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In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study

-Wen Hsu 2 David Todem 1 Janet Osuch 0 Angela Hungerink 5 Wilfried Karmaus 4 0 Departments of Surgery and Epidemiology and Biostatistics, College of Human Medicine, Michigan State University , 909 Fee

Maternal serum but not breast milk IL-5, IL-6, and IL-13 immune markers are associated with scratching among infants

Background Scratching in infants is considered to be related to early development of eczema. Little is known about the effects of maternal immune markers on scratching among infants. The objective is to compare the risks related to maternal serum immune markers (IMs) during pregnancy and IMs in breast milk for the occurrence of scratching in infants at 6 and 12 months of age...

Dietary supplementation with radionuclide free food improves children's health following community exposure to 137 Cesium: a prospective study

Background Following the Chernobyl nuclear disaster of 1986, vast areas of Ukraine became contaminated with radionuclides. We examined health effects of school-based food intervention for children in a rural region Narodichi, Ukraine, exposed to low-level radiation through diet of locally produced foods. Until 1995, children received three daily meals with low content of...

Mercury in fish and adverse reproductive outcomes: results from South Carolina

Wilfried Karmaus John Vena Erik Svendsen 0 WJB Dorn Veteran's Affairs Medical Center , Columbia, SC , USA 1 Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South

Pathophysiological characterization of asthma transitions across adolescence

Background Adolescence is a period of change, which coincides with disease remission in a significant proportion of subjects with childhood asthma. There is incomplete understanding of the changing characteristics underlying different adolescent asthma transitions. We undertook pathophysiological characterization of transitional adolescent asthma phenotypes in a longitudinal...

Pre- and perinatal characteristics and breast milk immune markers

and Biostatistics, University of South Carolina, Columbia, South CarolinaJessica Burch, Wilfried Karmaus, Nelís Soto-Ramírez & Mitra YousefiDivision of Epidemiology, Biostatistics and Environmental ... Burch in:Nature Research journals • PubMed • Google ScholarSearch for Wilfried Karmaus in:Nature Research journals • PubMed • Google ScholarSearch for Venu Gangur in:Nature Research journals • PubMed

Effects of long-term low-level radiation exposure after the Chernobyl catastrophe on immunoglobulins in children residing in contaminated areas: prospective and cross-sectional studies

Background After the Chernobyl nuclear incident in 1986, children in the Narodichesky region, located 80 km west of the Chernobyl Power Plant, were exposed to 137Cesium (137Cs). Little is known about the effects of chronic low-level radiation on humoral immune responses in children residing in contaminated areas. Methods In four different approaches we investigated the effect of...

Maternal immune markers in serum during gestation and in breast milk and the risk of asthma-like symptoms at ages 6 and 12 months: a longitudinal study

The role of breast milk on the risk of childhood asthma is in dispute. The aim of this prospective study is to determine the relationship of immune markers in maternal serum during gestation and breast milk to asthma-like symptoms (AS) in infancy. Pregnant women were recruited in Columbia and Charleston, South Carolina. Blood (median: three weeks before delivery) and breast milk...

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

BackgroundThe prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses. The aims of this study were to use a two-stage design to identify DNA methylation levels at cytosine–phosphate–guanine (CpG) sites across the genome associated with atopy and high serum immunoglobulin E (IgE), then to replicate our findings in an...

Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity

BackgroundAsthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs, rs20541 and rs1800925, of the IL-13 gene (IL13) have been frequently associated with asthma-related lung functions. However, genetic variation alone does not fully explain asthma risk. DNA-methylation (DNA-M) is...

The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years

John W Holloway Hongmei Zhang 0 Eric Schauberger Susan Ewart Veeresh Patil Wilfried Karmaus 0 0 Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina ... and Infectious Diseases under Award Number R01 AI091905-01 (PI: Wilfried Karmaus) and R01 AI061471 (PI: Susan Ewart). The 10-year follow-up of this study was funded by National Asthma Campaign, UK

Effect of GSTM2-5 polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study

Background Genetic variation within GSTM2-5 genes may interfere with detoxification of environmental compounds, thereby having a detrimental effect on lung function following exposures such as tobacco smoke. We aim to investigate the influence of variants and associated methylation in the GSTM gene cluster with changes in lung function growth during adolescence. Methods Growth in...

Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

of Allergy and Infectious Diseases under Award Number R01 AI091905-01 (PI: Wilfried Karmaus) and R01 AI061471 (PI: Susan Ewart). The 10-year follow-up of this study was funded by National Asthma

The role of a parental history of Balkan endemic nephropathy in the occurrence of BEN: a prospective study

The role of a parental history of Balkan endemic nephropathy in the occurrence of BEN: a prospective study Kesinee Hanjangsit1, Wilfried Karmaus1, Plamen Dimitrov2, Hongmei Zhang1, Jim Burch1, Svetla Tzolova2, Vecihi Batuman3,41Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA; 2National Center of Public Health Protection, Sofia...

Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

region. Declarations Acknowledgements Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases under Award Number R01 AI091905-01 (PI: Wilfried ... Karmaus) and R01 AI061471 (PI: Susan Ewart). The 10-year follow-up of this study was funded by National Asthma Campaign, UK (Grant No 364) and the 18-year follow-up by NIH/NHLBI R01 HL082925-01 (PI: S

The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

number R01 AI091905 (PI: Wilfried Karmaus), 1R21AI099367 (PI: Hongmei Zhang), and R01 AI061471 (PI: Susan Ewart). The 10-year follow-up of this study was funded by the National Asthma Campaign, UK (Grant

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

IntroductionInstrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade...

Interactive effect of STAT6 and IL13 gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study

7 Julian M Hopkin 1 Eric M Schauberger 6 Marsha Wills-Karp 5 John W Holloway 4 9 Syed Hasan Arshad 4 8 Hongmei Zhang 3 Wilfried Karmaus 0 0 Division of Epidemiology, Biostatistics, and Environmental

Interplay of Filaggrin Loss-of-Function Variants, Allergic Sensitization, and Eczema in a Longitudinal Study Covering Infancy to 18 Years of Age

Background Immune specific genes as well as genes regulating the formation of skin barrier are major determinants for eczema manifestation. There is a debate as to whether allergic sensitization and filaggrin gene (FLG) variants lead to eczema or FLG variants and eczema increase the risk of allergic sensitization. To investigate the time-order between eczema and allergic...

Offspring of parents with Balkan Endemic Nephropathy have higher C-reactive protein levels suggestive of inflammatory processes: a longitudinal study

Background Despite the characteristic extensive tubulointerstitial fibrosis, Balkan Endemic Nephropathy (BEN) is usually considered a non-inflammatory disease. Methods We examined a marker of inflammation, C-reactive protein (CRP), in the offspring of patients with BEN, a population at risk for BEN, prior to development of established disease to determine if an inflammatory...