exome sequencing in two affected individuals from a family with late-onset familial PD followed by frequency assessment in 975 PD cases and 1014 ethnically-matched controls and linkage analysis to...

Rare variants in LRRK1 and Parkinson's disease

Approximately 20 % of individuals with Parkinson's disease (PD) report a positive family history. Yet, a large portion of causal and disease-modifying variants is still unknown. We used exome sequencing in two affected individuals from a family with late-onset PD to identify 15 potentially causal variants. Segregation analysis and frequency assessment in 862 PD cases and 1,014...