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Standing to Sue in Another's Shoes: Can an Assignee of an Accrued Copyright Infringement Claim with No Other Interest in the Copyright Itself Sue for the Infringement?

Itself Sue for the Infringement? Wenjie Li* Introduction Congress' paramount goal in enacting the Copyright Act is to "encourage the production of original literary, artistic, and musical expression for

Digital entrepreneurship ecosystem as a new form of organizing: the case of Zhongguancun

Digital innovation is becoming increasingly important in today’s economy. Many digital innovations are developed not within organizations, but in innovation-driven entrepreneurial ecosystems, where various entrepreneurship related stakeholders collaborate and cooperate. Despite its significance, studies on digital entrepreneurship ecosystems (DEEs) are limited and the concept is...

Maternal transmission disequilibrium of rs2248359 in type 2 diabetes mellitus families and its association with vitamin D level in offspring

Zhenxing Mao Chongjian Wang Yue Ba Wenjie Li OPEN Published: xx xx xxxx Association between T2DM and vitamin D deficiency has been reported in many epidemiologic studies. 24-hydroxylase encoded by CYP24A1 ... . These results are valuable for T2DM prevention and vitamin D supplementation guidance. Author Contributions Songcheng Yu, Chongjian Wang, Yue Ba, and Wenjie Li designed research; Songcheng Yu, Xing Li

Characteristics and origin of the relatively high-quality tight reservoir in the Silurian Xiaoheba Formation in the southeastern Sichuan Basin

A mature understanding of the sandstone gas reservoir in the Xiaoheba Formation in the southeastern Sichuan Basin remains lacking. To assess the reservoir characteristics and the origin of the high-quality reservoir in the Xiaoheba Formation, this paper uses systematic field investigations, physical property analysis, thin section identification, scanning electron microscopy and...

The association between serum 25-hydroxyvitamin D3 concentration and serum lipids in the rural population of China

Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China. Face-to-face research was used to gather some...

Microstructure and Mechanical Properties of Mg/2 wt.%SiCp Nanocomposite Fabricated by ARB Process

Magnesium matrix nanocomposites (MMNC, the same below) containing 2 wt.% nanosized were fabricated through accumulative roll bonding (ARB). The microstructure and mechanical properties of Mg/2 wt.% nanocomposites are reported for various ARB cycles. To evaluate microstructure of the nanocomposites, the field emission scanning electron microscope (FE-SEM), X-ray diffractometer...

Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis

Urate oxidase is a key enzyme in purine metabolism and catalyzes the oxidation of uric acid to allantoin. It is used to treat hyperuricemia and gout, and also in a diagnostic kit. In this study, error-prone polymerase chain reaction and staggered extension process was used to generate a mutant urate oxidase with improved enzyme activity from Bacillus subtilis. After several...

Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ

Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with the Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well as tumorigenesis. Here we first show that ACTL6A is upregulated in human gliomas and its expression...

Metabolic engineering of indole pyruvic acid biosynthesis in Escherichia coli with tdiD

Background Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food industries. It also has a wide range of applications, such as drugs for the nervous system, cosmetics, and luminophores. Chemical synthesis of IPA is a complicated and costly process. Moreover, through the biosynthesis...

OsLAP6/OsPKS1, an orthologue of Arabidopsis PKSA/LAP6, is critical for proper pollen exine formation

Background Male fertility is crucial for rice yield, and the improvement of rice yield requires hybrid production that depends on male sterile lines. Although recent studies have revealed several important genes in male reproductive development, our understanding of the mechanisms of rice pollen development remains unclear. Results We identified a rice mutant oslap6 with complete...

The Description of Shale Reservoir Pore Structure Based on Method of Moments Estimation

Shale has been considered as good gas reservoir due to its abundant interior nanoscale pores. Thus, the study of the pore structure of shale is of great significance for the evaluation and development of shale oil and gas. To date, the most widely used approaches for studying the shale pore structure include image analysis, radiation and fluid invasion methods. The detailed pore...

Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells

authorship requirements. Zheyong Liang and Wenjie Li participated in the design of the study, performed the immunoassays and drafted the manuscript. Jie Liu and Juan Li participated in the study design and

Comparison and evaluation of two exome capture kits and sequencing platforms for variant calling

Background To promote the clinical application of next-generation sequencing, it is important to obtain accurate and consistent variants of target genomic regions at low cost. Ion Proton, the latest updated semiconductor-based sequencing instrument from Life Technologies, is designed to provide investigators with an inexpensive platform for human whole exome sequencing that...

Evaluating the Quality of Cardiopulmonary Resuscitation in the Emergency Department by Real-Time Video Recording System

controlled trials (RCT) with larger sample size and prospective studies of the effects of suggested measures could further enhance our knowledge in We confirm Dr. Sheng Chen, Dr. Wenjie Li and Dr. Zhonglin ... Zhang contributed equally to this work. All the authors have participated actively in the study, and have seen and approved the submitted manuscript. Dr. Sheng Chen, Dr. Wenjie Li and Dr. Zhonglin Zhang

Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion

Background LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and breast cancer progression. However, little work has been done on the roles of LKB1 in cell polarity and epithelial-mesenchymal transition in breast cancer. In...

Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62/IMP2 in Ovarian Cancer

Ovarian cancer is one of the leading causes of cancer-related deaths among women. There is an urgent need of better approaches for the identification of appropriate biomarkers in the early detection of ovarian cancer. The aim of this study was to elucidate the significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins (IMPs) in patients with...

MicroRNA-410 Reduces the Expression of Vascular Endothelial Growth Factor and Inhibits Oxygen-Induced Retinal Neovascularization

Retinal neovascularization (RNV) is an eye disease that can cause retinal detachment and even lead to blindness. RNV mainly occurs in the elderly population. The pathogenesis of RNV has been previously reported to be highly related to the expression of vascular endothelial growth factor A (VEGFA), basic fibroblast growth factor (bFGF) and other angiogenic factors. It has also...

De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway

Background The entire world is facing a deteriorating environment. Understanding the mechanisms underlying plant responses to external abiotic stresses is important for breeding stress-tolerant crops and herbages. Phytohormones play critical regulatory roles in plants in the response to external and internal cues to regulate growth and development. Medicago falcata is one of the...

CMTM3 Inhibits Human Testicular Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

Human CMTM3 has been proposed as a putative tumor suppressor gene. The loss of CMTM3 has been found in several carcinomas. However, the regulation of CMTM3 expression and its function in tumor progression remain largely unknown. Here, we investigated the regulation of CMTM3 expression, function and molecular mechanism in human testicular cancer cells. CMTM3 was frequently...

Chikungunya virus with E1-A226V mutation causing two outbreaks in 2010, Guangdong, China

Background CHIKV is a mosquito-borne emerging pathogen that has a major health impact in humans in tropical zones around the globe. A new variant of the virus, E1-A226V caused a large outbreak in the Indian Ocean islands and India from 2004–2007. CHIKV outbreak was initially reported in Dongguan region of Guangdong in 2010 in China, another smaller CHIKV outbreak was found in...