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Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study Xiaohua Pei,1,* Shuyuan Lai,1,* Xianglan He,1 Nakimera Pearl Masembe,1 Haichuan Yuan,1 Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department...

Study of Effect of Impacting Direction on Abrasive Nanometric Cutting Process with Molecular Dynamics

Weihong Zhao 0 0 College of Mechanical and Electric Engineering, Changchun University of Science and Technology , Changchun 130022 , China Abrasive flow polishing plays an important part in modern ultra

Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

 & Weihong Zhao AuthorsSearch for Zhenzhu Yong in:Nature Research journals • PubMed • Google ScholarSearch for Xiaohua Pei in:Nature Research journals • PubMed • Google ScholarSearch for Bei Zhu in:Nature ... Research journals • PubMed • Google ScholarSearch for Haichuan Yuan in:Nature Research journals • PubMed • Google ScholarSearch for Weihong Zhao in:Nature Research journals • PubMed • Google Scholar

Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation

Weihong Zhao Jianqing Wu OPEN Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin superfamily, which has been implicated in the pathophysiology of the nervous system. Recently, several

Influence of erythropoietin on microvesicles derived from mesenchymal stem cells protecting renal function of chronic kidney disease

Juan He 0 Weihong Zhao 0 0 Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, Nanjing, Jiangsu 210029 , China Introduction: Mesenchymal stem

Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

 Xianzhi Ren,7 Rong Qu,6,7 Yulian Jin,6,7 Weihong Zhao,3 and Changliang Xu1,7 1National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China ... . Weihong Zhao provided guidance throughout the work. Haowei He, Xianzhi Ren, Rong Qu, and Yulian Jin analyzed the experimental data. Daliang Xu and Yang Dong gave some suggestions about how to arrange the

Differentially expressed microRNAs in bone marrow mesenchymal stem cell-derived microvesicles in young and older rats and their effect on tumor growth factor-β1-mediated epithelial-mesenchymal transition in HK2 cells

Introduction The prevalence of renal fibrosis is higher in older than in younger individuals. Through paracrine activity, bone marrow mesenchymal stem cell-derived microvesicles (BM-MSC-MVs) influence the process of renal fibrosis. Differences in microRNA (miRNA) expression of BM-MSC-MVs that correlate with the age of the subjects and the correlation between miRNA expression and...

Cloning of Interleukin-10 from African Clawed Frog (Xenopus tropicalis), with the Finding of IL-19/20 Homologue in the IL-10 Locus

Interleukin-10 (IL-10) is a pleiotropic cytokine that plays an important role in immune system. In the present study, the IL-10 gene of African clawed frog (Xenopus tropicalis) was first cloned, and its expression pattern and 3D structure were also analyzed. The frog IL-10 mRNA encoded 172 amino acids which possessed several conserved features found in IL-10s from other species...

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese Xiaoshuang Ye,1 Lu Wei,1 Xiaohua Pei,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Division of Respiration...

Reference Intervals for Serum Cystatin C and Factors Influencing Cystatin C Levels Other than Renal Function in the Elderly

Objective The present study aimed to establish reference intervals for serum cystatin C (Scys-C) stratified by stages of chronic kidney disease, explore factors influencing Scys-C and compare the performance of Scys-C with serum creatinine (Scr) in the young and elderly. Methods A total of 800 participants, 516 young (<60 years) and 284 old (≥60 years) subjects were included in...

Comparisons between the 2012 New CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) Equations and Other Four Approved Equations

Jianqing Wu 0 Weihong Zhao 0 Valquiria Bueno, UNIFESP Federal University of Sao Paulo, Brazil 0 1 Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University

Using Mathematical Algorithms to Modify Glomerular Filtration Rate Estimation Equations

Background The equations provide a rapid and low-cost method of evaluating glomerular filtration rate (GFR). Previous studies indicated that the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease-Epidemiology (CKD-EPI) and MacIsaac equations need further modification for application in Chinese population. Thus, this study was designed to modify the three...

Patterns of Biomass and Carbon Distribution across a Chronosequence of Chinese Pine (Pinus tabulaeformis) Forests

Patterns of biomass and carbon (C) storage distribution across Chinese pine (Pinus tabulaeformis) natural secondary forests are poorly documented. The objectives of this study were to examine the biomass and C pools of the major ecosystem components in a replicated age sequence of P. tabulaeformis secondary forest stands in Northern China. Within each stand, biomass of above- and...

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

Background Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also serve as a potential tumor suppressor. The aim of this study is to investigate the effects and possible mechanisms of action of klotho in human lung cancer cell...

A Meta-Analysis of Caspase 9 Polymorphisms in Promoter and Exon Sequence on Cancer Susceptibility

Background Caspases are important regulators and executioners in apoptosis pathway and have been defined as either tumor suppressors or oncogenes. Polymorphisms in promoter and exon of caspase 9 were shown to confer genetic susceptibility to multiple cancers, but the results were inconsistent. To accomplish a more precise estimation of the relationship, a meta-analysis was...

Improved Glomerular Filtration Rate Estimation by an Artificial Neural Network

Background Accurate evaluation of glomerular filtration rates (GFRs) is of critical importance in clinical practice. A previous study showed that models based on artificial neural networks (ANNs) could achieve a better performance than traditional equations. However, large-sample cross-sectional surveys have not resolved questions about ANN performance. Methods A total of 1,180...

cDNA Cloning and Expression Analysis of Gustavus Gene in the Oriental River Prawn Macrobrachium nipponense

The gustavus gene is required for localizing pole plasm and specifying germ cells. Research on gustavus gene expression will advance our understanding of the biological function of gustavus in animals. A cDNA encoding gustavus protein was identified and termed MnGus in the oriental river prawn Macrobrachium nipponense. Bioinformatic analyses showed that this gene encoded a...

Klotho Sensitizes Human Lung Cancer Cell Line to Cisplatin via PI3k/Akt Pathway

Klotho was first identified in 1997 and has been considered as an anti-aging gene. Emerging evidence demonstrates that klotho has a close relationship with cancers, including lung cancer, breast cancer, etc, by inhibiting the proliferation and promoting apoptosis of cancer cells. Cisplatin has been the most widely used drug in the first-line chemotherapy. However, the increase in...

Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis

Weihong Zhao 0 Jianqing Wu 0 Amanda Ewart Toland, Ohio State University Medical Center, United States of America 0 1 Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University

IGF-I and IGFBP-3 and the risk of lung cancer: A meta-analysis based on nested case-control studies

Background Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor growth, respectively. However, there are many different results about their function in some recent epidemiological studies. To evaluate the relationship between...