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MDM2 promoter del1518 polymorphism and cancer risk: evidence from 22,931 subjects

MDM2 promoter del1518 polymorphism and cancer risk: evidence from 22,931 subjects Wenfeng Hua,1,* Anqi Zhang,2,* Ping Duan,2,* Jinhong Zhu,3 Yuan Zhao,2 Jing He,4 Zhi Zhang1 1Department of Laboratory ... MDM2 del1518 polymorphism and cancer risk. MDM2; del1518; polymorphism; cancer susceptibility; meta-analysis - open access to scientific and medical research O r i g i n a l r e s e a r c h Wenfeng

miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo

Background Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain and infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that noncoding RNAs, including microRNAs and long noncoding RNAs, play important roles in the development of endometriosis. Methods Expression profiling of miRNAs in...

BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro

Background BRCC3 has been found to be aberrantly expressed in breast tumors and involved in DNA damage response. The contribution of BRCC3 to nasopharyngeal carcinoma prognosis and radiosensitivity is still unclear. Methods Immunohistochemical analysis of BRCC3 was carried out in 100 nasopharyngeal carcinoma tissues, and the protein level was correlated to patient survival. BRCC3...