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Pigment Epithelium-Derived Factor Plays a Role in Alzheimer’s Disease by Negatively Regulating Aβ42

as well as a major therapeutic target of AD [2, Mao Huang and Weiwei Qi contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007

High-efficiency CRISPR/Cas9 multiplex gene editing using the glycine tRNA-processing system-based strategy in maize

Background CRISPR/Cas9 genome editing strategy has been applied to a variety of species and the tRNA-processing system has been used to compact multiple gRNAs into one synthetic gene for manipulating multiple genes in rice. Results We optimized and introduced the multiplex gene editing strategy based on the tRNA-processing system into maize. Maize glycine-tRNA was selected to...

Research on Safety and Static-Dynamic Legibility of Distressed Pavement

In order to study the impacts of distressed pavement on driving safety, the drivers’ driving behavior and driving characteristics need to be analyzed. By analyzing the drivers’ characteristics, driving behavior’ and braking characteristics of vehicles, relation between static legibility distance of the distressed pavement under different driving conditions and dynamic legibility...

Game Theory Model of Traffic Participants within Amber Time at Signalized Intersection

Engineering, Zhejiang Traffic Technician College, Jinhua 321000, China Received 10 October 2014; Accepted 26 November 2014; Published 15 December 2014 Academic Editor: Yongjun Shen Copyright © 2014 Weiwei ... Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original

IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang Obesity and associated metabolic diseases are characterized by a

Pattern Analysis of Driver’s “Pressure-State-Response” in Traffic Congestion

, China Received 25 September 2013; Revised 4 November 2013; Accepted 10 November 2013 Academic Editor: Huimin Niu Copyright © 2013 Weiwei Qi et al. This is an open access article distributed under the

Pattern Analysis of Driver’s “Pressure-State-Response” in Traffic Congestion

, China Received 25 September 2013; Revised 4 November 2013; Accepted 10 November 2013 Academic Editor: Huimin Niu Copyright © 2013 Weiwei Qi et al. This is an open access article distributed under the

Reconstruction Method for Nonconcyclic Dual-Source Circular Cone-Beam CT with a Large Field of View

In industrial computed tomography (CT), it is often required to inspect large objects whose size is beyond a reconstructed field of view (FOV). Some multiscan modes have been developed to acquire the complete CT projection data for a larger object using small panel detectors. In this paper, we give a non-concyclic dual-source circular cone-beam scanning geometry based on the idea...

Telomerase: A Target for Therapeutic Effects of Curcumin and a Curcumin Derivative in Aβ1-42 Insult In Vitro

This study was designed to investigate whether telomerase was involved in the neuroprotective effect of curcumin and Cur1. Alzheimer's disease is a consequence of an imbalance between the generation and clearance of amyloid-beta peptide in the brain. In this study, we used Aβ1-42 (10 µg/ml) to establish a damaged cell model, and curcumin and Cur1 were used in treatment groups. We...

Diabetes - Experimental

Introduction and Aims: Obesity is one of major health problem, which is related to the metabolic syndrome. The metabolic syndrome is characterized by insulin resistance, dyslipidemia and hypertension. These metabolic changes contribute to the development of obesity-induced kidney injury, which is characterized glomerular hypertrophy, thickening of the glomerular basement membrane...