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The Danube Corridor Hypothesis and the Carpathian Basin: Geological, Environmental and Archaeological Approaches to Characterizing Aurignacian Dynamics

Early Upper Paleolithic sites in the Danube catchment have been put forward as evidence that the river was an important conduit for modern humans during their initial settlement of Europe. Central to this model is the Carpathian Basin, a region covering most of the Middle Danube. As the archaeological record of this region is still poorly understood, this paper aims to provide a...

Impact of universal drug susceptibility testing and effective management of multidrug-resistant tuberculosis in Taiwan

with data analysis. Author Contributions Conceptualization: Pin-Hui Lee, Chen-Yuan Chiang. Data curation: Pei-Chun Chan, Yen-Ting Peng, Po-Wei Chu, Mei-Hua Wu, Ruwen Jou, Ming-Chih Yu, Chou-Jui Lin ... , Yi-Wen Huang, Shun-Tien Chien, Jen-Jyh Lee. Formal analysis: Pin-Hui Lee, Chen-Yuan Chiang. Investigation: Pei-Chun Chan, Yen-Ting Peng, Po-Wei Chu, Mei-Hua Wu, Ruwen Jou, Ming-Chih Yu, Chou-Jui Lin

SOX2 promoter hypermethylation in non-smoking Taiwanese adults residing in air pollution areas

BackgroundBoth SOX2 promoter methylation and air pollution have been associated with lung cancer risk. However, little has been done to assess SOX2 promoter methylation in individuals living in air pollution areas. The aim of this study was to investigate SOX2 promoter methylation in non-smoking Taiwanese adults living in areas with different levels of air pollution especially...

Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment

BackgroundBecause of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells. However, there is limited or conflicting evidence pertaining to whether nasal samples can be surrogates to bronchial samples. The goal of the present study is to...

IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells

1U19AI125357 that were awarded to Hong Wei Chu. Among the authors, Yoko Ito, William Janssen, James Finigan and Hong Wei Chu received the salary support from these NIH grants. The funder (NIH) had no role in ... Conceptualization: Yoko Ito, Hong Wei Chu. Data curation: Yoko Ito, Nicole Roberts. Formal analysis: Yoko Ito. Funding acquisition: Hong Wei Chu. Investigation: Yoko Ito, Reem Al Mubarak, Nicole Roberts

ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study

-Cheng Chou 6 Hou-Wei Chu 6 Shun-Jen Chang 7 Wei-Ting Liao 8 9 0 Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital , Kaohsiung , Taiwan 1

Fabrication of polarization-independent waveguides deeply buried in lithium niobate crystal using aberration-corrected femtosecond laser direct writing

Chu Ya Cheng OPEN Writing optical waveguides with femtosecond laser pulses provides the capability of forming threedimensional photonic circuits for manipulating light fields in both linear and

Promotion Effect of CaO Modification on Mesoporous Al2O3-Supported Ni Catalysts for CO2 Methanation

The catalysts Ni/Al2O3 and CaO modified Ni/Al2O3 were prepared by impregnation method and applied for methanation of CO2. The catalysts were characterized by N2 adsorption/desorption, temperature-programmed reduction of H2 (H2-TPR), X-ray diffraction (XRD), and temperature-programmed desorption of CO2 and H2 (CO2-TPD and H2-TPD) techniques, respectively. TPR and XRD results...

Promotion Effect of CaO Modification on Mesoporous Al2O3-Supported Ni Catalysts for CO2 Methanation

The catalysts Ni/Al2O3 and CaO modified Ni/Al2O3 were prepared by impregnation method and applied for methanation of CO2. The catalysts were characterized by N2 adsorption/desorption, temperature-programmed reduction of H2 (H2-TPR), X-ray diffraction (XRD), and temperature-programmed desorption of CO2 and H2 (CO2-TPD and H2-TPD) techniques, respectively. TPR and XRD results...

Tailoring femtosecond 1.5-μm Bessel beams for manufacturing high-aspect-ratio through-silicon vias

Three-dimensional integrated circuits (3D ICs) are an attractive replacement for conventional 2D ICs as high-performance, low-power-consumption, and small-footprint microelectronic devices. However, one of the major remaining challenges is the manufacture of high-aspect-ratio through-silicon vias (TSVs), which is a crucial technology for the assembly of 3D Si ICs. Here, we...

α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke

α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke Reena Berman, Di Jiang, Qun Wu, Hong Wei Chu Department of Medicine, National Jewish

A Study of CO2 Methanation over Ni-Based Catalysts Supported by CNTs with Various Textural Characteristics

This work studied the influence of textural characteristics of CNTs on catalytic performance of Ni/CNTs for CO2 methanation. The CNTs supports were prepared by chemical vapor deposition method using Ni/MgO catalysts, and acetonitrile and ethanol were used as carbon sources, respectively. The Ni/CNTs catalysts were prepared via impregnation method and characterized by X-ray...

Photoconductivities in MoS2 Nanoflake Photoconductors

Shen et al. Nanoscale Research Letters Photoconductivities in MoS Nanoflake 2 Photoconductors Wei-Chu Shen Ruei-San Chen 0 Ying-Sheng Huang 0 Graduate Institute of Applied Science and Technology

MUC18 Regulates Lung Rhinovirus Infection and Inflammation

Background MUC18 is upregulated in the lungs of asthma and COPD patients. It has been shown to have pro-inflammatory functions in cultured human airway epithelial cells during viral infections and in mice during lung bacterial infections. However, the in vivo role of MUC18 in the context of viral infections remains poorly understood. The goal of this study is to define the in...

Transverse writing of three-dimensional tubular optical waveguides in glass with a slit-shaped femtosecond laser beam

We report on fabrication of tubular optical waveguides buried in ZBLAN glass based on transverse femtosecond laser direct writing. Irradiation in ZBLAN with focused femtosecond laser pulses leads to decrease of refractive index in the modified region. Tubular optical waveguides of variable mode areas are fabricated by forming the four sides of the cladding with slit-shaped...

Change of government’s subsidization policy improves smoking cessation services: a cross-sectional study from the perspectives of physicians

Background The Taiwanese government increased financial subsidies for smoking cessation services in 2012. We aimed to evaluate the effects of this new policy on smoking cessation services from the physician’s perspective. Methods This was a cross-sectional nationwide survey. Physicians who provided smoking cessation services for more than ten patient encounters in the preceding...

Simultaneous identification of multi-combustion-intermediates of alkanol-air flames by femtosecond filament excitation for combustion sensing

Laser filamentation produced by the propagation of intense laser pulses in flames is opening up new possibility in application to combustion diagnostics that can provide useful information on understanding combustion processes, enhancing combustion efficiency and reducing pollutant products. Here we present simultaneous identification of multiple combustion intermediates by...

Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice

Cystic fibrosis (CF) is a genetic disease with many airway pathological features, including aberrant epithelial sodium channel (ENaC) function, persistent Pseudomonas aeruginosa (PA) infection and neutrophil-dominant inflammation. PA infection in CF airways is difficult to treat due to antibiotic resistance and other factors. Recently, α1-antitrypsin (A1AT) have been shown to be...