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19 papers found.
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The association of infrared imaging findings of the breast with prognosis in breast cancer patients: an observational cohort study

Background To evaluate whether infrared (IR) imaging findings are associated with prognosis in patients with invasive breast carcinomas. Methods This study was approved by the institutional review board of the research ethics committee of our hospital, and all participants gave written informed consent. From March 2005 to June 2007, we enrolled 143 patients with invasive breast...

Small-window parametric imaging based on information entropy for ultrasound tissue characterization

Constructing ultrasound statistical parametric images by using a sliding window is a widely adopted strategy for characterizing tissues. Deficiency in spatial resolution, the appearance of boundary artifacts, and the prerequisite data distribution limit the practicability of statistical parametric imaging. In this study, small-window entropy parametric imaging was proposed to...

Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate

-Hwa Lee AuthorsSearch for Chun-Kai Huang in:Nature Research journals • PubMed • Google ScholarSearch for Po-Hao Chang in:Nature Research journals • PubMed • Google ScholarSearch for Wen-Hung Kuo

Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway

• PubMed • Google Scholar Search for Wen-Hung Kuo in:Nature Research journals • PubMed • Google Scholar Search for Chiao-Mei Lin in:Nature Research journals • PubMed • Google Scholar Search for Wen-Ling

The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas

Background. Gene expression profiles of 181 breast cancer samples were analyzed to identify prognostic features of nuclear receptors NR5A1 and NR5A2 based upon their associated transcriptional networks. Methods. A supervised network analysis approach was used to build the NR5A-mediated transcriptional regulatory network. Other bioinformatic tools and statistical methods were...

Classification of Benign and Malignant Breast Tumors in Ultrasound Images with Posterior Acoustic Shadowing Using Half-Contour Features

Posterior acoustic shadowing (PAS) can bias breast tumor segmentation and classification in ultrasound images. In this paper, half-contour features are proposed to classify benign and malignant breast tumors with PAS, considering the fact that the upper half of the tumor contour is less affected by PAS. Adaptive thresholding and disk expansion are employed to detect tumor...

A Supervised Network Analysis on Gene Expression Profiles of Breast Tumors Predicts a 41-Gene Prognostic Signature of the Transcription Factor MYB across Molecular Subtypes

Chang,2 Wen-Hung Kuo,3 Hsiao-Lin Hwa,2 King-Jen Chang,3,4 and Fon-Jou Hsieh2,5 1Biometry Division, Department of Agronomy, National Taiwan University, Taipei 106, Taiwan 2Department of Obstetrics and ... prepared illustrations, figures, and tables for this paper. Wen-Hung Kuo collected and confirmed survival data of 181 patients for this study. Li-Yun Chang designed the study, performed Venn diagram analyses

A Supervised Network Analysis on Gene Expression Profiles of Breast Tumors Predicts a 41-Gene Prognostic Signature of the Transcription Factor MYB across Molecular Subtypes

Chang,2 Wen-Hung Kuo,3 Hsiao-Lin Hwa,2 King-Jen Chang,3,4 and Fon-Jou Hsieh2,5 1Biometry Division, Department of Agronomy, National Taiwan University, Taipei 106, Taiwan 2Department of Obstetrics and ... prepared illustrations, figures, and tables for this paper. Wen-Hung Kuo collected and confirmed survival data of 181 patients for this study. Li-Yun Chang designed the study, performed Venn diagram analyses

Safety and Efficacy of Tien-Hsien Liquid Practical in Patients with Refractory Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase IIa Trial

To evaluate the safety and efficacy of Tien-Hsien Liquid Practical (THL-P), a Chinese herbal mixture, in patients with refractory metastatic breast cancer, we performed a randomized, double-blind, placebo-controlled, parallel-group, phase IIa pilot trial. Patients were randomly assigned to either receive THL-P or matching placebo and followed up every 4 weeks for 24 weeks. The...

Safety and Efficacy of Tien-Hsien Liquid Practical in Patients with Refractory Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase IIa Trial

: Wolfgang Weidenhammer Copyright © 2012 Wen-Hung Kuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas

Background Triple-negative breast cancer is a subtype of breast cancer with aggressive tumor behavior and distinct disease etiology. Due to the lack of an effective targeted medicine, treatment options for triple-negative breast cancer are few and recurrence rates are high. Although various multi-gene prognostic markers have been proposed for the prediction of breast cancer...

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

Background MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast cancer that does not express the genes for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are still poorly understood...

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

data were uploaded to the Gene Expression Omnibus (GEO) with an accession number of GSE40049. Notes Yao-Yin Chang and Wen-Hung Kuo contributed equally to this work. Abbreviations miRNA:  MicroRNA

High Prevalence of the BIM Deletion Polymorphism in Young Female Breast Cancer in an East Asian Country

Background A rapid surge of female breast cancer has been observed in young women in several East Asian countries. The BIM deletion polymorphism, which confers cell resistance to apoptosis, was recently found exclusively in East Asian people with prevalence rate of 12%. We aimed to evaluate the possible role of this genetic alteration in carcinogenesis of breast cancer in East...

Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

Microenvironment plays an important role in cancer development. We have reported that the cancer-associated stromal cells exhibit phenotypic and functional changes compared to stromal cells neighboring to normal tissues. However, the molecular mechanisms as well as the maintenance of these changes remain elusive. Here we showed that through co-culture with breast cancer cells for...

Identification of Prognostic Genes for Recurrent Risk Prediction in Triple Negative Breast Cancer Patients in Taiwan

Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study is to construct a prediction model for recurrence of triple negative breast cancer in Taiwanese patients. Whole genome...

Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

It has been well documented that microenvironment consisting of stroma affects breast cancer progression. However, the mechanisms by which cancer cells and fibroblasts, the major cell type in stroma, interact with each other during tumor development remains to be elucidated. Here, we show that the human cancer-associated fibroblasts (CAFs) had higher activity in enhancing breast...

Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers

Heterogeneity of cancer stem/progenitor cells that give rise to different forms of cancer has been well demonstrated for leukemia. However, this fundamental concept has yet to be established for solid tumors including breast cancer. In this communication, we analyzed solid tumor cancer stem cell markers in human breast cancer cell lines and primary specimens using flow cytometry...

Statistical identification of gene association by CID in application of constructing ER regulatory network

Han S Lee 7 Tzu L Phang 6 Li-Yun Chang 5 Wen-Hung Kuo 4 Hsiao- Lin Hwa 5 Huang-Chun Lien 9 Shih-Ming Jung 8 Yi-Shing Lin 2 King- Jen Chang 4 Fon-Jou Hsieh 5 10 11 0 Graduate Institute of