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H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

Scholar Search for Zhihong Yang in:Nature Research journals • PubMed • Google Scholar Search for Wendong Huang in:Nature Research journals • PubMed • Google Scholar Search for Jianguo Wu in:Nature

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Vertical sleeve gastrectomy (VSG) produces sustainable weight loss, remission of type 2 diabetes (T2D), and improvement of nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying the metabolic benefits of VSG have remained elusive. According to our previous results, diet-induced obesity induces epigenetic modifications to chromatin in mouse liver...

Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis

Various drugs have been developed to treat obesity, but these have undesirable secondary effects, and an efficient but non-toxic anti-obesity drug from natural sources is desired. This study investigated the anti-obesity effects and mechanisms of action of acetylshikonin (AS)—which is used in traditional Chinese medicine—in rats on a high-fat diet (HFD). Rats were fed a normal...

Identification of miR-26a as a Target Gene of Bile Acid Receptor GPBAR-1/TGR5

GPBAR1/TGR5 is a G protein–coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity and improving glucose regulation, however, the mechanism of which is still unclear. Here we report that TGR5 is involved in mediating the anti-obesity and anti-hyperglycemia effect...

Bile Acid Receptors and Liver Cancer

Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of cancer death in the world. Bile acids (BAs) are liver-produced amphipathic molecules that are required to facilitate the absorption of cholesterol, fat-soluble vitamins, and lipids in the intestine. However, BAs are also known to act as potential carcinogens and deregulation of BA homeostasis...

TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism

TGR5, an emerging G protein-coupled receptor, was identified as a membrane receptor for bile acids. The expression of TGR5 and its function are distinct from the previously identified nuclear bile acid receptor, farnesoid X receptor (FXR). These two bile acid receptors complement with each other for maintaining bile acid homeostasis and mediating bile acid signaling. Both...

Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib

Xiujun Cai in:Nature Research journals • PubMed • Google ScholarSearch for Wendong Huang in:Nature Research journals • PubMed • Google ScholarSearch for Weidong Han in:Nature Research journals • PubMed ... Correspondence to Xiujun Cai or Wendong Huang or Weidong Han. Supplementary information PDF files1.Supplementary Information Supplementary materials Rights and permissions This work is licensed under a

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

GPBAR1/TGR5 is a novel plasma membrane-bound G protein–coupled bile acid (BA) receptor. BAs are known to induce the expression of inflammatory cytokines in the liver with unknown mechanism. Here we show that without other external stimuli, TGR5 activation alone induced the expression of interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) in murine macrophage cell line...

The nuclear receptor CAR modulates alcohol-induced liver injury

Huang in:Nature Research journals • PubMed • Google Scholar Competing interests The authors declare no conflict of interest. Corresponding author Correspondence to Wendong Huang. Rights and permissions ... journals • PubMed • Google ScholarSearch for Xiaoqiong Wang in:Nature Research journals • PubMed • Google ScholarSearch for Samuel Zeng in:Nature Research journals • PubMed • Google ScholarSearch for Wendong

Oxaliplatin but Not Irinotecan Impairs Posthepatectomy Liver Regeneration in a Murine Model

Introduction. We examined the murine hepatectomy model of liver regeneration (LR) in the setting of neoadjuvant chemotherapy. Methods. C57BL/6 mice were randomized to receive neoadjuvant intraperitoneal (IP) injections of a control, oxaliplatin (15 mg/kg), or irinotecan (100 mg/Kg or 250 mg/Kg) solution. Hepatectomy (70%) was performed 14 days after the final IP treatment...

The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor

Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern. Our data show that NP also activates the constitutive androstane receptor (CAR), an orphan nuclear receptor important in the...