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MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy

and experimental condition support. Author Contributions Wei?Zeng and Bing?Feng designed the experiment scheme and wrote the paper. Wei?Qi and Jian-Ying?Tang prepared figures 1?2. Jiao?Mu prepared

Metacaspase gene family in Rosaceae genomes: Comparative genomic analysis and their expression during pear pollen tube and fruit development

drought-tolerant for 6h, Accession: SRX4110142; P. bretschneideri for 24 h, Accession: SRX4110139 Author Contributions Formal analysis: Yu Chen. Resources: Wei Zeng, Lei Zhang, Qi Wang, Wei Hen, Muhammad

A Novel Combination Co-Kriging Model Based on Gaussian Random Process

of Mechanical Engineering, Xi’an Shiyou University, China 3RG Petro-Machinery(Group) Co., Ltd., China Correspondence should be addressed to Wei Zeng; ten.haey@7891iewgnez Received 25 May 2018

Medium of Instruction in Secondary Education in Post-Colonial Hong Kong: Why Chinese? Why English?

bilingual programs or including more English instruction. Wei Zeng is currently a doctoral student in Educational Linguistics in the Graduate School of Education at the University of Pennsylvania. Her

An Improved Rollover Index Based on BP Neural Network for Hydropneumatic Suspension Vehicles

The 3-DOF rollover model has been established by the Lagrangian second-class equation, taking the road inclination angle, the steering strategy, and the hydropneumatic suspension characteristics into consideration. A 3-layer BP (backpropagation) neural network is applied to predict the road inclination angle and to optimize the rollover model in real-time. The number of the...

An Improved Rollover Index Based on BP Neural Network for Hydropneumatic Suspension Vehicles

The 3-DOF rollover model has been established by the Lagrangian second-class equation, taking the road inclination angle, the steering strategy, and the hydropneumatic suspension characteristics into consideration. A 3-layer BP (backpropagation) neural network is applied to predict the road inclination angle and to optimize the rollover model in real-time. The number of the...

An Improved Rollover Index Based on BP Neural Network for Hydropneumatic Suspension Vehicles

The 3-DOF rollover model has been established by the Lagrangian second-class equation, taking the road inclination angle, the steering strategy, and the hydropneumatic suspension characteristics into consideration. A 3-layer BP (backpropagation) neural network is applied to predict the road inclination angle and to optimize the rollover model in real-time. The number of the...

TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain

and prepared Fig. 1A and Fig. 1B. Dr. Wei Zeng, Xia Lin and Yuanxin Zhu participated in cell cuture and cell cycle synchronization. All authors reviewed the manuscript. Additional Information

Ground-state cooling of a mechanical oscillator in a hybrid optomechanical system including an atomic ensemble

We investigate dynamical properties and the ground-state cooling of a mechanical oscillator in an optomechanical system coupling with an atomic ensemble. In this hybrid optomechanical system, an atomic ensemble which consists of two-level atoms couples with the cavity field. Here we consider the case where the atomic ensemble is in higher excitation. Studies show that the atom...

Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells

An increase in the osmolarity of tears induced by excessive evaporation of the aqueous tear phase is a major pathological mechanism behind dry eye. Exposure of epithelial cells on the surface of the human eye to hyperosmolarity leads to oxidative stress, mitochondrial dysfunction, and apoptosis. Edaravone, a hydroxyl radical scavenging agent, is clinically used to reduce neuronal...

Production of poly-γ-glutamic acid by a thermotolerant glutamate-independent strain and comparative analysis of the glutamate dependent difference

Poly-γ-glutamic acid (γ-PGA) is a promising microbial polymer with wide applications in industry, agriculture and medicine. In this study, a novel glutamate-independent γ-PGA producing strain with thermotolerant characteristics was isolated and identified as Bacillus subtilis GXG-5, then its product was also characterized. The fermentation process was optimized by single-factor...

Uncovering the essential links in online commercial networks

Recommender systems are designed to effectively support individuals' decision-making process on various web sites. It can be naturally represented by a user-object bipartite network, where a link indicates that a user has collected an object. Recently, research on the information backbone has attracted researchers' interests, which is a sub-network with fewer nodes and links but...

PR-Index: Using the h-Index and PageRank for Determining True Impact

Several technical indicators have been proposed to assess the impact of authors and institutions. Here, we combine the h-index and the PageRank algorithm to do away with some of the individual limitations of these two indices. Most importantly, we aim to take into account value differences between citations-evaluating the citation sources by defining the h-index using the...

MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping

Purpose Approximately 3% of lung cancer bears mutations leading to MET exon 14 skipping, an oncogenic driver which is further evidenced by case reports of patient response to MET kinase inhibitor treatment. Approximately 15% of tumors harboring MET exon14 skipping have concurrent MET amplification. Experimental Design Merestinib is a type II MET kinase inhibitor. Emibetuzumab, a...

Transient Simulations in Hydropower Stations Based on a Novel Turbine Boundary

part of programming work and conducted part of case studies and discussions; Chao Wang performed part of programming work and gave technical support; Wei Zeng performed the model test and polished the

Transient Simulations in Hydropower Stations Based on a Novel Turbine Boundary

part of programming work and conducted part of case studies and discussions; Chao Wang performed part of programming work and gave technical support; Wei Zeng performed the model test and polished the

P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia

, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng Department of Physiology, Zunyi Medical College, Guizhou, China *These authors contributed equally to this work Objective: P2 receptors have been implicated

Flocking Control of Multiple Mobile Agents with the Rules of Avoiding Collision

This paper investigates the flocking and the coordinative control problems of multiple mobile agents with the rules of avoiding collision. We propose a set of control laws using hysteresis in adding new links and applying new potential function to guarantee that the fragmentation of the network can be avoided, under which all agents approach a common velocity vector, and...

A numerical framework for interstitial fluid pressure imaging in poroelastic MRE

A numerical framework for interstitial fluid pressure imaging (IFPI) in biphasic materials is investigated based on three-dimensional nonlinear finite element poroelastic inversion. The objective is to reconstruct the time-harmonic pore-pressure field from tissue excitation in addition to the elastic parameters commonly associated with magnetic resonance elastography (MRE). The...

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Dynamics of three MET antibody constructs (IgG1, IgG2, and IgG4) and the IgG4-MET antigen complex was investigated by creating their atomic models with an integrative experimental and computational approach. In particular, we used two-dimensional (2D) Electron Microscopy (EM) images, image class averaging, homology modeling, Rapidly exploring Random Tree (RRT) structure sampling...