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243 papers found.
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Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities

major experiments; Xiao-fang LIU, Yang YANG, Yu-bo ing will be helpful and valuable for further functional studies TANG, and Kai-wen LIU participated in the construction of of CD97, especially for studies

Effects of propofol on ischemia-induced ventricular arrhythmias and mitochondrial ATP-sensitive potassium channels

study design and for writing the paper. Data analysis was conducted by Xiao-yu LI and Cheng QIAN. Qiang LIU and Rong CHEN conducted the experiments. Jun-yan YAO, Longsheng SONG, Shao-wen LIU and Bao-gui

Propofol and arrhythmias: two sides of the coin

The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supraventricular tachycardia and ventricular tachycardia and may...

4′-Chloro-3,5-dihydroxystilbene, a resveratrol derivative, induces lung cancer cell death

-jing CHUANG 3 Yi-wen LIU 0 0 Graduate Institute of Biomedical and Biopharmaceutical Sciences 1 Department of Internal Medicine, Buddhist Tzuchi Dalin General Hospital , Dalin Town, Chiayi , Taiwan 62247 ... . Acknowledgements This work was supported by grants from the National Science Council of Taiwan (NSC97-2320-B-415-002) and the Buddhist Tzuchi Dalin General Hospital (DTCRD97(2)-08). Author contribution Yi-wen LIU

Gum mastic increases maspin expression in prostate cancer cells

Aim:To study whether gum mastic, a natural resin, can regulate maspin expression in prostate cancer cells, and further investigate the mechanisms involved in this regulatory system.Methods:RT-PCR and Western blotting were used to detect maspin expression at the transcriptional and translational levels. Reporter gene assay was used to investigate the effect of gum mastic on the...

A Low-Pass Filter of Wide Stopband with a Novel Multilayer Fractal Photonic Bandgap Structure

A novel, multilayer fractal PBG is presented here as the substrate for a microstrip line and the resulting configuration builds a low-pass filter of wide stopband. Experimental results in comparison with the corresponding two filters with monolayer PBG show that the proposed filter drastically enhances the width of the stopband.

A Low-Pass Filter of Wide Stopband with a Novel Multilayer Fractal Photonic Bandgap Structure

A novel, multilayer fractal PBG is presented here as the substrate for a microstrip line and the resulting configuration builds a low-pass filter of wide stopband. Experimental results in comparison with the corresponding two filters with monolayer PBG show that the proposed filter drastically enhances the width of the stopband.

The Last Mile: Safety Management Implementation in Construction Sites

To deepen the understanding of the construction safety accidents rules as well as identify and cure the crux of construction safety management failures in China, we analyzed the status quo of safety management and identified the “last mile” problem, that is, the failure of implementation of the extensive legal and regulatory systems on the construction site. The safety factors...

Effects of Water Inrush from Tunnel Excavation Face on the Deformation and Mechanical Performance of Shield Tunnel Segment Joints

Water inrush from the excavation face often occurs in the current shield construction of metro tunnels. In this study, the discontinuity of shield tunnel lining and the interaction between the tunnel segments, the grouting layer, and the surrounding rock are considered. Based on the 3D nonlinear contact theory, a hybrid model of the shield tunnel is constructed. Considering the...

Effects of Water Inrush from Tunnel Excavation Face on the Deformation and Mechanical Performance of Shield Tunnel Segment Joints

Water inrush from the excavation face often occurs in the current shield construction of metro tunnels. In this study, the discontinuity of shield tunnel lining and the interaction between the tunnel segments, the grouting layer, and the surrounding rock are considered. Based on the 3D nonlinear contact theory, a hybrid model of the shield tunnel is constructed. Considering the...

Evaluation of an Improved Technique for Geosynthetic-Reinforced and Pile-Supported Embankment

With a large number of applications of conventional technique for geosynthetic-reinforced and pile-supported (GRPS) embankment (called CT embankment), many deficiencies have been exposed. In view of the deficiencies, an improved technique, fixed-geosynthetic-reinforced and pile-supported embankment (called FGT embankment), is developed. To investigate the performance of the FGT...

Characterization of clinical extensively drug-resistant Pseudomonas aeruginosa in the Hunan province of China

Background Pseudomonas aeruginosa strains that are classed as extensively drug resistant (XDR-PA) are resistant to all antibiotics except for one or two classes and are frequently the cause of hard-to-treat infections worldwide. Our study aimed to characterize clinical XDR-PA isolates recovered during 2011–2012 at nine hospitals in the Hunan province of China. Methods Thirty...

Quantitative prediction of mouse class I MHC peptide binding affinity using support vector machine regression (SVR) models

Background The binding between peptide epitopes and major histocompatibility complex proteins (MHCs) is an important event in the cellular immune response. Accurate prediction of the binding between short peptides and the MHC molecules has long been a principal challenge for immunoinformatics. Recently, the modeling of MHC-peptide binding has come to emphasize quantitative...

SVRMHC prediction server for MHC-binding peptides

Background The binding between antigenic peptides (epitopes) and the MHC molecule is a key step in the cellular immune response. Accurate in silico prediction of epitope-MHC binding affinity can greatly expedite epitope screening by reducing costs and experimental effort. Results Recently, we demonstrated the appealing performance of SVRMHC, an SVR-based quantitative modeling...

Clinicopathologic characteristics and prognostic factors for primary spinal epidural lymphoma: report on 36 Chinese patients and review of the literature

Background Due to the uncommon nature of primary spinal epidural lymphomas (PSELs), there has been little research looking at prognostic indicators for the tumor. To our knowledge, this is the largest study to evaluate possible clinical and pathologic prognostic factors in PSEL patients. Methods We retrospectively reviewed 130 cases of PSEL, including 36 Chinese patients and 94...

Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

Background Saikosaponin d (SSd) is one of the main active triterpene saponins in Bupleurum falcatum. It has a steroid-like structure, and is reported to have pharmacological activities, including liver protection in rat, cell cycle arrest and apoptosis induction in several cancer cell lines. However, the biological functions and molecular mechanisms of mammalian cells under SSd...

Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

Background In South and Southeast Asian, the majority of buccal squamous cell carcinoma (BSCC) can arise from oral submucous fibrosis (OSF). BSCCs develop in OSF that are often not completely resected, causing local relapse. The aim of our study was to find candidate protein biomarkers to detect OSF and predict prognosis in BSCCs by quantitative proteomics approaches. Methods We...

Analysis of the impact of platinum-based combination chemotherapy in small cell cervical carcinoma: a multicenter retrospective study in Chinese patients

Background Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study was to establish whether platinum-based combination chemotherapy may by beneficial in this patient population. Methods We carried out a multicenter...

Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

Background Gastric cancer is the second leading cause of cancer death and remains a major clinical challenge due to poor prognosis and limited treatment options. Long noncoding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, and potential therapeutic targets. Although downregulation of lncRNA GAS5 (Growth...