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Quantitative proteomic analysis of prostate tissue specimens identifies deregulated protein complexes in primary prostate cancer

BackgroundProstate cancer (PCa) is the most frequently diagnosed non-skin cancer and a leading cause of mortality among males in developed countries. However, our understanding of the global changes of protein complexes within PCa tissue specimens remains very limited, although it has been well recognized that protein complexes carry out essentially all major processes in living...

Luminescent sensing film based on sulfosalicylic acid modified Tb(III)-doped yttrium hydroxide nanosheets

Sulfosalicylic acid (SSA) was used as an intercalation agent and an excellent antenna to synthesize layered rare-earth hydroxide (LRH) materials and directly obtain SSA-modified terbium-doped ytterbium hydroxide nanosheets by mechanical exfoliation. The crystal structure and morphologies of the LRHs and nanosheets were determined by X-ray diffraction, scanning electron microscopy...

Effects of Landscape Design on Urban Microclimate and Thermal Comfort in Tropical Climate

© 2018 Wei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the

Trade-Off Analysis to Determine Environmental Flows in a Highly Regulated Watershed

Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, ChinaAiping Pang, Chunhui Li, Tao Sun, Wei Yang & Zhifeng YangDepartment of Public Management ... journals • PubMed • Google Scholar Search for Tao Sun in:Nature Research journals • PubMed • Google Scholar Search for Wei Yang in:Nature Research journals • PubMed • Google Scholar Search for Zhifeng

Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach

peptide. (PDF) Conceptualization: Prediman K. Shah, Bojan Cercek, Paul C. Dimayuga. Formal analysis: Peter M. Mihailovic, Wai Man Lio, Wei Yang. Funding acquisition: Prediman K. Shah, Bojan Cercek ... . Investigation: Peter M. Mihailovic, Romana Herscovici, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Bo Zhou, Wei Yang, Paul C. Dimayuga. Methodology: Peter M. Mihailovic, Wai Man Lio, Kuang-Yuh Chyu, Michael R

Renal chymase-dependent pathway for angiotensin II formation mediated acute kidney injury in a mouse model of aristolochic acid I-induced acute nephropathy

Chiao Tung University and Ministry of Education (MOE), Taiwan. Author Contributions Conceptualization: Chia-Chu Chang. Investigation: Li-Che Lu. Methodology: Li-Che Lu, Chung-Wei Yang. Project ... Lu, Chung-Wei Yang. Writing ? original draft: Wen-Yeh Hsieh, Teng-Hsiang Chang, Hui-Fang Chang, Wan Hsuan Chuang. Writing ? review & editing: Chih-Sheng Lin, Chia-Chu Chang. 12 / 15 13 / 15 14 / 15

Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression

Human immunodeficiency virus type 1 (HIV-1) Tat protein plays an essential role in HIV-1 gene transcription. Tat transactivates HIV-1 long terminal repeat (LTR)-directed gene expression through direct interactions with the transactivation-responsive region (TAR) element and other cis elements in the LTR. The TAR-independent Tat-mediated LTR transactivation is modulated by several...

Reliability Assessment for the Solenoid Valve of a High-Speed Train Braking System under Small Sample Size

manuscript. Authors’ Information Jian-Wei Yang, born in 1971, is currently a professor at Beijing University of Civil Engineering Architecture, China. He received his Ph.D. degree from China Academy of

A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast

We introduce a novel “mathematical pathology” approach, founded on a biophysical model, to identify robust patient-specific predictors of tumor growth useful in clinical practice to improve the accuracy of diagnosis/prognosis and intervention. In accordance with biological observations, our model simulates the diffusion-limited in situ tumors with a relatively short phase of fast...

New gauge boson \(W^\prime \) and radiative leptonic decays of charged B and D mesons

Considering the constraints on model parameters from the latest experimental data, we study the contributions of new gauge boson \(W^\prime \) predicted by the general 221 models to the radiative leptonic decays of charged B and D mesons. It is found that the largest contributions of \(W^\prime \) in the non-universal 221 model to the branching fractions occur in the decay modes...

Role of Gated Myocardial Glucose Metabolic Imaging in Assessing Left Ventricular Systolic Dyssynchrony after Myocardial Infarction and the Influential Factors

In this study, we investigated the role of gated myocardial glucose metabolic imaging in assessing left ventricular (LV) systolic dyssynchrony after myocardial infarction (MI) and explored the influencing factors. Bama mini-pigs were divided into normal group and MI group and subjected to gated myocardial metabolic imaging (GMMI) and gated myocardial perfusion imaging (GMPI). The...

Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro

Drug resistance of paclitaxel (TAX), the first-line chemotherapy drug for breast cancer, was reported to develop in 90% of patients with breast cancer, especially metastatic breast cancer. Investigating the mechanism of TAX resistance of breast cancer cells and developing the strategy improving its therapeutic efficiency are crucial to breast cancer cure. We here report an...

Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors

It is important that the correct amounts of GluN2 subunits are maintained, as they determine NMDAR functional properties, which are crucial to neuronal communication, synaptogenesis and cognitive function. The transcriptional repressor RE1 silencing transcription factor (REST) is critical for the postnatal developmental switch in NMDARs. However, the mechanisms triggering REST...

Surgical margin status and its impact on prostate cancer prognosis after radical prostatectomy: a meta-analysis

Background and purposePositive surgical margins (PSMs) correlate with adverse outcomes in numerous solid tumours. However, the prognostic value of PSMs in prostate cancer (PCa) patients who underwent radical prostatectomy remains unclear. Herein, we performed a meta-analysis to evaluate the association between PSMs and the prognostic value for biochemical recurrence-free survival...

Strain-Tunable Electronic Properties and Band Alignments in GaTe/C2N Heterostructure: a First-Principles Calculation

Recently, GaTe and C2N monolayers have been successfully synthesized and show fascinating electronic and optical properties. Such hybrid of GaTe with C2N may induce new novel physical properties. In this work, we perform ab initio simulations on the structural, electronic, and optical properties of the GaTe/C2N van der Waals (vdW) heterostructure. Our calculations show that the...

New Riesz representations of linear maps associated with certain boundary value problems and their applications

In this paper, we obtain new Riesz representations of continuous linear maps associated with certain boundary value problems in the set of all closed bounded convex non-empty subsets of any Banach space. As applications, the Riesz integral representation results are also given.

The effectiveness and cost-effectiveness of plant sterol or stanol-enriched functional foods as a primary prevention strategy for people with cardiovascular disease risk in England: a modeling study

This study appraises the effectiveness and cost-effectiveness of consumption of plant sterol-enriched margarine-type spreads for the prevention of cardiovascular disease (CVD) in people with hypercholesterolemia in England, compared to a normal diet. A nested Markov model was employed using the perspective of the British National Health Service (NHS). Effectiveness outcomes were...

Monosulfonicpillar[5]arene: Synthesis, Characterization, and Complexation with Tetraphenylethene for Aggregation-Induced Emission

A pillar[5]arene derivative with a hydrophilic sulfonic group, i.e., monosulfonicpillar[5]arene (MSP5), has been successfully synthesized for the first time, which exhibited strong binding affinity towards alcohol analogs. Significantly, fluorescent supramolecular ensemble was fabricated from the supramolecular complexation of MSP5 and a neutral guest with tetraphenylethene core...