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Work disability and its determinants in patients with pituitary tumor-related disease

IntroductionPituitary tumors may have a considerable impact on patients’ functional status, including paid employment, yet research in this area is sparse.ObjectiveTo describe work disability and its determinants in patients treated for a pituitary tumor.MethodsCross-sectional study including patients treated for a pituitary tumor in the working age (18–65 years), who completed...

Consensus-based cross-European recommendations for the identification, measurement and valuation of costs in health economic evaluations: a European Delphi study

ObjectivesDifferences between country-specific guidelines for economic evaluations complicate the execution of international economic evaluations. The aim of this study was to develop cross-European recommendations for the identification, measurement and valuation of resource use and lost productivity in economic evaluations using a Delphi procedure.MethodsA comprehensive...

Randomized trial of one-hour sodium bicarbonate vs standard periprocedural saline hydration in chronic kidney disease patients undergoing cardiovascular contrast procedures

3 Jaap F. Hamming Aart J. van der Molen Suzanne C. Cannegieter Hein Putter Wilbert B. van den Hout Inci Kilicsoy 1 Ton J. Rabelink 0 Menno V. Huisman 1 Kathrin Eller, Medizinische Universitat Graz ... J. van der Molen, Inci Kilicsoy. Formal analysis: Hein Putter, Wilbert B. van den Hout. Funding acquisition: Judith Kooiman, Yvo W. J. Sijpkens, Jaap F. Hamming, Aart J. van der Molen, Menno V

Influence of Low Back Pain and Prognostic Value of MRI in Sciatica Patients in Relation to Back Pain

Background Patients with sciatica frequently complain about associated back pain. It is not known whether there are prognostic relevant differences in Magnetic Resonance Imaging (MRI) findings between sciatica patients with and without disabling back pain. Methods The study population contained patients with sciatica who underwent a baseline MRI to assess eligibility for a...

A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography

Background Guidelines recommend saline hydration for prophylaxis of contrast-induced acute kidney injury (CI-AKI) in patients with chronic kidney disease (CKD) undergoing intravenous contrast media-enhanced CT (CE-CT). The safety and efficacy of a brief hydration protocol using sodium bicarbonate in this population is unknown. We analysed whether 1-h sodium bicarbonate hydration...

Cost-utility analysis of genetic screening in families of patients with germline MUTYH mutations

Background MUTYH associated polyposis (MAP) is an autosomal recessive inherited disorder. Carriers of bi-allelic MUTYH germline mutations have a risk of approximately 60% to develop colorectal carcinoma (CRC). In the general population about 1.5% is a heterozygous MUTYH mutation carrier. Children of MAP patients have an increased risk of inheriting two MUTYH mutations compared to...

Designing an implementation strategy to improve interprofessional shared decision making in sciatica: study protocol of the DISC study

Stefanie N Hofstede 0 Perla J Marang-van de Mheen 0 Willem JJ Assendelft Carmen LA Vleggeert-Lankamp Anne M Stiggelbout 0 Patrick CAJ Vroomen Wilbert B van den Hout 0 Thea PM Vliet Vlieland Leti van

Magnetic Resonance Imaging Interpretation in Patients with Sciatica Who Are Potential Candidates for Lumbar Disc Surgery

Background Magnetic Resonance Imaging (MRI) is considered the mainstay imaging investigation in patients suspected of lumbar disc herniations. Both imaging and clinical findings determine the final decision of surgery. The objective of this study was to assess MRI observer variation in patients with sciatica who are potential candidates for lumbar disc surgery. Methods Patients...

Cost–Utility Analysis of Short- Versus Long-Course Palliative Radiotherapy in Patients With Non–Small-Cell Lung Cancer

Background: Radiotherapy can effectively palliate the symptoms of poor-prognosis patients with non–small-cell lung cancer. However, controversy remains about whether short-course or more protracted radiotherapy schedules provide better value for the money. We conducted a societal cost–utility analysis of a Dutch multicenter randomized trial with 1-year follow-up that compared the...

Cost-Effectiveness of Internet-Based Self-Management Compared with Usual Care in Asthma

Background Effectiveness of Internet-based self-management in patients with asthma has been shown, but its cost-effectiveness is unknown. We conducted a cost-effectiveness analysis of Internet-based asthma self-management compared with usual care. Methodology and Principal Findings Cost-effectiveness analysis alongside a randomized controlled trial, with 12 months follow-up...

Single- Versus Multiple-Fraction Radiotherapy in Patients With Painful Bone Metastases: Cost–Utility Analysis Based on a Randomized Trial

, Wilbert B. van den Hout, Hanneke de Haes) and the coordinators from the participating institutes (Hendrik Martijn, Department of Radiotherapy, Catharina Hospital, Eindhoven; Bing Oei, Dr. Bernard Verbeeten