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36 papers found.
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Does lower extremity pain precede spinal pain? A longitudinal study

The main objective was to investigate whether children aged 9–15 years at baseline were more likely to experience an incident event of spinal pain after experiencing lower extremity pain. Children’s musculoskeletal pain was monitored by weekly mobile phone text message responses from parents, indicating whether the child had spinal pain, lower extremity pain, or upper extremity...

Intratumor Genetic Heterogeneity of Breast Carcinomas as Determined by Fine Needle Aspiration and TaqMan Low Density Array

Background: Gene expression profiling is thought to be an important tool in determining treatment strategies for breast cancer patients. Tissues for such analysis may at a preoperative stage be obtained, by fine needle aspiration (FNA) allowing initiation of neoadjuvant treatment. To evaluate the extent of the genetic heterogeneity within primary breast carcinomas, we examined...

Intratumor Genetic Heterogeneity of Breast Carcinomas as Determined by Fine Needle Aspiration and TaqMan Low Density Array

Background: Gene expression profiling is thought to be an important tool in determining treatment strategies for breast cancer patients. Tissues for such analysis may at a preoperative stage be obtained, by fine needle aspiration (FNA) allowing initiation of neoadjuvant treatment. To evaluate the extent of the genetic heterogeneity within primary breast carcinomas, we examined...

Dealing with foreign cultural paradigms: A systematic review on intercultural challenges of international medical graduates

. Investigation: Kerstin Michalski. Methodology: Kerstin Michalski, Martin Boeker. Project administration: Kerstin Michalski, Martin Boeker. Resources: Kerstin Michalski. Supervision: Werner Vach, Martin Boeker ... . Validation: Kerstin Michalski, Nabeel Farhan, Werner Vach, Martin Boeker. Visualization: Kerstin Michalski. Writing ± original draft: Kerstin Michalski. Writing ± review & editing: Kerstin Michalski, Werner

4000 years of human dietary evolution in central Germany, from the first farmers to the first elites

feedback on our studies. Data curation: Harald Meller. Conceptualization: Angelina MuÈnster, Harald Meller, Kurt W. Alt. Formal analysis: Angelina MuÈnster, Corina Knipper, Werner Vach. Funding ... acquisition: Harald Meller, Kurt W. Alt. Investigation: Angelina MuÈnster, BjoÈrn Schlenker, Robert Ganslmeier, Susanne Friederich, Hans-JuÈrgen DoÈhle, Werner Vach, Kurt W. Alt. Methodology: Angelina

Is serum level of CC chemokine ligand 18 a biomarker for the prediction of radiation induced lung toxicity (RILT)?

Nestle. Author Contributions Conceptualization: Eleni Gkika, Werner Vach, Sonja Adebahr, Anton Brenner, Antje Prasse, Joachim MuÈller-Quernheim, Anca-Ligia Grosu, Gernot Zissel, Ursula Nestle. Data ... curation: Eleni Gkika, Werner Vach, Sonja Adebahr, Tanja Schimeck-Jasch, Anton Brenner, Joachim MuÈller-Quernheim, Gernot Zissel, Ursula Nestle. Formal analysis: Eleni Gkika, Werner Vach, Anton Brenner

Using existing questionnaires in latent class analysis: should we use summary scores or single items as input? A methodological study using a cohort of patients with low back pain

Nielsen,1 Werner Vach,2 Peter Kent,1,3 Lise Hestbaek,1,4 Alice Kongsted1,4 1Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; 2Center for Medical

Effects of Different Analysis Strategies on Paired Associative Stimulation. A Pooled Data Analysis from Three Research Labs

Paired associative stimulation (PAS) is a widely used transcranial magnetic stimulation (TMS) paradigm to non-invasively induce synaptic plasticity in the human brain in vivo. Altered PAS-induced plasticity has been demonstrated for several diseases. However, researchers are faced with a high inter- and intra-subject variability of the PAS response. Here, we pooled original data...

Analyzing noninferiority trials: it is time for advantage deficit assessment – an observational study of published noninferiority trials

Analyzing noninferiority trials: it is time for advantage deficit assessment – an observational study of published noninferiority trials Beryl Primrose Gladstone, Werner Vach Clinical Epidemiology ... aiming to demonstrate a positive net benefit. ADA seems to be feasible in the majority of NI trials. Ber yl Primrose gladstone; Werner Vach - superior safety as a possibility. Recently, several

Nutzenbewertung bei medizinischen Maßnahmen

Nutzenbewertung bei medizinischen Manahmen Ihre R. Klar 0 W. Vach 0 0 Rudiger Klar Werner Vach Department fur Medizinische Biometrie und Medizinische Informatik, Universitat Freiburg , Freiburg

Choice of Non-Inferiority (NI) Margins Does Not Protect against Degradation of Treatment Effects on an Average – An Observational Study of Registered and Published NI Trials

Published NI Trials Beryl Primrose Gladstone 0 Werner Vach 0 Genevie`ve Chene, Institut National de la Sante et de la Recherche Medicale, France 0 Clinical Epidemiology Group, Institute of Medical Biometry

A framework to assess the impact of applying formal criteria to check clinical relevance on top of statistical significance

Werner Vach 0 Beryl Primrose Gladstone 0 0 Clinical Epidemiology , Freiburg , Germany 2013 Vach and Gladstone; licensee BioMed Central Ltd. This is an Open Access article distributed under the

Potential role of “the compensating benefit” in claiming non-inferiority

Primrose Beryl 0 Werner Vach 0 0 Institute of Medical Biometry and Medical Informatics, University Medical Center , Freiburg , Germany From 2nd Clinical Trials Methodology Conference: Methodology

Insights into the Social Structure of the PPNB Site of Kfar HaHoresh, Israel, Based on Dental Remains

One of the central questions of the transition from mobile hunter-gatherers to sedentary farming communities concerns the establishment of new social structures and group identities. Along with other important factors, such as territory, ideology or economy, biological relationships might have played a decisive role in defining social groups. We therefore systematically analyzed...

Quality of life among elderly patients undergoing transcatheter or surgical aortic valve replacement– a model-based longitudinal data analysis

Background Quality of life (QoL) measurements reported in observational studies are often biased, since patients who failed to improve are more likely to be unable to respond due to death or impairment. In order to observe the development of QoL in patients close to death, we analyzed a set of monthly QoL measurements for a cohort of elderly patients treated for aortic valve...

Age dependence of pulmonary artery blood flow measured by 4D flow cardiovascular magnetic resonance: results of a population-based study

Background It was our aim to systematically analyze pulmonary artery blood flow within different age-groups in the general population using 4D flow cardiovascular magnetic resonance (CMR) in order to provide a context for interpreting results of future studies (e.g., in pulmonary hypertension) using this technique. Methods An age-stratified sample (n = 126) of the population of...

Google Scholar as replacement for systematic literature searches: good relative recall and precision are not enough

Background Recent research indicates a high recall in Google Scholar searches for systematic reviews. These reports raised high expectations of Google Scholar as a unified and easy to use search interface. However, studies on the coverage of Google Scholar rarely used the search interface in a realistic approach but instead merely checked for the existence of gold standard...