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Application of transthoracic echocardiography in patients receiving intermediate- or high-risk noncardiac surgery

information S1 Dataset. Pre-operative echocardiography study raw data. (XLSX) Author Contributions Conceptualization: Yen-Wen Liu. Data curation: Hsien-Yuan Chang, Wei-Ting Chang. Formal analysis: Hsien ... -Yuan Chang. Investigation: Hsien-Yuan Chang. Methodology: Hsien-Yuan Chang, Yen-Wen Liu. Supervision: Wei-Ting Chang, Yen-Wen Liu. Validation: Yen-Wen Liu. Writing ? original draft: Hsien-Yuan Chang

Chlorella diet alters mitochondrial cardiolipin contents differentially in organs of Danio rerio analyzed by a lipidomics approach

(SAS-MOST JRP 2016/4) to MB. We would like to thank Hsin-Yu Hou for the maintenance of the zebrafish stock. Author Contributions Conceptualization: Yi-Wen Liu, Yuan-Hao Howard Hsu. Data curation: Yu ... -Jen Chao, Maria Balazova, Ting-Yuan Wu, Jamie Lin, Yi-Wen Liu, Yuan Hao Howard Hsu. Formal analysis: Wen-Hsin Wu, Maria Balazova, Yuan-Hao Howard Hsu. Funding acquisition: Maria Balazova, Yi-Wen Liu

The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice

-Hsein Chen, Yi-Wen Liu. Data curation: Mohammad Mezbahul Haque, Wei-Han Lin, Yi-Wen Liu. Formal analysis: Yuan-Chang Dai, Yi-Wen Liu. Funding acquisition: Shou-Chieh Wang. Investigation: Yuan-Chang ... Dai, Shou-Chieh Wang, Yi-Wen Liu. Methodology: Yuan-Chang Dai, Lei-Chen Lin. Supervision: Ching-Hsein Chen, Yi-Wen Liu. Writing ± original draft: Yi-Wen Liu. Writing ± review & editing: Yuan-Chang

The association between right ventricular free wall strain and exercise capacity for health check-up subjects

Background Right ventricular (RV) function has been found to be a major factor of exercise capacity in patients with heart failure. However, the role of RV function in exercise capacity in healthy subjects has not been well studied. This study aims to validate the role of RV strain derived from speckle tracking echocardiography for exercise capacity for health check-up subjects...

Engineering Properties and Microstructural Performance of Low Energy Super-Sulfated Cement Using Industrial Waste Anhydrite

Chun-Tao Chen Yu-Wen Liu 0 0 Department of Civil and Water Resources Engineering, National Chiayi University , Chiayi , Taiwan This study aims at proposing the mix proportions of low energy super

Engineering Properties and Microstructural Performance of Low Energy Super-Sulfated Cement Using Industrial Waste Anhydrite

Chun-Tao Chen Yu-Wen Liu 0 0 Department of Civil and Water Resources Engineering, National Chiayi University , Chiayi , Taiwan This study aims at proposing the mix proportions of low energy super

Combining MAD and CPAP as an effective strategy for treating patients with severe sleep apnea intolerant to high-pressure PAP and unresponsive to MAD

Lee. Data curation: Hsiang-Wen Liu, Yunn-Jy Chen, Yi-Chun Lai, Ching-Yi Huang, Ya-Ling Huang, Sung-Ying Han, Chong-Jen Yu, Pei-Lin Lee. Formal analysis: Hsiang-Wen Liu, Ya-Ling Huang, Ming-Tzer Lin ... . Supervision: Yunn-Jy Chen, Chong-Jen Yu, Pei-Lin Lee. Validation: Yunn-Jy Chen, Pei-Lin Lee. Writing ± original draft: Hsiang-Wen Liu, Yi-Chun Lai. Writing ± review & editing: Pei-Lin Lee. 12 / 14 Randomized

Vertebral artery terminating in posterior inferior cerebellar artery: A normal variation with clinical significance

A vertebral artery (VA) terminating in a posterior inferior cerebellar artery (PICA) is often considered to be a normal variation associated with VA hypoplasia. We aimed to investigate the clinical significance of this cerebrovascular variant. A total of 80 patients with clinically evident cerebrovascular events in posterior circulation were examined by duplex sonography and...

Prognostic impact of restored sinus rhythm in patients with sepsis and new-onset atrial fibrillation

Background New-onset atrial fibrillation (NeOAF) is a common type of tachyarrhythmia in critically ill patients and is associated with increased mortality in patients with sepsis. However, the prognostic impact of restored sinus rhythm (SR) in septic patients with NeOAF remains unclear. Methods A total of 791 patients with sepsis, who were admitted to a medical intensive care...

Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may...

Gene Expression and DNA Methylation Status of Glutathione S-Transferase Mu1 and Mu5 in Urothelial Carcinoma

Bladder cancer is highly recurrent after therapy, which has an enormous impact on the health and financial condition of the patient. It is worth developing diagnostic tools for bladder cancer. In our previous study, we found that the bladder carcinogen BBN increased urothelial global DNA CpG methylation and decreased GSTM1 protein expression in mice. Here, the correlation of BBN...

Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

Background Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, cell cycle arrest and apoptosis induction in several cancer cell lines. However, the biological functions and molecular mechanisms of mammalian cells under SSd...

The Hemodynamically-Regulated Vascular Microenvironment Promotes Migration of the Steroidogenic Tissue during Its Interaction with Chromaffin Cells in the Zebrafish Embryo

Background While the endothelium-organ interaction is critical for regulating cellular behaviors during development and disease, the role of blood flow in these processes is only partially understood. The dorsal aorta performs paracrine functions for the timely migration and differentiation of the sympatho-adrenal system. However, it is unclear how the adrenal cortex and medulla...

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

Methadone maintenance treatment (MMT) is commonly used for controlling opioid dependence, preventing withdrawal symptoms, and improving the quality of life of heroin-dependent patients. A steady-state plasma concentration of methadone enantiomers, a measure of methadone metabolism, is an index of treatment response and efficacy of MMT. Although the methadone metabolism pathway...

Tumor necrosis factor-alpha induces VCAM-1-mediated inflammation via c-Src-dependent transactivation of EGF receptors in human cardiac fibroblasts

Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and elevated in the regions of tissue injury and inflammatory diseases. The deleterious effects of TNF-α on fibroblasts may aggravate heart inflammation mediated through the up-regulation of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1). However, the mechanisms underlying TNF...

Mechanism of action of the flippase Drs2p in modulating GTP hydrolysis of Arl1p

Small GTPase ADP-ribosylation factors (ARFs) are key regulators of membrane trafficking and their activities are determined by guanine-nucleotide-binding status. In Saccharomyces cerevisiae, Arl1p, an ARF-like protein, is responsible for multiple trafficking pathways at the Golgi. The GTP-hydrolysis activity of Arl1p is stimulated by its GTPase-activating protein Gcs1p, and...

TNF-α Mediates PKCδ/JNK1/2/c-Jun-Dependent Monocyte Adhesion via ICAM-1 Induction in Human Retinal Pigment Epithelial Cells

Retinal inflammatory diseases induced by cytokines, such as tumor necrosis factor-α (TNF-α) are associated with an up-regulation of intercellular adhesion molecule-1 (ICAM-1) in the retinal pigment epithelial cells (RPECs). Retinal pigment epithelium (RPE) is a monolayer of epithelial cells that forms the outer blood-retinal barrier in the posterior segment of the eye, and is...

Development and Fibronectin Signaling Requirements of the Zebrafish Interrenal Vessel

Background The early morphogenetic steps of zebrafish interrenal tissue, the teleostean counterpart of the mammalian adrenal gland, are modulated by the peri-interrenal angioblasts and blood vessels. While an organized distribution of intra-adrenal vessels and extracellular matrix is essential for the fetal adrenal cortex remodeling, whether and how an intra-interrenal buildup of...

Shoe Sole Tread Designs and Outcomes of Slipping and Falling on Slippery Floor Surfaces

A gait experiment was conducted under two shoe sole and three floor conditions. The shoe soles and floors were characterized by the tread and groove designs on the surface. The coefficients of friction (COF) on the floor in the target area were measured. The subjects were required to walk on a walkway and stepping on a target area covered with glycerol. The motions of the feet of...