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18 papers found.
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Application of transthoracic echocardiography in patients receiving intermediate- or high-risk noncardiac surgery

information S1 Dataset. Pre-operative echocardiography study raw data. (XLSX) Author Contributions Conceptualization: Yen-Wen Liu. Data curation: Hsien-Yuan Chang, Wei-Ting Chang. Formal analysis: Hsien ... -Yuan Chang. Investigation: Hsien-Yuan Chang. Methodology: Hsien-Yuan Chang, Yen-Wen Liu. Supervision: Wei-Ting Chang, Yen-Wen Liu. Validation: Yen-Wen Liu. Writing ? original draft: Hsien-Yuan Chang

Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): from bedside to bench

Background Despite the known risk of diabetes-induced cardiac fibrosis, less is known about whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Peroxisome proliferator-activated receptor δ (PPARδ), a versatile regulator of metabolic homeostasis, may be a potential therapeutic target. Herein we investigated the effectiveness of telmisartan...

The association between right ventricular free wall strain and exercise capacity for health check-up subjects

Background Right ventricular (RV) function has been found to be a major factor of exercise capacity in patients with heart failure. However, the role of RV function in exercise capacity in healthy subjects has not been well studied. This study aims to validate the role of RV strain derived from speckle tracking echocardiography for exercise capacity for health check-up subjects...

Interplay of Aging and Hypertension in Cardiac Remodeling: A Mathematical Geometric Model

Hypertensive disorder can cause cardiac deformities. Elastic characteristic parameters, like Young’s modulus of elasticity (E) derived from a traditional cylindrical model, increase significantly with aging. However, the geometric and component changes of aging hearts because of chronic hypertension remain unknown. To better describe the effects, we propose an elliptical elastic...

Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy

, TaiwanPo-Wei Chen, Jia-Rong Yu & Ping-Yen LiuGraduate Institute of Clinical Medical Sciences, College of Medicine, China Medical University, Taichung, TaiwanPing-Yen Liu AuthorsSearch for Wei-Ting Chang

The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis

Background Trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. The aggregation of this protozoan tends to destroy epithelial cells and induce pathogenesis. Principal Findings This study cultured T. vaginalis and human cervical epithelial...

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

Background The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of patient’s DCs for T-cell priming and the associated process...

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

The tumor cell lysate-pulsed, dendritic cell (DC)-based cancer vaccine approaches are being actively evaluated for application to cancer immunotherapy, hopefully at a personalized medicine base. There is apparently an emerging technical problem however, the lack of highly efficacious potency in activation of patient’s DCs for T-cell priming and the associated process for...

Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasis

Dendritic cell (DC) vaccines are a newly emerging immunotherapeutic approach for the treatment and prevention of cancer, but major challenges still remain particularly with respect to clinical efficacy. Engineering and optimization of adjuvant formulations for DC-based vaccines is one strategy through which more efficacious treatments may be obtained. In this study, we developed...

Characterization of Aging-Associated Cardiac Diastolic Dysfunction

Aims Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between and wedge pressure. Methods and Results We enrolled 919...

Fetuin-A as a predicator of sarcopenic left ventricular dysfunction

, College of Medicine, National Cheng Kung University Hospital, Tainan, TaiwanChih-Hsing WuCollege of Medicine, National Cheng Kung University, Tainan, TaiwanYen-Wei Lee AuthorsSearch for Wei-Ting Chang

Identifying Early Changes in Myocardial Microstructure in Hypertensive Heart Disease

The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations in the orientation and integrity of myocardial fibers can be assessed using advanced ultrasonic image analysis. We used a modified algorithm to investigate left ventricular myocardial...

The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: the Tianliao Old People (TOP) study 03

Background Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard...

Specific Dioscorea Phytoextracts Enhance Potency of TCL-Loaded DC-Based Cancer Vaccines

Benoît Nguelefack Copyright © 2013 Wei-Ting Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

A simple method using PyrosequencingTM to identify de novo SNPs in pooled DNA samples

A practical way to reduce the cost of surveying single-nucleotide polymorphism (SNP) in a large number of individuals is to measure the allele frequencies in pooled DNA samples. PyrosequencingTM has been frequently used for this application because signals generated by this approach are proportional to the amount of DNA templates. The PyrosequencingTM pyrogram is determined by...

Preparation of Nanoporous Polymer Films for Real-Time Viability Monitoring of Cells

We have demonstrated an alternative way to monitor the viability of cells adhered on a nanoporous polymer film in real time. The nanoporous polymer films were prepared by laser interference pattering. During exposure of holographic patterning, the dissolved solvents were phase separated with photocured polymer and the nanopores were created as the solvents evaporated. The...

Preparation of Nanoporous Polymer Films for Real-Time Viability Monitoring of Cells

,2 Wei-Ting Chang,3 Chang-Tze Ricky Yu,2 and Vincent K. S. Hsiao2 1Division of Pediatric Surgery, Department of Surgery, Taichung Veterans General Hospital, 160 Section 3 Chung-Kang Road, Taichung

Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines

Background Damage-associated molecular patterns (DAMPs) are associated with immunogenic cell death and have the ability to enhance maturation and antigen presentation of dendritic cells (DCs). Specific microtubule-depolymerizing agents (MDAs) such as colchicine have been shown to confer anti-cancer activity and also trigger activation of DCs. Methods In this study, we evaluated...